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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A vast literature reports on the ability of some tumor tissues to preserve the receptorial system of the original cells, which can be an indication of hormonal dependence of tumors. The authors tried to determine in quantitative term the receptorial capacity of beta Estradiol 17 of the normal and of the pathological endometrium. 23 postmenopausal patients were investigated, 10 with adenocarcinoma of the uterus, 6 with uterine fibroleiomioma, 4 with genital prolapse, and 3 with recurrent metrorrhagia. The maximal receptorial concentration was found in the 10 patients with adenocarcinoma, with concentrations going from 39.8 to 86.3 femtomoli/mg proteins. The normal value of a normal endometrium would be from 22 to 60.2 femtomoli/mg proteins. Some hypotheses are advanced about the receptorial capacity of the pathological tissues studied.
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PMID:[17-beta estradiol receptors in the normal and pathological human uterus]. 42 39

A case is reported of a 60-year-old man, who developed an adenocarcinoma in the abdominal wall adjoining an ileostomy. Thirty-one years previously a total colectomy was performed for ulcerative colitis. Because of extensive prolapse the ileostomy was excised 6 years before the final operation, and a fresh part of the ileum, 10 cm proximal to the original stoma, was reimplanted in the abdominal wall at the same location. The pathogenesis of the malignant growth is uncertain; several possibilities as to the course of events at the ileostomy and surrounding skin are discussed.
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PMID:Adenocarcinoma arising at an ileostomy site: report of a case. 94 32

Mucinous cystadenocarcinoma of the appendix occurred with symptoms limited only to a total uterovaginal prolapse. Preoperative intravenous pyelogram and pelvic ultrasonography demonstrated the presence of a large pelvic mass. Exploratory laparotomy revealed the mass to be appendiceal adenocarcinoma, which was treated with extirpation of all the visible tumor and repair of the anatomic defect.
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PMID:Mucinous cystadenocarcinoma of the appendix with pseudomyxoma peritonei presenting as total uterine prolapse. A case report. 154 33

Four cases in which nabothian cysts extended deeply into the cervical wall are described. Well differentiated adenocarcinoma of the minimal-deviation type (adenoma malignum) was an initial diagnostic consideration in three of them. The cysts were incidental findings in patients 32 to 79 years of age, who underwent hysterectomy for uterine leiomyomas (two cases), uterine prolapse (one case), and a leiomyosarcoma of the pelvic soft tissues (one case). Gross examination of the cervix in each case revealed multiple mucin-filled cysts that extended almost to the serosa or paracervical connective tissue. On microscopic examination, the cysts were characteristic of nabothian cysts, being lined by columnar to flattened endocervical-type cells devoid of atypical features or mitotic activity. Postoperative follow-up, available in three patients, was uneventful over periods of 1, 6, and 10 years. Deep nabothian cysts are an uncommon nonneoplastic lesion of the cervix that is important to distinguish from adenocarcinoma.
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PMID:Deep nabothian cysts of the uterine cervix. A possible source of confusion with minimal-deviation adenocarcinoma (adenoma malignum). 280 13

The expression of six lectins (Arachis hypogaea, B. simplicifolia I, concanavalin A, Dolichus biflorus, Triticum vulgaris, Lotus tetragonolobus) was studied in 24 adenocarcinomas, 24 adenomas, 20 metaplastic polyps, 17 specimens of mucosal prolapse (solitary ulcer syndrome) and 10 of normal mucosa, all taken from the rectum. Qualitative, quantitative and distributive differences in lectin expression were observed between adenocarcinoma and normal mucosa. These cancer-associated glycoprotein alterations were also observed, though to a lesser extent, in benign neoplastic and non-neoplastic lesions of the rectum. It appears therefore that the glycoprotein modifications associated with malignant transformation are not specific indicators of malignancy. It is suggested that the common denominator is a disturbance in the activities of enzymes, particularly the glycosyl-transferases and glycosidases, involved in the biosynthesis of glycoprotein. This disturbance can occur in situations where cells are less differentiated either through developmental immaturity, rapid cellular division or neoplastic de-differentiation. These changes are therefore more likely to reflect the state of differentiation rather than the malignant nature of the cells. It is shown that the greater the deviation of the lesion from normal the greater the glycoprotein alterations. The potential usefulness of lectin expressions as predictive indicators of biological behaviour of adenocarcinomas of the large bowel needs further studies.
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PMID:Lectin expression in neoplastic and non-neoplastic lesions of the rectum. 321 93

