Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors present the case of mitral valve prolapse. In a young woman with three-year history of systematically treated epilepsia mitral valve prolapse with a spurious string within left ventricle has been diagnosed echocardiographically in coincidence with the symptoms of haemorrhagic diathesis of von Willebrand type in form of haemoptysis and or/massive haemorrhages in mouth occasionally being preceded by heart rhythm disturbances. No local changes have been observed in otorhinolaryngologic examination, bronchoscopy and gastroscopy. Possible mutual dependence of 3 above stated abnormalities is being discussed. It is not excluded, that mitral prolapse may constitute the primary entity and epilepsia is of secondary character as a result of cerebral ischaemic incidents or of cerebral embolism. It is also a matter of discussion to what extent abrupt haemodynamic disturbances connected with critical fall of systemic blood pressure due to mitral prolapse may influence the haemorrhagic episodes.
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PMID:[Coexistence of von Willebrand's disease with mitral valve prolapse]. 130 May 78

A left-sided diaphragmatic defect in the centrum tendineum of a 27-year-old female patient, who complained about dyspnea and hemoptysis, will be reported concerning symptoms, diagnostic procedure and operative therapy. This presumably congenital diaphragmatic defect caused an organ prolapse into the pleural cavity probably enhanced by an increased intraabdominal pressure during pregnancy and delivery. The defect was primarily closed after laparotomy. No plastic surgical reconstruction with autologous or homologous materials was necessary.
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PMID:[Congenital diaphragmatic hernia with symptoms in adulthood]. 777 48

Chest x-ray remains a critical investigation in patients who present with shortness of breath. We report a 60-year-old man who presented with shortness of breath, haemoptysis and respiratory failure, a raised white cell count, and right upper-and mid-zone infiltrates on chest x-ray. He developed progressive multiple organ failure despite aggressive intensive care management with antibiotics, ventilation and inotropes. As his haemodynamic instability continued to worsen, transthoracic, and subsequently transoesophageal, echocardiography revealed posterior mitral valve leaflet prolapse with severe mitral regurgitation. Mitral valve repair and annuloplasty led to eventual complete resolution of symptoms. The changes seen in the right upper and mid zones on initial chest x-ray were due to the mitral regurgitant jet being directed predominantly towards the right superior pulmonary vein. We report this case to highlight a rare but important cause of lobar oedema, and the usefulness of echocardiography in assessment of the patient with complex critical illness.
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PMID:An unusual cause of right upper- and mid-zone infiltrates on chest x-ray. 1776 52

Infection of the central nervous system with Nocardia sp. usually manifests as supratentorial abscesses. Supratentorial and cerebellar abscesses from infection with Nocardia sp. following immunosuppression with long-term corticosteroids for idiopathic thrombocytopenia (ITP) have not been reported. An 83 years-old, human immunodeficiency virus (HIV)-negative, polymorbid male with ITP for which he required corticosteroids since age 53 years developed tiredness, dyspnoea, hemoptysis, abdominal pain, and progressive gait disturbance. Imaging studies of the lung revealed an enhancing tumour in the right upper lobe with central and peripheral necrosis, multiple irregularly contoured hyperdensities over both lungs, and right-sided pleural effusions. Sputum culture grew Nocardia sp. Neurological diagnostic work-up revealed dysarthria, dysphagia, ptosis, hypoacusis, tremor, dysdiadochokinesia, proximal weakness of the lower limbs, diffuse wasting, and stocking-type sensory disturbances. The neurological deficits were attributed to an abscess in the upper cerebellar vermis, myopathy from corticosteroids, and polyneuropathy. Meropenem for 37 days and trimethoprime-sulfamethoxazole for 3 months resulted in a reduction of the pulmonary, but not the cerebral lesions. Therefore, sultamicillin was begun, but without success. Long-term therapy with corticosteroids for ITP may induce not only steroid myopathy but also immune-incompetence with the development of pulmonary and cerebral nocardiosis. Cerebral nocardiosis may not sufficiently respond to long-term antibiotic therapy why switching to alternative antibiotics or surgery may be necessary.
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PMID:Cerebellar nocardiosis and myopathy from long-term corticosteroids for idiopathic thrombocytopenia. 2004 27

A 19-year-old man presented with sudden onset of right eye ptosis, diplopia and giddiness. He had no previous medical illnesses with negative history of exertional dyspnoea, epistaxis, haemoptysis, palpitations, chest pain and chronic cough. Examination revealed central cyanosis, digital clubbing, polycythaemia, partial ptosis of right eye, diplopia on right gaze and dilated right pupil. Examination of the chest revealed pectus excavatum but no cardiac murmurs were heard. Investigations revealed a solitary right pulmonary arteriovenous malformation with two feeder vessels which were successfully embolized surgically.
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PMID:The blue man who presented with a stroke. 2560 17

A 33 year old male patient has found in the oral cavity tumor with nausea and vomiting after 20 days ago. The patients feel pharyngeal foreign body sensation, occasional sense of suffocation, the oropharyngeal tumor disappeared and foreign body sensation disappeared after swallowing. The patients without angina, no hemoptysis, no hoarseness, no acid reflux symptoms and weight loss phenomenon. The gastroscope showed giant tumor, esophagus smooth surface, visible local gray blue blood vessels, from the entrance of esophagus has been extended to the esophagus from the upper incisors 25 cm. The huge polypoid matters originate from the entrance of esophagus, esophageal mucosa prolapse entrance left wall like folds, about 13 cm long. Inspecting the electronic laryngoscope: esophageal entrance polypoid tissue after vomiting, spit to form red giant oropharyngeal neoplasm. After the tumor swallowing into the esophagus, checking the laryngeal vestibule, bilateral aryepiglottic fold and pyriform sinus are normal. The pathological sections were diagnosed as fibrous hemangioma by HE staining.
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PMID:[Fibrous hemangioma of esophagus portal: a case report]. 2977 Oct 50