Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Botulinum A exotoxin was recently approved for use in Canada. We describe the efficacy of botulinum toxin in the management of 235 patients with blepharospasm (mean age 64.3 years) and 130 patients with hemifacial spasm (mean age 60.4 years) treated at three Canadian ophthalmologic centres between 1984 and 1989. A total of 98% of the patients with blepharospasm and 100% of the patients with hemifacial spasm had significant relief of their symptoms; however, 11% of the former and 2% of the latter did not respond to the usual starting concentrations of the drug and needed stronger dosages for relief. The duration of relief varied widely in both groups. Up to 7% of patients had ineffective treatments but responded to subsequent injections. Analysis of variance and linear trend statistics showed that there were no changes in the mean duration of relief over the first several treatments for individual patients in either group. Side effects were transient and included ptosis, exposure keratitis, epiphora and strabismus.
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PMID:Treatment of blepharospasm and hemifacial spasm with botulinum A toxin: a Canadian multicentre study. 205 23

The paper contain criteria for the choice of the character and dosage of surgical intervention in treatment of children with the Marcus-Gunn's syndrome and strabismus. As a basis, the following conditions are assumed: the state of the motility of the patient's eye upwards, the angle of strabismus, the state of corneal sensitivity, the degree of ptosis in the state of rest and activation of facial expression. Considering the mentioned conditions, 14 children were operated on, predominantly at the age from 2 to 5 years. Repeated resection of the levator was made in 2 children because of hypoeffect. In all children the final result was satisfactory, no complications were observed.
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PMID:[The surgical characteristics of ptosis in the Marcus Gunn syndrome combined with strabismus]. 208 26

Rubinstein-Taybi syndrome is a rare multiple congenital anomaly (MCA) syndrome comprising mental and growth retardation, broad thumbs and big toes, and unusual face. The classical appearance is easy to recognize. It includes downslant of the palpebral fissures, epicanthal folds, ptosis, strabismus, highly arched palate, and apparently low-set angulated ears with thickened helices. The nose has a beaked appearance, broad fleshy bridge, deviated septum that is long, protruding below the level of the nasal alae with an associated short columella. Since the typical facial phenotype may not be obvious until late childhood, I have evaluated more than 40 cases of Rubinstein-Taybi syndrome, seen at varying ages from the newborn period through infancy, childhood, and adulthood, in order to learn more about the early facial appearance.
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PMID:Rubinstein-Taybi syndrome: the changing face. 211 76

Case report of four members of a family presenting a congenital fibrosis syndrome. The first case has the typical presentation with bilateral ptosis, bilateral hypotrophic, variable horizontal deviation, and restricted ocular movements in all directions. The second case has a unilateral ptosis with Marcus Gunn phenomenon and bilateral restriction of elevation. In the third case, the condition is purely unilateral and associated with a sensorimotor neuropathy. A fourth member presents a unilateral ptosis. Three other members have a simple strabismus without any oculomotor anomaly.
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PMID:[Congenital fibrosis of thr ocular muscles: a diagnosis for several clinical pictures]. 213 36

We performed 9 to 12 mm of recession of the superior oblique tendon for A-pattern strabismus in 10 patients. The average preoperative A-pattern measured 29.4 prism dioptres (PD), and the average pattern correction was 29.3 PD. All patients had a residual pattern of 6 PD or less (average 2.3 PD). No patient experienced significant underaction of the superior oblique, and other surgical complications, such as ptosis, Brown's syndrome, and laceration of the vortex vein or superior rectus, did not occur. The procedure corrected 14 to 40 PD of A-pattern. The amount of pattern corrected was correlated with the size of the preoperative A-pattern but not with the total amount of recession done. No significant shift in esodeviation in primary position was noted in the patients who underwent only superior oblique recession. The procedure appears to be of particular value in patients with moderate superior oblique overaction. The advantages of recession of the superior oblique tendon include the potential for reversibility and reoperation, low risk of induced superior oblique palsy, allowance for asymmetric surgery and potential for adjustable suture technique.
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PMID:Recession of the superior oblique tendon in A-pattern strabismus. 224 67

We report a distinct syndrome of eyelid ptosis, convergent strabismus, abdominal muscle defect, hip dislocation, cryptorchidism and developmental delay in two brothers. Consanguinity in their parents suggests autosomal recessive inheritance.
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PMID:Ptosis of eyelids, strabismus, diastasis recti, hip defect, cryptorchidism, and developmental delay in two sibs. 256 26

In the 1st part, the conditions for the coordinated use of both eyes are described. Strabism continues to be the major reason for disorders of binocular vision. Particularly, causes, simple diagnostic procedures and therapy of infantile squint (soncomitant strabismus) and of paretic squint are reported in detail. Further, ocular nystagmus as ocular symptom of diverse motor and sensorial disturbances is classified and described. Finally, the most important forms of congenital, myogenic, senile, traumatic and neurological ptosis are presented and the time of therapeutic approach is fixed.
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PMID:[Contribution of the pediatrician in the early diagnosis of eye diseases]. 266 18

We have used botulinum toxin (Oculinum) for the past 2 years to treat strabismus and other ophthalmic conditions. It was effective for blepharospasm and hemifacial spasm, and in producing pharmacological ptosis. There were a few local complications, such as ptosis and diplopia, which disappeared within a few weeks. This is a new treatment modality with specific indications in ophthalmology.
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PMID:[Use of botulinum toxin in ophthalmology]. 279 58

Thirty children suffering from the fetal alcohol syndrome (FAS) were compared with 22 matched controls regarding malformations of the eyes and the visual function. All mothers to the FAS children had a documented abuse of alcohol during pregnancy. It was not possible to get reliable, detailed data on drinking habits, nor could it be ruled out that some mothers might have used psychopharmaceutic drugs during periods of the pregnancy. Defects of the outer eye region, or intraocular abnormalities, or both, were found in 27 FAS children (90%). Anomalies of the outer region like ptosis and strabismus were frequently found in the FAS children but were not common in the controls. Abnormalities in the anterior segments and media were found in six eyes. Malformations of the fundus were the most frequently occurring abnormalities in the FAS children. Forty-eight per cent of the eyes showed hypoplasia of the optic nervehead and 49% had an abnormal tortuosity of the retinal arteries. These variables were studied quantitatively by a new photogrammetric method. There were serious consequences to the vision of the FAS children. Nineteen per cent of the eyes has a visual acuity of 0.2 (20/100) or less, and 46% had 0.3-0.6 (20/60-20/30). Almost all controls had normal vision. As maternal alcohol abuse during pregnancy was the only variable which could be traced in every case of FAS, it is appears very likely that alcohol caused the abnormalities of the eyes, possibly through non-specific, intra-uterine growth retardation. It that were the case, ocular abnormalities should be common in children with non-FAS growth retardation. A control study did not support this possibility.
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PMID:Ocular abnormalities in the fetal alcohol syndrome. 298 63

Malignant hyperthermia is a potentially fatal complication of general anesthesia that may occur with greater frequency in ptosis and strabismus surgery. The case of a two-year-old girl who suffered a malignant hyperthermia crisis during strabismus surgery is reported. The pathophysiology, clinical features, treatment and pre-anesthetic diagnosis are reviewed in detail.
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PMID:[Malignant hyperthermia in ophthalmologic surgery]. 307 76


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