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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six hundred and twenty-one hysterectomies were performed at National Women's Hospital, Auckland, during 1975. Abnormal vaginal bleeding was the clinical indication in 50.72% of the cases. Fibroids, pelvic mass, prolapse, stress incontinence and cervical neoplasia were the indication for 45.88% of the cases. Total hysterectomy was performed in 618 (99.5%) patients whilst sub-total hysterectomy was done in only three cases. Histopathological studies revealed that 567 (91.30%) specimens were pathological and there was multiple pathology in 55.87% of the specimens. Leiomyomas were present in 278 cases (44.76%); microleiomyomatosis in 178 specimens (22.66%); endometrial hyperplasia in 139 specimens (22.33%) adenomyosis in 87 cases (14.00%); malignant diseases in 76 cases (12.23%); and endometriosis in 40 specimens (6.44%). There were no histological abnormalities in 54 specimens, 8.69% of this series.
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PMID:The pathology of hysterectomy specimens. 28 33

Based on the data of a questionnaire this study was designed to follow the obstetrical and gynecological history of 269 women who were delivered at our hospital by Caesarean section during 1960-1969. The Caesarean section group was compared with a control group of 229 women who were delivered spontaneously during the same period. Patients with cesarean sections had less children and more often they had been afraid of further deliveries. In patients with vaginal deliveries there was a significant higher incidence of descensus and prolapse uteri and more often a therapy because of premalignant or malignant diseases of the cervix had to be performed. However, there was no significant difference in the frequency of hysterectomies in both groups. The main indication for hysterectomy in the vaginal delivery group was prolapse and descensus, and in the Caesarean section group fibromyoma of the uterus. Except one case of uterine rupture the rate of complications in subsequent pregnancies was similar for both groups. Compared to the control group a higher rate of maternal morbidity due to Caesarean section could not be proved.
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PMID:[Late morbidity following cesarean section--a neglected factor]. 335 Mar 22

Between 1982 and 1984 330 women in postmenopause for at least one year were admitted to the First Clinic of Obstetrics and Gynecology, Catania University Medical School, Catania, Italy, with a frequency of 10.04% of gynecological admissions. The most frequent pathologies were metrorrhagia (32.72%; 108 cases) from an atrophic endometrium or glandular hyperplasia of the endometrium, vaginoperineal lacerations with cystorectocoele with or without urinary incontinence (10.90%; 36 cases), cancer (11.21%; 37 cases) and ovarian cystoma (11.21%; 37 cases), uterine prolapse (9.30%; 31 cases), and endometrial polyps (9.09%; 30 cases). Uterine fibromyoma (3.93%; 13 cases) and carcinoma of the portio (3.93%; 13 cases) were among the rare pathologies. Uterine pathologies were the most prevalent (68.78%; 227 cases), followed by ovarian (15.15%; 50 cases), pathology of involving the pelvic and perineal containment (10.90%; 36 cases), vulvar pathology (2.72%; 6 cases), and vaginal pathology (1.51%; 5 cases). Malignant neoplastic pathology was reported in 25.45% of cases (84 cases) consisting only of uterine cancer (47.61%; 40 cases) and ovarian cancer (45.23%; 38 cases). In comparison with the study performed by Cetroni in 1952 one notes a net reduction in the frequency of uterine prolapse (by about three times), and a smaller reduction in cancer of the uterine cervix with a slight increase in cervical polyps, endometrial cancer, and above all in metrorrhagia from atrophic endometrium or glandular hyperplasia of the endometrium.
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PMID:Current aspects of gynecological pathology in postmenopause. 340 88

