Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0033377 (
prolapse
)
11,717
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Objective
: To review lower urinary tract symptoms (LUTS), which include a large variety of bladder complaints, in women with simultaneous pelvic organ
prolapse
(
POP
).
Methods
: This article is a systematic review of the current literature on LUTS occurring simultaneously with
POP
following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology.
Results
: The prevalence of both conditions is high, but they occur more frequently together than can be explained by chance. It appears that
POP
is in some women causative of overactive bladder (OAB) symptoms, as in many women correction of the
POP
resolves the bladder symptoms and small studies of women with detrusor underactivity also demonstrate resolution of symptoms. The most plausible explanation for the relationship is that
POP
causes bladder outlet obstruction, which results in excess bladder irritability or poor contractility. However, not all women have resolution of their OAB symptoms and some women develop them
de novo
after
POP
repair, so this explanation requires more in depth study.
Conclusions
: Women with both LUTS and symptomatic
POP
should probably have their
POP
targeted, as its reduction either via surgery or pessary can correct the LUTS. However, no studies have addressed asymptomatic
POP
, so it is unclear if treating
POP
in these instances is of benefit.
Abbreviations:
BOO
: bladder outlet obstruction; DO: detrusor overactivity; DU: detrusor underactivity; OAB: overactive bladder; P
det
Q
max
: detrusor pressure at maximum urinary flow;
POP
: pelvic organ
prolapse
; PVR: post-void residual urine volume; RR: relative risk; SUFU: Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction; UDS: urodynamic studies; (S)(U)UI: (stress) (urgency) urinary incontinence.
...
PMID:Systematic review of lower urinary tract symptoms occurring with pelvic organ prolapse. 3311 Jun 59
