Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033377 (prolapse)
11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Achieving a stable repair of mitral valve prolapse can be difficult in complex pathologies, and a 5% to 20% late reoperation rate exists with leaflet resection and reconstruction. During an 8-year period, prolapse was managed uniformly with "adjustable" Gortex (W. L. Gore & Associates Inc, Flagstaff, AZ) artificial chordal replacement and Carpentier ring annuloplasty (Edwards Lifesciences LLC, Irvine, CA), without leaflet resection. Artificial chords were placed initially in the papillary muscles, and then after ring annuloplasty they were adjusted to optimize length to the prolapsing segment(s). Of 52 patients with prolapse, 100% were repaired successfully with artificial chords. Operative mortality was 1.9%, and 4, 6, and 8-year survivals were 87%, 81%, and 71%, respectively. Only 1 of 52 patients (1.9%) experienced late failure, and this patient was re-repaired with artificial chords. Thus, "adjustable" artificial chordal replacement facilitates uniform repair of mitral valve prolapse with a low late failure rate.
...
PMID:"Adjustable" artificial chordal replacement for repair of mitral valve prolapse. 1656 19

A 43-year-old male patient undergoing mitral valve repair because of severe mitral regurgitation as a result of P2 prolapse was treated with insertion of neochords and a 36 Carpentier-Edwards physio-ring. After weaning from cardiopulmonary bypass, S-T elevation in leads II, III, and aVF occurred. On transesophageal echocardiography an occlusion or distortion of the circumflex artery by ring sutures was suggested, because coronary flow was no longer detected by color Doppler. Despite stable hemodynamics an angiogram was performed, which confirmed the diagnosis of stenosis of the circumflex artery. During reoperation 4 sutures placed at the P1 segment of the mitral valve annuloplasty were corrected. Transesophageal echocardiography could detect a good flow of the circumflex artery and the electrocardiographic changes disappeared.
...
PMID:Ligation or distortion of the right circumflex artery during minimal invasive mitral valve repair detected by transesophageal echocardiography. 1790 69

Ischemic iatrogenic lesions can complicate surgical procedures on the mitral valve. One of the causative mechanisms is direct injury to or distortion of the circumflex coronary artery. The risk of damaging the circumflex coronary artery depends mainly upon the proximity of that vessel to the posterior segment of the mitral annulus, and this varies from patient to patient. Herein, we report a case of iatrogenic circumflex coronary artery lesion after mitral annuloplasty, and we review the literature on the subject, in order to highlight a possible relationship between iatrogenic circumflex lesions and coronary dominance. In a 60-year-old man who had severe mitral regurgitation due to prolapse of both leaflets, preoperative coronary angiography showed irregularities only along the left anterior descending coronary artery and a coronary network of right dominance. The patient underwent mitral annuloplasty (32-mm Carpentier-Edwards ring) by means of minimally invasive right thoracotomy through the right 4th intercostal space (HeartPort). When the procedure was over, and before the patient was taken to intensive care, ventricular fibrillation developed; the administration of direct-current shock (200 joules) resulted in a resumption of sinus rhythm. Repeat transesophageal echocardiography showed posterolateral dyskinesis of the left ventricle and ST-segment elevation suggestive of acute lateral myocardial infarction. Emergency cardiac catheterization revealed a subocclusion of the distal circumflex coronary artery. Dual percutaneous angioplasty and stenting (Taxus, 2.5 x 24 mm) was performed with optimal result. At the 1-year follow-up, the patient showed good results of the mitral annuloplasty.
...
PMID:Iatrogenic circumflex coronary lesion in mitral valve surgery: case report and review of the literature. 1861 92

Perineal hernias are very rare and mostly reported in adults, with only 7 cases reported in children. We report a female fetus, terminated at 18 weeks of gestation due to trisomy 18. In addition to multiple typical findings of trisomy 18, this fetus had perineal hernia with defect of the perineal skin and prolapse of multiple bowel loops. To our knowledge there are no reported cases of perineal hernia presenting antenatally nor are there reported cases of perineal hernia associated with trisomy 18.
...
PMID:Congenital perineal hernia in a fetus with trisomy 18. 1924 Dec 40

Congenital aneurysm of the body of the left atrium causing severe mitral incompetence is extremely rare. The cause of mitral incompetence has been attributed to a distortion of the mitral annulus by the aneurysm, or to coexisting pathology in the mitral valve apparatus. Surgical techniques to treat this condition include excision of the aneurysm along with mitral valve repair or replacement. Herein is described the case of a 30-year-old man with large aneurysm of the left atrial body and severe mitral regurgitation (MR) treated by endoatrial patch plasty. The mitral incompetence was due to prolapse of the posterior mitral annulus into the neck of the aneurysm. Under cardiopulmonary bypass, the neck of the aneurysm was closed using a Dacron patch. Endoaneurysmorrhaphy with a Dacron patch effectively restored the mitral competence and simultaneously excluded the aneurysm from the left atrium. To further strengthen the posterior mitral annulus, a mitral annuloplasty was added using a rigid Carpentier-Edwards ring. The patient was anticoagulated with warfarin for six weeks after surgery. Transthoracic echocardiography performed at a six-month follow up confirmed the absence of any residual aneurysm or MR. To the authors' knowledge, this is the first case of left atrial aneurysm with severe MR to be treated in this way.
...
PMID:Severe mitral regurgitation due to left atrial aneurysm corrected by endoatrial patch plasty. 1945 88