Trends in hospitalizations for selected gynecologic diagnoses per 100,000 women/year associated with hysterectomy were analyzed using the Finnish hospital discharge register data, including each inpatient episode in all Finnish hospitals, from 1971 to 1986. The diagnoses selected were uterine leiomyoma, genital prolapse, the group 'other disorders of the uterus' including endometriosis, and bleeding disorders. These were the most common indications for hysterectomy in Finland from 1987 to 1989, when national data on surgical procedures were included in the hospital discharge register. Trends in the incidence of hospitalizations for malignant neoplasms were also analyzed, although < 10% of hysterectomies are due to gynecological malignancies. Hospitalizations for leiomyoma, endometriosis and bleeding disorders have statistically increased, significantly, among women aged 45 years or more between 1971 and 1986, whereas hospitalizations for prolapse and malignant neoplasms did not show a significant change. Probable incidence of hysterectomy before 1986 was estimated on the basis of the annual incidence of hospitalization for leiomyoma, and hysterectomy for leiomyomas was estimated from the hospital discharge register data of 1988. According to hospital discharge data in 1988, 90% of the hospitalized women with leiomyoma underwent hysterectomy and half of the hysterectomies were performed for leiomyoma. The estimated incidence of hysterectomy increased from 311/100,000 women to approximately 400/100,000 from 1971 to 1986 (slope = 6.5 hysterectomies/100,000/year; 95% C.I. for slope (4.8:8.2)). As the epidemiology of most of the underlying disorders for indications leading to hysterectomy is poorly known, epidemiological studies should consider the determinants of the occurrence of indications independently whether hysterectomy has been performed or not.
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PMID:Five gynecologic diagnoses associated with hysterectomy--trends in incidence of hospitalizations in Finland, 1971-1986. 796 47

We here report a rare case of giant cell arteritis (GCA) of the myometrium found incidentally in a 68-year-old Caucasian woman presenting with uterovaginal prolapse and a known past history of temporal arteritis/polymyalgia rheumatica. Histology revealed a segmental arteritis of small, medium and some quite large myometrial arteries with extensive destruction of both internal and external elastic laminae. Multinucleate giant cells, lymphocytes and histiocytes were most prominent in the inflammatory infiltrate. The findings in this case are compared with previous reports. In a review of the literature it was found that almost one third of cases presented with generalised symptoms such as fever, anemia, fatigue and weight loss. The symptoms were not immediately recognised as temporal arteritis or polymyalgia rheumatica. On routine physical examination or radiological investigation, benign gynecological pathology such as a simple ovarian cyst or uterine leiomyoma were found. The subsequent unexpected discovery of GCA on histological examination was the critical event in alerting clinicians to the diagnosis of temporal arteritis/polymyalgia rheumatica. Without exception steroid therapy was successful in achieving relief of generalised symptoms.
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PMID:Giant cell arteritis of the uterus: case report and review. 921 48

A prospective cross-sectional study involving 14 government hospitals was undertaken for a period of 6 months in Malaysia to study the patterns of hysterectomy for gynaecological indications. A total of 707 patients were enrolled in the study consisting of 612 abdominal hysterectomies and 95 vaginal hysterectomies. Fibroids (47.6%) and uterovaginal prolapse (13.4%) formed the main indications for surgery. The initial preoperative diagnosis was accurate in 82.8% of cases. A different pathology from that initially suspected was noted in 118 cases. The overall complication rate was 7.9% but vaginal hysterectomies carried a statistically higher complication rate compared to abdominal hysterectomies. Urinary tract infection was significant in vaginal hysterectomies. Blood transfusion was required in 25.0% of abdominal and 6.3% of vaginal hysterectomies. There were no laparoscopic hysterectomies or mortality in this series.
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PMID:A survey of hysterectomy patterns in Malaysia. 1097 22

