Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present nine patients with unilateral congenital ectropion uveae (hyperplasia of the iris pigment border), iris hypoplasia, characteristic gonioscopic findings, and glaucoma. A majority of these patients also demonstrated mild ptosis. In none of these patients were there any associated systemic abnormalities. The apparent ectropion uveae results from spread of the iris pigment epithelium beyond the iris ruff and onto the anterior surface of the iris. In two patients with this abnormality, histopathologic and electron microscopic findings are presented. All patients with congenital ectropion uveae should be carefully examined periodically to detect glaucoma.
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PMID:Primary glaucoma associated with iridotrabecular dysgenesis and ectropion uveae. 402 77

The clinical outcome and final visual acuities of 29 patients with intracapsular lens extraction and keratoplasty to 38 patients having extracapsular cataract extraction and keratoplasty were compared. Grafts remained clear in 89% of the intracapsular group and 82% of the extracapsular group over an average follow-up of 38 months and 21 months, respectively. Ninety-one percent of eyes with intracapsular lens extraction and 70% of eyes in the extracapsular group achieved a final visual acuity of 6/21 (20/70) or better. We found a significantly higher incidence of additional surgery in the extracapsular group and glaucoma in intracapsular combined cases. Late vitreous prolapse with vitreo-endothelial membrane formation and graft decompensation was a discouraging complication in three eyes having intracapsular extractions.
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PMID:A comparison of intracapsular and extracapsular lens extraction combined with keratoplasty. 633 36

Over a period of 4 months, 16 of 24 patients (30 of 46 eyes) with either primary open angle glaucoma (POAG) or suspected glaucoma were treated successfully with a maintenance dose of guanethidine (3%) and adrenaline (0.5%) combined in one eyedrop (GA) once daily. In the previous month the medication was given twice daily and at the end of 4 months the decrease in intraocular pressure (IOP) was 8.9 mm Hg (33%) compared to 9.9 mm Hg (37%) with twice-daily application; three of four eyes responded just as well to single-daily application as to twice daily application of GA. Once-daily treatment with GA was not successful when the average IOP in the absence of treatment was over 32 mm Hg. The advantages of once-daily application were less conjunctival hyperemia, less dilation of the pupils, less ptosis and difficulty reading, plus the advantage that the drops needed only to be applied once a day (patient compliance). The recommended regime for GA therapy in patients with an IOP of less than 32 mm Hg is application of GA twice daily for 1 month followed by a decrease in the dosage to once a day. GA can best be applied in the evening before retiring.
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PMID:Maintenance therapy of glaucoma patients with guanethidine (3%) and adrenaline (0.5%) once daily. 690 83

Extraction only appears indicated in cases of anteriour luxation and phakolytic glaucoma. Visual disturbances due to a dislocated lens should be considered relative indications for removal, since functional improvement cannot be expected as a rule. Expression of the lens through a corneoscleral incision is the method of choice in cases of anterior luxation (Fig. 1) as well as in subluxations without vitreous prolapse (Fig. 2) Open-sky vitrectomy allows for clearing of the route of extraction in cases of subluxation with vitreous in the anterior chamber (Fig. 3). A pars plana approach may be chosen in cases with a soft nucleus (Fig. 4) whereas luxated lenses with a hard nucleus are first aspirated (soft capsule and cortex), then the hard nucleus is luxated into the anterior chamber and finally extracted through a small corneoscleral incision, thus avoiding prolonged perfusion of the anterior chamber necessary for stripper techniques.
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PMID:[Indications and techniques for removal of subluxated lenses (author's transl)]. 696 78

A trial of the efficacy of low-concentration nonmiotic therapy was carried out, the aim being to minimise the side effects produced by 1% adrenaline or pilocarpine. A total of 77 eyes with open-angle glaucoma were studied in both parts of the trial. Thirty-nine eyes had a base-line pressure of over 28 mmHg and 28 eyes a pressure of 30 mmHg or over. In the comparison between Ganda 1.02 and adrenaline 1% (Simplene) the mean lowering of intraocular pressure was 8.6 mmHg with Ganda and 7.69 mmHg with Simplene. In the comparison between Ganda 1.02 and pilocarpine 1% (Sno-Pilo) the mean decrease was 6.34 mmHg with Ganda and 6.13 mmHg with Sno-Pilo. The resulting falls in intraocular pressure were highly significant statistically, but the differences between the effects of the 3 drugs were not significant. No significant side effects were reported with Ganda 1.02, and in particular no ptosis or superficial punctate staining of the cornea was noted.
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PMID:Double-masked cross-over comparison of Ganda 1.02 (guanethidine 1% and adrenaline 0.2% mixture) with gutt. adrenaline 1% (Simplene 1%) and with pilocarpine 1% (Sno-Pilo 1%). 700 78

