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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

More than 40 plant species have been shown to contain substances that are active in biological assays for estrogenic activity. Such substances may be constitutive metabolic products of a plant, or be formed adaptively in response to environmental factors, such as fungal attack (e.g. coumestrol synthesis in alfalfa infected with Pseudopeziza medicagensis); in other instances estrogens may arise from microbial attack on plant material during storage (e.g. zearalenone formation from corn by Fusarium spp.) Phyto-estrogens may reach man through direct consumption of fresh fruit, vegetables and processed plant products (e.g. administration of olive or cornoil can induce vaginal keratinization in post-menopausal women); or---more relevant to this Symposium---by consumption of carcasses and products from animals fed estrogen-containing forage. Important pasture and forage plants shown to contain phyto-oestrogens include Trifolium subterraneum L, notably the cultivars Dwalganup, Mt. Barker, Yarloop and Marrar, T. pratense (red clover), T. fragiferum L. (strawberry clover), T. alexandrinum (berseem clover), Medicago sativa (alfalfa or lucerne) and Soya hispida (soya beans). A beneficial anabolic action of the estrogens contained in these plants has been implied, but not unequivically established. More attention has been paid to their noxious effects on livestock. On affected T. subterraneum pasture, castrated male sheep showed lactation, squamous metaplasia of the bulbo-urethral glands and urethral stenosis; infertility, variously attributed to suppression of gonadotrophin release and ovulation; faulty ovum transport; premature regression of corpora lutea; irreversible cystic hyperplasia of endometrial glands on prolonged exposure; dystocia and prolapse of the uterus. Sporadic incidence of phyto-estrogen induced infertility in cattle has been reported, attended by ovarian cyst formation. Estrogenic activity in forage plants has been reported from Australia, New Zealand, India, Sweden, Great Britain, Germany, Denmark, Holland, Finland, Egypt and Israel. The clover constituents chiefly incriminated for these effects are glycosides of the isoflavone derivatives genistein and its 4'-methyl ether biochanin-A, daidzein and its 4'-methyl ether formononetin, and pratensein; coumestrol and its 3'- and 4'-methyl ethers account for the estrogenic activity of alfalfa. The isoflavone content of subterranean clover may reach 3 percent of its dry weight, and the coumestrol content of lucerne may exceed 100 mug/g. Coumestrol and genistein compete with 17beta-estradiol for binding sites on the uterine cytoplasmic receptor and induce macromolecular synthesis in the uterus, but fail to induce ovum implantation in ovariectomized, gestagen-maintained rats. Uterotrophic activity of coumestrol and genistein given parenterally to sheep is approximately 10(-3) and 10(-5) times that of stilboestrol, respectively. Biological activity of ingested phytoestrogens is modified by ruminal micro-organisms and hepatic metabolism...
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PMID:Occurrence of anabolic agents in plants and their importance. 106 75

Two cases of severe uterine prolapse are reported following laser uterosacral nerve ablation (LUNA). Both patients had a history of vaginal childbirth and subsequent development of secondary infertility and severe dysmenorrhea. It is suggested that this procedure be performed with caution on vaginally parous patients, and that it be reserved for use in patients who have adequate uterine support. Future studies are needed to determine the long-term incidence of uterine procidentia following this procedure.
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PMID:Uterine prolapse after laparoscopic uterosacral transection. A case report. 128 13

Genital prolapse is a disorder of pelvic support and is one of the most frequent disorders encountered in our gynaecological practice. Our social and cultural background predisposes to this condition to occur at an age which is reported to be earlier than any part of the world. Over a period of 4 years, 1986-1989, 17 cases were studied in whom the Sleeve Excision anastomosis operation was carried out, either at the Lokmanya Tilak Municipal General Hospital, Sion, Bombay, India or in some other hospital. All these patients were either admitted in active labour or as cases of abortions or were being treated for infertility. The incidence of full-term normal vaginal delivery in our study was 66.6% and the incidence of Caesarean section was 8.3%. There was 1 case of posterior wall rupture following previous sleeve excision anastomosis operation. The recurrence rate of prolapse in our series was only 7.7%. The Sleeve excision anastomosis operation has given excellent anatomical and obstetric results in our study and future multicentric trials will be necessary to study its effect on subsequent fertility to arrive at any final conclusion.
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PMID:Reproductive performance following sleeve excision anastomosis operation for genital prolapse. 152 Feb 1

Over a period of 4 years from January 1986 to December 1989, 79 cases in whom Shirodkar's abdominal sling operation carried out, were studied. All the patients were admitted either in active labour or as cases of abortions or for the treatment of infertility. The incidence of full term normal vaginal delivery in this study was 69.56% and the incidence of caesarean section was only 2.9%. There was one case of posterior wall rupture following previous Shirodkar's sling operation. The recurrence rate of prolapse was only 8.69%.
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PMID:Reproductive performance following Shirodkar's abdominal sling operation. 158 14

Combined blepharophimosis, ptosis, and epicanthus inversus (BPEI) represent a rare syndrome with autosomal dominant transmission. In affected females it can be associated with infertility. In this case report we could follow the development of primary ovarian failure in a 28-year old woman with BPEI by repeated hormone determinations. Endocrinological and morphological results give good evidence of increasing gonadotropin resistance on the ovarian level.
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PMID:[Ovarian insufficiency in blepharophimosis, ptosis, epicanthus inversus]. 293 4