The presence of mucosal hyperplasia and sialomucin goblet cell secretion (transitional mucosa) was assessed in various benign, premalignant and malignant colorectal tissues. Transitional mucosa was seen in diverticular disease, solitary ulcer syndrome of the rectum, ischaemic and irradiation colitis and other diseases including pneumatosis coli, endometriosis, haemorrhoids and a colostomy margin. Adenocarcinomas had a sulphomucin or mixed secretion pattern with transitional features in the adjacent mucosa mucosa (18/27). Premalignant adenomatous polyps showed mixed secretion with transitional glands incorporated in the stalk and sometimes in the adjacent mucosa. Epithelium showing dysplasia secreted sulphomucins and in amounts related to its degree of differentiation. Transitional mucosa may not be a primary premalignant phenomemon. The conclusion and unifying concept is that it is a secondary event related to goblet cell immaturity. This can occur, secondary to proliferation in mucosal inflammation, ischaemia and prolapse or as a phenotypic expression of growth derived from underlying dysplastic epithelium.
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PMID:High iron diamine-alcian blue mucin profiles in benign, premalignant and malignant colorectal disease. 322 Apr 65

The clinicopathologic features of nine patients with inflammatory polyps of the anorectal transition zone (inflammatory cloacogenic polyp, ICP) were reviewed. All polyps were characterized histologically by crypt hyperplasia and a thickened muscularis mucosa arising beneath a surface epithelium consisting of variable proportions of squamous, columnar, and often transitional epithelium. Tubulovillous architecture was characteristic. Sialomucin predominated over sulfomucin in eight of nine cases. One polyp displayed focal dysplasia and condylomatous features, while two others had associated hemorrhoids. Three cases had been previously diagnosed as adenomas. Seven patients were women, and two were men; their median age was 54 years (range, 17 to 85). Clinical presentation was most commonly intermittent rectal bleeding, and the clinical diagnosis was anal polyp or hemorrhoids in all cases. Six patients had the solitary rectal ulcer syndrome (SRUS) and/or evidence of mucosal prolapse. Papillomavirus was demonstrated by histochemical and immunohistochemical methods in one case in which multiple foci of dysplasia were also noted. Two patients had Crohn's disease, and the remaining patient had a coexistent adenocarcinoma located several centimeters proximal to his ICP. The pathologist and clinician must be aware that although ICP is often associated with SRUS/mucosal prolapse, it may occur in other clinical settings.
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PMID:Inflammatory cloacogenic polyp: relationship to solitary rectal ulcer syndrome/mucosal prolapse and other bowel disorders. 350 Jan 6

A postmenopausal patient with vaginal prolapse of the fallopian tube presented with an erroneous diagnosis of adenocarcinoma of the vaginal apex. Failure to consider fallopian tube prolapse in the differential diagnosis of vaginal adenocarcinoma led to an upper vaginectomy and subsequent complication of a ureterovaginal fistula. The differential diagnosis of adenocarcinoma of the vagina in the postmenopausal patient and the management of vaginal prolapse of the fallopian tube are discussed.
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PMID:Prolapsed fallopian tube masquerading as adenocarcinoma of the vagina in a postmenopausal woman. 400 16

Gastroduodenal intussusception is a rarely documented condition. A distinction has to be made between complete gastroduodenal intussusception (CGDI) and either prolapse of a pedunculated tumor through the pylorus or mucosal prolapse through the pylorus. CGDI usually occurs secondary to a pedunculated benign gastric tumor. More rarely the tumor is malignant. We report a case of CGDI associated with gastric adenocarcinoma. We emphasize diagnostic difficulties that can be generated by CGDI.
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PMID:[Gastroduodenal intussusception on gastric tumor]. 784 8

In the 1950s the treatment of ulcerative colitis was revolutionized by Brooke by way of a colectomy combined with an eversion ileostomy. This procedure is known to be associated with a number of complications that include skin excoriation, stenosis, intestinal obstruction, retraction or prolapse of the stoma, abscess and fistula formation, and ileitis. However, adenocarcinoma arising in the abnormally placed small intestinal mucosa 20 years or more after the initial operation is being increasingly recognized and reported. This article describes one such case and includes an extensive review of the current world literature on the subject of adenocarcinoma arising as a late complication of operation for ulcerative colitis.
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PMID:Primary adenocarcinoma in an ileostomy: a late complication of surgery for ulcerative colitis. 850 31


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