A 54-year-old man, scheduled for a clavicle fracture repair, appeared asymptomatic with 120 beats x min(-1) tachycardia and ECG abnormalities in preoperative anesthetic interview. He was not suffering from pain derived from clavicle fracture despite tachycardia. He was consulted with a cardiac physician. Downward displacement of tricuspid valve was detected by echocardiography and he was diagnosed Ebstein's anomaly. Right-left shunt did not exist, tricuspid regurgitation was grade I, and LV function was within normal ranges. Hence our anesthetic goal was to avoid arrhythmia, anesthesia was induced and maintained with propofol and remifentanil, and arterial pressure-based cardiac output monitor (FloTrac, Edwards Lifesciences, Irvine, CA, USA) was applied to measure cardiac output. Consequently, heart rate was controlled adequately, and intraoperative anesthetic course was uneventful. The number of adult patients with congenital heart disease has increased because techniques of echocardiography and surgical procedure have been improved. Anesthesiologists should be more aware of congenital heart disease in adults.
...
PMID:[Ebstein's anomaly in an adult patient detected by sinus tachycardia by preoperative anesthetic interview]. 2056 Mar 89

Robotic mitral valve repair (RMVR) is less invasive and potentially more precise. However, RMVR lengthens both cardiopulmonary bypass and arrested heart times. In our initial experience, only posterior leaflet repair and/or annuloplasty were performed. With increasing experience, we have performed more complex bileaflet RMVR. A 50-year-old man presented with severe mitral regurgitation. Transesophageal echocardiography (TEE) demonstrated a complex bileaflet prolapse and preserved left ventricular function. Through a 4 cm working port and with the da Vinci Robotic Surgical System (Intuitive Surgical, Sunnyvale, CA) RMVR was performed. Details of the technique and patient's hospital course are described. The repair comprised closure of clefts between A3 and P3, quadrangular resection of P2, transfer of multiple chords from P2 to A2/A3 and a #38 Cosgrove-Edwards (Edwards Lifesciences, Irvine, CA) band annuloplasty. Nitinol U-Clips (Medtronic, Minneapolis, MN) were used to complete the annuloplasty. Postoperative TEE showed no mitral regurgitation. The patient was discharged on the third postoperative day. Cardiopulmonary bypass and arrested heart times were 3 hours and 29 minutes and 2 hours and 59 minutes, respectively. Complex bileaflet repair of mitral valve with Barlow's disease can be successfully performed with the da Vinci Robotic Surgical System. Long-term follow-up is needed to assess the durability of repair.
...
PMID:Complex Bileaflet Mitral Valve Repair (Barlow's) Using the da Vinci Robotic Surgical System. 2243 60

One-third of the patients with severe symptomatic aortic valve stenosis (sAS) present with hemodynamic relevant mitral valve insufficiency (rMI). In patients who undergo conventional surgery, the rMI never would be left untreated; however, in cases of transcatheter aortic valve implantation (TAVI), the impact of rMI is often overlooked and left untreated. The combination of transapical TAVI (TA-TAVI) and NeoChord implantation represents a novel, promising therapeutic option for high-risk-surgery patients with sAS and rMI due to a prolapsed or flailed leaflet. This case report describes 2 patients (1 male, 1 female; mean age 82 years) who underwent TA-TAVI and concomitant NeoChord implantation at our institute. Both presented with sAS and rMI due to a prolapse of the P2 segment of the mitral valve. At first, the TA-TAVI was implanted under angio-guidance, followed by three-dimensional echo-guided implantation of the NeoChords, through the same approach, which was slightly posterior and lateral to the apex. TA-TAVI using an Edwards Sapien 3 (26 mm, n = 1 and 29 mm, n = 1) and NeoChord implantation (2 in the first and 3 in the second patient) was successful in both cases. Post-intervention discharge echo indicated no paravalvular or central insufficiency after the procedure and only a trace of mitral valve insufficiency. TA-TAVI and concomitant NeoChord implantation is a feasible and promising treatment option for high-risk patients with rMI. Despite its technical demands, in experienced hands, it is a safe procedure for those not well suited for surgical intervention.
...
PMID:Concomitant Transapical Transcatheter Aortic Valve Implantation and Transapical Mitral Valve Repair With NeoChord Implantation. 3152 23


<< Previous 1 2