The relationship between intensity of jogging and various menstrual/reproductive factors in women were investigated. Data were collected by questionnaire from 319 women who participated in a running event that included both a 6.2-mile (10 K) run and a 26.2-mile marathon in northeastern Ohio. Findings reaffirmed the notion that scant menstrual flow, skipped menses, and menstrual irregularity are significantly related to the intensity of jogging; age at menarche, infertility, and uterine prolapse were not. Thirty-two percent of the women felt that jogging decreased their menstrual discomfort, and 44% reported better jogging performance right after or between menstrual periods.
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PMID:Intensity of jogging. Relationship with menstrual/reproductive variables. 656 14

The blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) is rare and autosomal dominant. A family is presented and analyzed together with 38 kindreds with BPES reported in the literature. The results demonstrate the existence of two types of the syndrome: type I with infertility in affected females, and type II which is transmitted by females and males. The two entities are further differentiated by incomplete penetrance only in type II and by differences in the sex ratios of the affected children. Female infertility in type I is a predominant symptom, and the distinction between the two types is of importance for genetic counseling.
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PMID:The blepharophimosis, ptosis, and epicanthus inversus syndrome: delineation of two types. 661 96

A case of mitochondrial myopathy and lactic acidaemia with myoclonic epilepsy, cerebellar ataxia and high-tone hearing loss is presented. There was no ptosis or ophthalmoplegia. Endocrine investigations showed a defect in hypothalamic function which was a likely cause of infertility. The case is compared with previously reported examples of mitochondrial myopathy with myoclonic epilepsy, and contrasted with the Kearns-Sayre syndrome. It is concluded that mitochondrial myopathy, myoclonic epilepsy and ataxia may be distinguishing features of a specific familial disease, which on presentation may mimic the Ramsay-Hung syndrome.
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PMID:Mitochondrial myopathy and lactic acidaemia with myoclonic epilepsy, ataxia and hypothalamic infertility: a variant of Ramsay-Hunt syndrome? 678 98

Estrogens, whether natural or synthetic, have a wide range of clinical uses in the human female. In prepubertal females, estrogens are used in treating gonadal dysgenesis, excessive height, and genital infections. During the reproductive years, estrogens are used in managing 1) menstrual disorders (amenorrhea, menorrhagia, dysmenorrhea); 2) infertility (poor cervical mucus and anovulation); 3) pregnancy (abortion, lactation suppression); 4) dermatological disorders (acne vulgaris, hirsutism); 5) combined estrogen/progestogen usage for contraception; and 6) postcoital contraception. During the climacteric/postmenopausal years, estrogens are used in treating menopausal syndrome and breast cancer as well as various genital problems (infection, atropic vaginitis, genital prolapse). In the human male, estrogens are used in treating prostatic carcinoma and sexual problems. Estrogen therapy should be used with caution, and benefits should be weighed against the hazards. Possible side effects and alternative forms of treatment should be considered.
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PMID:Clinical uses of estrogens. 700 4

Health planners and policymakers in India had virtually no information about reproductive morbidity and its determinants on which to base efforts to improve the reproductive health of women and the acceptance of family planning programs. Thus, a study of self-reported symptoms of reproductive morbidity was undertaken in 1993 in the state of Karnataka as part of a larger research project investigating the pathways through which maternal education affects child survival. Data were gathered through a cross-sectional survey of women living in one subdistrict who were younger than 35 and had at least one child younger than five. Eligibility was limited to 3600 women living in the town and 48 villages with a population over 500. Experienced female interviewers achieved a more than 95% response rate. Disorders associated with the reported symptoms included: menstrual disorders, dyspareunia, hemorrhoids, prolapse, fistula, lower reproductive tract infection (RTI), urinary tract infection, acute pelvic inflammatory disease (PID), infertility, and anemia. Bivariate analysis revealed the significant variations in reports made by women of different socioeconomic, cultural, and demographic backgrounds; a parallel analysis was performed on the proportions seeking treatment for each condition; and logistic regression analysis estimated the net effect of each factor on the likelihood of reporting specific symptoms and the probability of seeking treatment. Independent variables were composed of socioeconomic background, demographic, last live birth and contraceptive usage, and cognitive and behavioral factors. A third of the women reported symptoms of at least one gynecological morbidity, and about half of these sought treatment. A tenth of menstruating women reported menstrual problems, a sixth reported symptoms of lower RTI, 5% reported symptoms indicative of acute PID, and 23% reported symptoms of anemia. Morbidity was influenced by the presence of complications during the pregnancy, delivery, or postpartum period of the last live birth; the location of the last delivery, with less problems reported by those who delivered in a private institution; and whether or not a woman had undergone tubectomy, which increased reporting of all symptom categories except menstrual problems. This points to the urgent need for longterm follow-up studies of sterilized women. Since most women sought private medical treatment, the primary health care facilities should be subject to a radical review and the private sector should undergo systematic evaluation.
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PMID:Self-reported symptoms of gynecological morbidity and their treatment in south India. 748 78


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