Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary deep venous insufficiency (PDVI) represents an important cause of chronic venous insufficiency (CVI). The clinical picture is generally related to a congenital weakness of the vein wall at the level of the valvular ring which may dilate its diameter with consequent lengthening and prolapse of the valvular cusps. However, in an initial stage of PDVI the leaflets are normally formed and may undergo restorative surgery. In this condition an external banding valvuloplasty (EBV) with a Dacron sleeve around the incompetent valve may restore the competence. The authors report 54 cases of superficial femoral vein EBV performed over a period of 1986 to 1991. The patients were affected by signs of CVI and/or relapsing, complicated or atypical varices in which descending venography showed a grade II, III or IV primary deep reflux. In a mean follow-up of 38 months (4 to 63 months) deep reflux had disappeared in 41 patients (76%), had significantly decreased in 8 (14.8%) and was completely unmodified in 5 (9.2%). According to the experience of other authors, these results suggest the therapeutic validity of EBV in the initial stage of PDVI.
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PMID:External banding valvuloplasty of the superficial femoral vein in the treatment of primary deep valvular incompetence. 782 97

Undifferentiated connective tissue dysplasia (UDCTD) is a common type of congenital mesenchymal defect. Among the visceral manifestations of UDCTD, cardiac anomalies have been studied in detail while the nature, extent, and clinical significance of changes in other viscera are much less known. The review summaries data on currently accepted extracardiac manifestations of UDCTD, such as venous insufficiency, tracheobronchial dyskinesia, nephroptosis, genital prolapse, gastrointestinal disorders, hemostatic pathology.
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PMID:[Extracardiac manifestations of undifferentiated connective tissue dysplasia]. 1466 63

Lymphedema-distichiasis syndrome (LD, OMIM 153400) is an autosomal dominant disorder with variable expression. It is caused by mutations in the FOXC2-gene, which codes for a forkhead transcription factor involved in the development of the lymphatic and vascular system. LD is characterized by late childhood or pubertal onset lymphedema of the limbs and distichiasis (double row of eyelashes). While the latter is the most common expression of LD, venous insufficiency occurs in half of the patients. Other associations have been reported, including congenital heart disease, ptosis, cleft lip/palate and spinal extradural cysts. Here we describe a family with classical lymphedema-distichiasis syndrome caused by a duplication in the FOXC2-gene.
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PMID:Lymphedema-distichiasis syndrome: a distinct type of primary lymphedema caused by mutations in the FOXC2 gene. 1898 89