In seven patients with intracranial meningioma whose presenting signs and symptoms were ophthalmologic the underlying problem was initially misdiagnosed. Three patients had sphenoidal meningiomas with compression of the anterior visual pathways, but the initial diagnoses were acute optic neuritis, chronic optic neuritis and glaucoma. Two other patients had large frontal meningiomas causing in one case unilateral pain and swelling of the upper lid plus ptosis and hypotropia, and in the other case bilateral frontal morning headaches and intermittent blurring of vision in one eye; they were thought to have a frontal lobe osteoma and migraine respectively. A sixth patient had a large parietal meningioma causing unilateral papilledema in an eye with a corneal graft; the papilledema was not initially recognized because of severe astigmatism in that eye. The last patient had an occipital meningioma that had caused a fixed homonymous field defect and many years of "classic migraine".
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PMID:Meningioma and the ophthalmologist: diagnostic pitfalls. 719 8

We compared 15 patients who had undergone Holmium laser sclerostomy ab externo with 15 who had had trabeculectomy. In the short term, laser sclerostomy led to adequate control of intraocular pressure, but in the longer term it compared unfavourably with trabeculectomy in terms of efficacy, complications and reoperation rate. At 1 year follow-up, 8 patients in the laser group had had to undergo a second operation compared with none in the control trabeculectomy group, and 7 were still on glaucoma medication compared with 2 in the control group. Iris prolapse into the internal sclerostomy ostium within 2 months accounted for most failures, and was only partially amenable to Nd:YAG peripheral iridectomy. This common complication seems to be related to anterior chamber depth. There also appears to be a tendency for blockage of the sclerostomy with cellular or fibrinous debris. Recent literature is reviewed and modifying strategies discussed.
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PMID:A comparison of the efficacy of Holmium laser sclerostomy ab externo versus trabeculectomy in the treatment of glaucoma. 782 60

Here we report a new case in which the clinical manifestation were compatible with the phenotype described by Lujan et al. [Am J Med Genet 1984; 17: 311-22] as 'X-linked mental retardation with marfanoid habitus'. Based upon the presence of mild psychomotor retardation, epilepsy and skeletal malformations, a sister can be considered an affected carrier, whereas an older brother showed skeletal abnormalities and juvenile glaucoma. The mother had bilateral palpebral ptosis with minimal mitochondrial abnormalities at muscle biopsy.
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PMID:Mental retardation with marfanoid syndrome: presentation of a family with different phenotypical expression. 825 Jan 52

Since the advent of trabeculectomy with antimetabolite therapy, there have been few changes in the surgical management of glaucoma. This is the first report of a new technique, nonpenetrating trabeculectomy with placement of a collagen drainage device. The procedure facilitates aqueous drainage without entering the human eye. Meticulous surgical dissection of the trabecular meshwork is required with creation of an external filtration tract and subscleral positioning of a collagen device to facilitate aqueous drainage. With this procedure, the surgeon can avoid common complications of glaucoma surgery such as synechias, overfiltration, hypotony, intraocular infection, uveal prolapse, and failed surgical blebs. The procedure and device have been used extensively in Russia.
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PMID:Nonpenetrating trabeculectomy with placement of a collagen drainage device. 855 34

The frequency of genetic eye diseases in a genetic counseling center: In this study the incidence of eye diseases of genetic origin in patients attending our genetic counseling center for a period of almost six years is documented. The frequency of retinitis pigmentosa, congenital cataracts, lens dislocation, microphthalmos, retinoblastoma, congenital glaucoma, congenital ptosis, degenerative myopia, strabismus, optic atrophy, various genetic metabolic diseases have been investigated, and the results are presented. Preventive approaches and prenatal diagnostic possibilities are discussed and the importance of genetic counseling is emphasized.
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PMID:The frequency of genetic eye diseases in a genetic counseling center. 877 20


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