Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients of young age predominated in the group of 113 patients (69 males, 44 females) with orbital rhinogenic inflammation observed by the authors. 57.5% of the cases arose due to acute sinusitis, 42.5%-due to exacerbation of chronic sinusitis. The inflammation focus developed more frequently in the frontal sinuses and ethmoid labyrinth. Periostitis was diagnosed in 17 patients, subperiosteal orbital abscess in 9 patients. Inflammation of the orbital soft tissues presented as eyelid and orbital fat edema in 66 patients, as retrobulbar abscess in 11 and phlegmon in 10 patients. The treatment policy combined intensive antiinflammatory therapy and surgery if indicated. The treatment aimed at both elimination of the inflammatory focus in the sinus and drainage of the inflammatory focus in the sinus and drainage of the secondary suppuration focus in the orbit. A 100% cure was achieved, though residual phenomena such as limited movements of the eyeball, partial ptosis, reduced visual acuity, loss of vision (3, 3, 2 and 1 patients, respectively) remained.
 ...
PMID:[Rhinogenous inflammatory diseases of the orbit]. 909 87

Orbital emphysema is a rare condition in the absence of trauma or sinus disease. We report two cases of orbital emphysema caused by sneezing. The patients presented with sudden unilateral eyelid swelling after sneezing. Otorhinolaryngologic and ophthalmic examinations were accompanied by computed tomography (CT). Patient examination disclosed crepitant eyelid swelling, ptosis, and mild unilateral exophthalmos. CT demonstrated areas of emphysema in the orbit. One patient had history of past trauma. The other patient had a history of nasal surgery and concurrent chronic sinusitis. Sneezing may cause orbital emphysema in patients with a history of old periorbital trauma or surgery.
 ...
PMID:Orbital emphysema after sneezing. 1605 49

A 43-year-old man was admitted to our hospital because of diplopia, ptosis, and dysphagia that had begun three years previously. He was diagnosed with myasthenia gravis (MG) and invasive thymoma and treated with corticosteroid, thymectomy, and radiation therapy. Ten years after the thymectomy, computed tomography (CT) showed metastasis of the thymoma in the left lower lobe of the lung. Two years after this recurrence, when the patient was 55, respiratory symptoms such as wheezing, persistent cough, and dyspnea appeared. Chronic sinusitis, diffuse centrilobular opacities on CT, and positivity for HLA-B54 led to a diagnosis of diffuse panbronchiolitis (DPB). Despite treatment with clarithromycin, the respiratory symptoms worsened. The patient developed alopecia and body hair loss at the age of 56 followed by dysgeusia, cholangitis, and myositis with positivity for anti-Kv1.4 antibodies. Although treatment with an increased dose of corticosteroid improved hair loss, dysgeusia, cholangitis, and myositis, he died of progression of DPB and serious respiratory infection at the age of 58. In this case, various autoimmune disorders occurred together with MG as complications of thymoma. Although alopecia, dysgeusia, and myositis are already known as complications of MG associated with thymoma, cholangitis is not well-recognized since there have been few reports suggesting a causal relationship between cholangitis and thymoma. Furthermore, DPB caused by immunodeficiency and respiratory tract hypersensitivity associated with thymoma and HLA-B54, respectively, is the distinctive feature of our case. Neurologists should be aware that various organs can be damaged directly and indirectly by abnormal T cells from thymoma in patients with MG.
...
PMID:[A case of myasthenia gravis with invasive thymoma associated with diffuse panbronchiolitis, alopecia, dysgeusia, cholangitis and myositis]. 2528 23