Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Botulinum Toxin A injected into the levator palpebrae superioris produces a flaccid ptosis of the upper lid and provides a safe and effective protection for the cornea to aid healing in indolent ulceration or as prophylaxis when there is fifth or seventh cranial nerve damage. Fifteen patients have received this treatment. Levator paresis, producing ptosis for a mean of 2-3 weeks and recovering in a mean of 8.1 weeks was successfully produced in all patients and complete corneal healing was produced in 80% of patients. The major side effect was weakness of the superior rectus muscle which occurred in 80% of cases and lasted a mean of 6 weeks.
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PMID:Botulinum toxin A induced protective ptosis. 344 41

An analysis of the corneal endothelium of a 23 year old female who had never worn contact lenses but who had unilateral ptosis, showed marked endothelial pleomorphism of the cornea underneath the closed lid. Since corneal hypoxia has been shown to produce corneal endothelial polymegethism in contact lens wearers, and since hypoxic conditions exist under the closed lid, it is reasonable to assume that the polymegethous endothelial changes which occur with aging are a result of chronic corneal exposure to hypoxic conditions under the closed lid during sleep. Corneal hypoxia is apparently not the cause of declining endothelial cell density with age.
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PMID:A theory of corneal endothelial polymegethism and aging. 356 46

Cataract surgery after goniotrepanation has been performed on 75 eyes at the St. Demetrius Hospital Eye Clinic in Thessaloniki , Greece, in recent years. The patients' ages ranged from 46 to 84 years. Intraocular pressure was between 8 and 19 mm Hg in all but 4 eyes which had IOPs of between 22 and 30 mm Hg. In order to leave the fistula untouched, the incision with the Graefe knife was made in the area of the cornea close to the limbus; it was closed with 7 sutures (7-0 silk). Prolapse of the vitreous occurred in 7 cases. It was possible to follow up 52 of the eyes: IOP remained regulated postoperatively with one exception (26 mm Hg); the upper pressure limit was 18 mm Hg.
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PMID:[Cataract operation following goniotrepanation]. 672 35

A lacrimal gland cyst developed as a late complication of Stevens-Johnson syndrome. The mass produced mechanical ptosis and became secondarily infected. Obstruction of lacrimal secretions contributed to a quantitative tear deficiency and epithelial erosions of the cornea. The mass and the keratoconjunctivitis sicca were successfully managed by marsupialization of the cyst wall.
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PMID:Marsupialization of a lacrimal gland cyst. 682 1

Four tarsorrhaphy sutures are placed through the lower eyelid and brow following ptosis surgery in a system designed for patients with external ophthalmoplegia, third nerve paralysis, and myashenia gravis. Three of the sutures connect the lower eyelid to the forehead, and the fourth suture is passed through the lower eyelid and taped to the cheek. The three lid-brow sutures are released during the first two postoperative weeks, one by one, and topical ointment instillations are gradually tapered. The tarsorrhaphy system allows the cornea to adapt gradually to the lagophthalmos that follows ptosis surgery. It also keeps the eyelids partially closed during the first two postoperative weeks in patients with frontalis sling surgery who have marked difficulty lowering their eyebrow and closing their eyelids because of early postoperative forehead edema and pain. The tarsorrhaphy system has prevented serious keratopathy in six patients with ptosis associated with abnormal ocular motility and in one patient with lagophthalmos following trauma. It also allowed the six ptosis patients to have full, rather than partial, correction of their ptosis.
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PMID:Suture tarsorrhaphy system to control keratopathy after ptosis surgery. 699 12

A trial of the efficacy of low-concentration nonmiotic therapy was carried out, the aim being to minimise the side effects produced by 1% adrenaline or pilocarpine. A total of 77 eyes with open-angle glaucoma were studied in both parts of the trial. Thirty-nine eyes had a base-line pressure of over 28 mmHg and 28 eyes a pressure of 30 mmHg or over. In the comparison between Ganda 1.02 and adrenaline 1% (Simplene) the mean lowering of intraocular pressure was 8.6 mmHg with Ganda and 7.69 mmHg with Simplene. In the comparison between Ganda 1.02 and pilocarpine 1% (Sno-Pilo) the mean decrease was 6.34 mmHg with Ganda and 6.13 mmHg with Sno-Pilo. The resulting falls in intraocular pressure were highly significant statistically, but the differences between the effects of the 3 drugs were not significant. No significant side effects were reported with Ganda 1.02, and in particular no ptosis or superficial punctate staining of the cornea was noted.
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PMID:Double-masked cross-over comparison of Ganda 1.02 (guanethidine 1% and adrenaline 0.2% mixture) with gutt. adrenaline 1% (Simplene 1%) and with pilocarpine 1% (Sno-Pilo 1%). 700 78

Corneovitreal attachment represents a major risk to the corneal graft in aphakic eyes. A frequent event after cataract extraction is the hernia-like prolapse of the vitreous into the anterior chamber, sometimes up to the posterior surface of the cornea. Herniation of the vitreous can also occur when keratoplasty and cataract extraction are carried out simultaneously. If the vitreous adherens to the cornea, the young graft becomes opaque. The possibility of vitreous hernia is the most important objection against combined operation. In a few of our cases the cause of the opacification of the graft was corneovitreal contact following the spontaneous internal prolapse of the vitreous. Clear evidence of this was found in the course of reoperations. The opaque grafts obtained proved to be hyalokeratopathies histologically.
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PMID:[Hyalokeratopathy of the corneal graft caused by spontaneous herniation of the vitreous (author's transl)]. 704 6

A 54-year-old man ingested chlorpromazine, 800 mg/day, for ten years and showed conjunctival, corneal, and lenticular changes. Because of a congenital Marcus-Gunn jaw-wink phenomenon in the right eye with subsequent ptosis, he presented an opportunity to compare the anterior segment changes induced by this drug in an eye exposed to sunlight with an eye relatively protected. The changes in the anterior segment were much more marked in the exposed left eye--supporting the hypothesis that chlorpromazine-induced ocular toxicity is a result of drug interaction with sunlight on anterior segment proteins, causing them to denature, opacify, and accumulate in conjunctiva, cornea, and lens.
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PMID:Asymmetric anterior segment changes induced by chlorpromazine. 729 36

Congenital anomalies of the eye occurring in Potter's syndrome have been described, including leucoma cornea, cataract and prolapse of the lens, and expulsive hemorrhage in one eye. The etiological aspects of this association are discussed.
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PMID:Potter's syndrome with ocular anomalies. 739 9

Whereas before the Second World War eyeball injuries involving iris prolapse were treated by excision, it is customary nowadays in almost all cases to attempt restoration of the iris. The authors deal briefly with the various views on when restoration of the iris should be performed, how long after injury it can still be carried out, and the kind of suture and material used. They then describe their operating technique in cases of injury to the cornea and the eyeball in general with iris prolapse, and report their results in 21 cases of cornea injury with iris prolapse and nine cases, also with iris prolapse, where the injury extended to the sclera. Details are given of the time elapsing between injury and operation, the final degree of vision regained, and the aesthetic result. The authors' final conclusion is that in cases of iris prolapse as a result of injury to the cornea and the eyeball in general, an attempt should be made to achieve restoration, with antibiotic treatment given at the same time.
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PMID:[Reconstructive surgery on eyeball injuries with iris prolapse (author's transl)]. 745 73


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