Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

New, poorly recognized echocardiographic findings were recorded in six patients with pericardial effusion. These findings were apparent prolapse of mitral and tricuspid valves, apparent systolic anterior motion of mitral valve, and midsystolic notching of pulmonic valve. Beat-to-beat variation of the dimensions of right and left ventricle and in the diastolic opening amplitude of the anterior mitral valve were present in cardiac tamponade. Substantial decrease or resolution of effusion resulted in disappearance of the observed abnormalities. Serial echographic studies before and after fluid resolution may prevent misleading echographic and clinical diagnoses.
JAMA 1976 Oct 25
PMID:New, poorly recognized echocardiographic findings. Occurrence in patients with pericardial effusion. 98 57

Although cardiac anomalies are well documented among children with Down's syndrome, data on the cardiac status of adults with Down's syndrome are sparse. Therefore, we performed cardiac auscultation and Doppler echocardiographic examinations in 35 asymptomatic adults with Down's syndrome. There were 25 men and ten women; their mean age (+/- SD) was 26 +/- 8 years. Only ten subjects (29%) had normal findings on examination. The most frequent abnormal findings were holosystolic mitral valve prolapse (MVP) in 20 subjects (57%) and mild aortic regurgitation in four subjects (11%). Of the 20 subjects with MVP, five had associated tricuspid valve prolapse, but none had notable mitral regurgitation. Thus, we found that the majority of asymptomatic adults with Down's syndrome had valvular heart abnormalities. The high frequency of MVP and aortic regurgitation suggests that these lesions may be specifically associated with Down's syndrome in adults.
JAMA 1987 Oct 02
PMID:High frequency of mitral valve prolapse and aortic regurgitation among asymptomatic adults with Down's syndrome. 295 21

At a meeting of the American College of Obstetricians and Gynecologi sts, D.M. Haynes and W.H. Pearse answered questions about the necessity of many hysterectomies. Pathological findings in the tissue are not the only legitimate reason for hysterectomy; prolapse, fibroids, and excessively heavy menstruation are also just causes for the operation. So is sterilization, although the operation is too drastic a way to recommend it routinely. For certain women, however, it is the best path. Also, having a hysterectomy can become something of a fad. If the ovaries are spared, there are usually no measurable hormonal changes. About 2/3 of U.S. hysterectomies are done abdominally, the rest vaginally. The Manchester operation, after which a patient still menstruates, is fairly common in England. No drastic increase in the number of hysterectomies has occurred over the past several years.
JAMA 1976 Jun 28
PMID:"Legitimacy" of hysterectomies remains subject of debate. 1225 99