Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

68 cases with 76 left ventriculographies, including rheumatic mitral valvular disease, congestive and hypertrophic types of cardiomyopathy, endocardial cushion defect, atrial and ventricular septal defects, coronary heart disease and mitral valve prolapse were analyzed with respect to the morphological and functional changes of the mitral valve and its appendages. Dynamic study with cineradiographic technic was the chief method used in this investigation. Except for ventricular septal defect, all the above-mentioned disease entities showed one or several of the changes of the mitral valvular apparatus including stenosis, insufficiency, displacement, cleft, deformity, prolapse and functional disorder. Regurgitation associated with mitral insufficiency exhibiting specific manifestations in different conditions was analyzed and its method of grading discussed. Mitral valve prolapse with its suggested method grading and functional disorder of the mitral valve were also discussed in detail.
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PMID:[Angiographic diagnosis of lesions of the mitral valve and its appendages]. 252 46

I reviewed the literature on surgical cases of the mitral valvular disease and picked out papers which offer beneficial data for informed consent on mitral valvular surgery. Japanese registries of thoracic cardiovascular surgery in current ten-years showed that the cases of mitral valvuloplasty (MVP) have gradually increased and those of mitral valve replacement (MVR) with mechanical valve prostheses have gradually decreased. The current guideline for indication of PTMC, the surgical indication of mitral regurgitation (MR) and the choice of the valve prosthesis are presented. The freedom from structural valve deterioration after MVR with bioprosthesis and valve related complications with mechanical valve prosthesis, derived from major reports, are demonstrated. The freedom from reoperation and recurrence of MR after MVP for posterior, anterior and both leaflets are demonstrated. Recently, the differences between Barlow disease and fibroelastic deficiency in MR have been focused. To assess the prognosis and morbidity after MVP for MR, several papers emphasized that not only the location of the prolapse lesion but the etiologic classification of the degenerative mitral valve disease is also important.
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PMID:[Mitral valvular disease]. 2191 70

Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence indicates that the mitral valve is not a passive structure, but--even in adult life--remains dynamic and accessible for treatment. This concept motivates efforts to reduce the clinical progression of mitral valve disease through early detection and modification of underlying mechanisms. Discoveries of genetic mutations causing mitral valve elongation and prolapse have revealed that growth factor signalling and cell migration pathways are regulated by structural molecules in ways that can be modified to limit progression from developmental defects to valve degeneration with clinical complications. Mitral valve enlargement can determine left ventricular outflow tract obstruction in hypertrophic cardiomyopathy, and might be stimulated by potentially modifiable biological valvular-ventricular interactions. Mitral valve plasticity also allows adaptive growth in response to ventricular remodelling. However, adverse cellular and mechanobiological processes create relative leaflet deficiency in the ischaemic setting, leading to mitral regurgitation with increased heart failure and mortality. Our approach, which bridges clinicians and basic scientists, enables the correlation of observed disease with cellular and molecular mechanisms, leading to the discovery of new opportunities for improving the natural history of mitral valve disease.
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PMID:Mitral valve disease--morphology and mechanisms. 2648 67