Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 27-year-old woman has been suffering from recurrent corneal edema without ocular hypertension since her early childhood. When the cornea is clear, visual acuity-with correction for high myopia-is 5/10 to 5/15 and Nieden I; when the cornea is swollen, it decrease to 5/50 and 1/10, respectively, and Nieden VII. Furthermore, there is an atypical pigment degeneration of the retina combined with deafness, a progressive ptosis since her 10th year of life, and a progressive dystrophy of the outer eye muscles, having developed in the past few years. In addition, the mentally normal developed patient presents a proportional dwarfism (no dysostosis) and a diabetes mellitus. This combination of symptoms is compared with the well known Bardet-Biedl syndrome and the De Grouchy syndrome and is found to constitute a new syndrome.
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PMID:[Recurrent corneal edema without ocular hypertension, pigment degeneration combined with deafness, progressive dystrophy of the outer eye-muscles in a patient with proportional dwarfism and diabetes mellitus (author's transl)]. 30 14

Improvement in the management of perforating injuries has become possible since the successful control of infection. However, the decisive step ahead was accurate suturing. The use of finer needles and of thinner, standardised suture material enabled accurate adaption of the margins and closer suturing. The anterior chamber could now be filled with air, thus preventing contact between iris and cornea. Development of new instruments enabled simultaneous management of haemorrhages and of injuries of the lens and vitreous body. Prolapse of iris without essential damage to the iris could be reduced either by limbal puncture or by intensive rinsing with fluid, proceeding from the edges of the wound. Parallel to the successful management of lens injuries a more radical form of vitreous surgery developed without significantly increasing surgical trauma. In Birmingham, during 1950--1958 45% of the patients with perforating injury of the anterior segment--including injury of the lens or iris--achieved a visual acuity of 6/12 or better. During 1971--1974 the corresponding percentage was 62% at the same clinic.
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PMID:[Concise review of progress in the management of perforating injury (author's transl)]. 39 23

Corneas for penetrating keratoplasty that have been excised from the globe for storage ordinarily require punching of the donor tissue from the posterior surface. They may be trephined from the anterior surface when they are mounted on an instrument that forms a seal around the scleral rim of the excised cornea, allowing the endothelium to be supported physically by the liquid storage medium. The artificial anterior chamber protected the endothelial cells from damage as if they were still in the intact globe. The instrument allowed trephination to any desired depth and facilitated the cutting of corneal buttons with a rim of Descemet's membrane and endothelium. Sutures may be preplaced in the donor button before the button is seperated completely from the rest of the cornea. Iris prolapse did not interfere with the procedure.
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PMID:An artificial anterior chamber. 79

A newly designed mechanical phacofragmentator powered by compressed air was tested on 200 human hard nuclear cataracts and ten traumatic owl monkey cataracts. The device, which consists of a turbine-driven diamond burr, successfully fragmented hard human cataracts, both in vitro and when implanted in the anterior chamber of rabbits and monkeys. Iatrogenic damage to the iris was noted in the early cases, but no collapse of the anterior chamber or gross damage of the cornea occurred. Iris damage can be avoided, once the operator gains sufficient skill in manipulating the instrument. The ten traumatic monkey cataracts were all removed without complication, except for one case in which the posterior lens capsule was ruptured with subsequent vitreous prolapse.
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PMID:Experimental cataract fragmentation:instrumentation and laboratory evaluation. 81 42

Fifteen years after a partial maxillectomy and radiation therapy for left antral carcinoma, a 53-year-old woman presented to the Eye Plastics and Orbit Service of the Massachusetts Eye and Ear Infirmary, Boston, with phthisis and a large, black corneal lesion in the left eye. She had been treated for unilateral glaucoma in the left eye for more than 10 years with topically administered epinephrine borate, timolol maleate, and pilocarpine hydrochloride. Clinically, the lesion was smooth, black, and homogeneous, and was thought to represent uveal prolapse covered by a thin layer of epithelium. An eyelid-sparing anterior exenteration was performed. Histopathologic examination revealed an acellular, homogeneous substance that stained positively with the Fontana Masson stain for melanin and bleached with potassium permanganate, findings consistent with corneal adrenochrome deposition. Since adrenochrome can be easily dissected free from the cornea, this case illustrates that misdiagnosing adrenochrome deposition may lead to unnecessary surgery.
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PMID:'Black cornea' after long-term epinephrine use. 152 Jan 15