Pagetoid dyskeratosis, is considered a reactive process in which a small part of the normal population of keratinocytes is induced to proliferate. The lesion is characterized by pale cells resembling those of Paget's disease within the epidermis. These cells have been seen as an incidental finding in a variety of benign papules most commonly located in intertriginous areas. Among the inductors of the lesion, friction is suspected. To the best of our knowledge, these pale cells have not been reported in the cervix. We describe the location of the lesion in the ectocervix and the incidence of this lesion in a group of 100 unselected patients surgically treated for uterine prolapse. Another group of 100 unselected patients treated for uterine leiomyoma was used as a control. Pagetoid dyskeratosis was found in 37 cases (37%) of uterine prolapse and in five cases (5%) of uterine leiomyomas. The lesion is more common in uterine prolapse (p <0.001) and is not significantly associated with cornification of the epithelium (p = 0.72343). The cells of pagetoid dyskeratosis show an immunohistochemical profile different from the surrounding squamous cells characterized by premature keratinization. Pagetoid dyskeratosis cells have shown positivity for high molecular weight cytokeratin and negative reaction for low molecular weight cytokeratin, epithelial membrane antigen, carcinoembryonic antigen, and human papilloma virus. Pagetoid dyskeratosis cells must be distinguished from artefactual clear cells, glycogen-rich cells, koilocytes, extramammary Paget's disease cells, and pagetoid spread of carcinoma cells to the cervix. In cases in which pagetoid dyskeratosis shows a florid expression, there is a hazard of overdiagnosis. The pathologist should be aware of the histologic features of pagetoid dyskeratosis in the ectocervix to avoid misdiagnosis and unnecessary treatment. Routine histologic study is usually sufficient to identify the lesion.
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PMID:Pagetoid dyskeratosis of the cervix: an incidental histologic finding in uterine prolapse. 1107 53

We conducted a retrospective study of all hysterectomies performed in our setting over a two year period (1995-1996). The objective was double: define the indications and precise the outcome. A total of 141 cases were recorded. The main characteristics of the patients were the following: a mean age of 38 years, mean gravidity and parity of 5 and an average number of living children of 3. Hysterectomy was performed by the abdominal route in 86.52% of the cases. The main indications were: uterine rupture (39.71%), uterine myoma (25.53%), genital prolapse (19.89%) and cervix cancer (7.09%). Adnexectomy was associated in 51 cases and it was bilateral in 22 cases. The following complications occurred: 5 deaths, 8 wound abcess, 2 bladder injury, 1 ureter injury and 1 case of post-operative hemorragea.
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PMID:[Hysterectomies in tropical zones: experience of one African maternal health service. 141 cases in Burkina Faso]. 1133 44

To review retrospectively hysterectomy specimens sent to the histopathological department of the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria in order to document the histopathological findings and relate these with the age of patients. The records of patients with hysterectomy specimens sent to the histopathological laboratory within a period of 10 years were studied. Some of the histological slides were reviewed. The diagnosis of uterovaginal prolapse was based on clinical as well as pathological findings. Three hundred and thirty hysterectomy specimens seen over the study period of 10 years were studied. Women aged 40-49 years accounted for the highest number of cases, Hysterectomy was most often performed for leiomyoma (48%). followed by uterovaginal prolapse (17%). In women over the age of 70 years hysterectomy was most often performed for uterovaginal prolapse. Complication of pregnancy still accounted for a high percentage of hysterectomy (11%) Most were ante-partum and post partum haemorrhages as well as septic abortion in young women Ten of the specimens were normal both grossly and microscopically. Six of these were removed for suspected leiomyoma. The peak age incidence for women with leiomyoma who had hysterectomy corresponds with the overall peak age for women who had Hysterectomy. Leiomyoma was the commonest finding in hysterectomy specimens. However, clinicians should ensure that the condition is accurately diagnosed in all cases to avoid removal of a normal uterus.
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PMID:Hysterectomies in Nigerians: histopathological analysis of cases seen in Ile-Ife. 1148 82

A vaginal leiomyoma with heterologous paragangliomatous elements is reported. The patient was a 62-year-old woman who presented with uterovaginal prolapse and an asymptomatic vaginal mass that had been present for many years. Histology of the excised mass showed a leiomyoma in a submucosal location, with irregularly shaped islands of chief cells scattered throughout the lesion. These cells were arranged in nests and were surrounded by S100 protein-positive sustentacular cells. The chief cells showed immunoreactivity with chromogranin, synaptophysin, and neuron-specific enolase. Although various heterologous elements are commonly encountered within uterine leiomyomata, such elements have not been described within vaginal leiomyomata. Furthermore, the occurrence of paragangliomatous tissue within leiomyomata has not been reported to date. Int J Surg Pathol 8(4):359-365, 2000
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PMID:Vaginal Leiomyoma with Heterologous Paragangliomatous Elements. 1149 18


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