Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 702 examinations were conducted on young (16 to 31 months) beef bulls of 3 breeds and 3 breed crosses (Brahman cross--100; Africander cross--93; Shorthorn cross--109; Brahman--81; Africander--89, and Hereford--230). A high occurrence of both increased size (overall 11.7%) and consistency (overall 40.2%) of seminal vesicles was observed. The Hereford breed had most enlarged (19.1%, P less than .01) and firm (20.9%, P less than .01) seminal vesicles. The significance of these findings is discussed. Testicular hypoplasia was diagnosed in 2.7% of examinations. The Brahman breed had most testicular hypoplasia (8.6%, P less than .01). The implications of this finding are discussed and the need is stressed for a wider investigation of gonad development in the Brahman breed in Australia. Other findings included: small seminal vesicles in 1.6% of examinations (Brahman breed highest with 8.6%, P less than .001), enlarged ampullae, 1.9%, 'soft' testicles, 3.4% and small testicles, 7.5%. Abnormal carriage of the testicles was detected in 0.3% of examinations. Ulceration of the prepuce was observed in 6.8% of examinations. The highest occurrences were in the SH (13.8%, P less than .01) and Africander (13.5%, P less than .05) breed groups. Varying degrees of preputial eversion or prolapse were seen in 0.7% of examinations with the Bx breed group having highest representation (3.0%, P less than .05).
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PMID:Breed differences in abnormalities of the reproductive organs of young beef bulls. 74 41

Groups of 25 male Sprague-Dawley rats were treated by gastric intubation with either vehicle control (modified methylcellulose) or a suspension of losulazine at 4, 8, 16, or 32 mg/kg/day for 1 yr. Ten rats/group were killed after 6 months of treatment. Reversibility of drug-induced changes was evaluated in 8 rats/group treated for 6 months and held without treatment for 5 months. Daily clinical signs and weekly body weight changes were monitored. Seminal vesicle/coagulating glands were weighed in rats treated for 6 months. Gross and microscopic evaluation of the accessory sex glands (ampullary glands, prostate, seminal vesicles and coagulating glands) was conducted in all rats killed at 6 months, after the recovery period, and in rats that survived through the one-yr treatment period. Ptosis, somnolence, and fecal softening were detected in all groups treated with losulazine. There was a nonreversible body weight gain retardation in groups treated with 8 to 32 mg/kg/day of losulazine for 6 months or 1 yr. Absolute and relative weights of the seminal vesicle/coagulating glands of treated rats were not significantly different from those of control rats. The ventral prostate in a few rats in all treated groups had yellow to tan granular foci. Treatment, but not dose-related sperm granulomas or glandular impaction with inspissated secretion (formation of corpora amylacia) in the ampullary glands, enhanced cellular exudation into the acini of the ventral prostate, and impaction of the seminal vesicles with altered granular to globular secretion were found in rats treated with losulazine.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Pathologic changes in the accessory sex glands of rats treated with a sympatholytic hypotensive agent (losulazine). 281 27