Vitreous prolapse into the anterior chamber after cataract extraction is a severe complication in cases in which there is a contact between the vitreous and the cornea. The present paper discusses the result of treatment by vitrectomy in 15 patients with this complication. Anatomical and functional improvement was attained in 12 cases (89 p.c.) and in 5 among them--full visual acuity was obtained.
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PMID:[Vitrectomy in the treatment of vitreous body prolapse after cataract extraction]. 226

Using a surgical technique directed at the levator aponeurosis, we successfully corrected 228 cases of congenital ptosis. The advantages of this approach are: normal anatomic planes and structures of the eyelid are maintained; basic and reflex tear secretion, goblet cells, or meibomian glands remain undisturbed, allowing maintenance of the three-layered tear film; any aponeurotic defects may be explored and repaired relatively easily; all elevating structures are preserved (aponeurosis rather than muscular levator is removed, Mueller's muscle is left intact, Whitnall's ligament is not violated); posterior sutures, which may irritate the cornea, are avoided; no tarsus or conjunctiva are removed.
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PMID:The aponeurotic approach to congenital ptosis. 236 49

The correction of marked blepharoptosis in patients with severe or potential keratopathy will worsen the keratopathy and possibly lead to the complications of corneal ulceration and endophthalmitis. The conjunctival flap--cosmetic shell--ptosis procedure is well suited to this difficult management problem. Patients are initially treated with a conjunctival flap to protect their cornea. Subsequently they are fit with a cosmetic shell, and finally they undergo surgery to correct their ptosis. This three-stage procedure has produced excellent cosmetic and functional results in two patients, one of whom had ptosis and severe radiation-induced keratopathy following the treatment of a rhabdomyosarcoma; the other patient had severe ptosis associated with lack of corneal sensation and orbicularis function following removal of a cerebral meningioma.
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PMID:Conjunctival flap-cosmetic shell-ptosis procedure. Treatment of blepharoptosis in severe keratopathy. 259 74

Botulinum toxin A produces a temporary, flaccid ptosis when injected into the levator palpebrae superioris muscle. The resulting protective ptosis was used to aid healing in 21 cases of indolent ulceration, and, prophylactically, in 4 cases of neuroparalytic keratitis. Of the indolent ulcers, 90% healed completely. In all but one case, the cornea was covered completely by the lid and complete ptosis was produced in 75% of cases in an average of 3.6 days, lasting for 16 days on average before recovery began. Recovery of levator function was complete in 8.5 weeks on average. Superior rectus underaction was seen in 68% of cases but this recovered completely in all cases in an average of 6 weeks. Impression cytology showed a trend toward normal conjunctival morphology as healing progressed.
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PMID:Botulinum toxin A-induced protective ptosis in corneal disease. 305 Jun 91

In the last five years, 500 one-eyed patients have undergone cataract surgery at the authors' hospital. A Simcoe-type posterior chamber lens was implanted in 425 of the eyes. An eye was defined as an only eye if corrected vision in the fellow eye was 1/60 or less, or better vision in cases of amblyopia. The main causes of loss of function in partner eyes were macular degeneration, amblyopia, and glaucoma. The rate of intraoperative and postoperative complications was the same as in the entire patient collective, and in absolute terms actually lower. There were four cases of intraoperative rupture of the posterior capsule (in two of which it subsequently proved possible to fit a posterior chamber intraocular lens (PCIOL], and one case each of corneal decompensation and excessive hemorrhage into the anterior chamber. PCIOLs were subsequently also implanted in both these eyes. Early postoperative complications included several cases of iris prolapse, all of which were easily rectified, and intermittent phases of endothelial decompensation associated with cornea guttata. In view of the low overall rate of intraoperative and postoperative complications, the authors advocate implantation of a PCIOL in remaining eyes with visual function, except those with proliferative retinopathies (primarily diabetes mellitus), pre-existing retinal detachments (particularly in young men with myopia and a history of detachment in the fellow eye), and unregulated glaucoma.
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PMID:[Cataract operations on the remaining eye]. 322 54


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