Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033036 (APC)
 10,214 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 60-years-old (85 kg, 178 cm) coronary arterial disease patient having had acute myocardial infarction for several times received liver transplantation successfully. He had a previous episode of acute myocardial infarction associated with entire obstruction of right coronary 6 years ago, and was inserted a bracket then. One year ago the patient got chest pain again, and was diagnosed as inferior wall myocardial infarction. Then he received expectant treatment in internal medical department for several days. A 774HF75 PAC catheter (Edwards Lifescience, USA) was inserted into an internal jugular vein, and cardiac output, right ventricular end diastolic volume index, right ventricular ejection fraction, stroke volume index, system vascular resistance, pulmonary vascular resistance, left ventricular-stroke work index and right ventricular-stroke work index were calculated. During the operation, cardiovascular medications such as dopamine, norepinephrine, dobutamine were infused and adjusted by steps carefully. Electrolytes and acid-base balance were maintained normal. With these hemodynamic parameters, BGA and systemic management, the anesthesia was managed safely and successfully.
Beijing Da Xue Xue Bao Yi Xue Ban 2009 Apr 18
PMID:[A case report of perioperative management for liver transplantation in a patient with multiple old myocardial infarction]. 1937 38

In recent years, Wnt/beta-catenin signaling has been identified as a key player in embryogenesis and human diseases. Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt, beta-catenin, Axin, APC, GSK-3beta and CK1, which interact and coordinate to regulate the expressions of cell signaling molecules. The latest evidences suggest that some components of the Wnt/beta-catenin signaling, like APC, GSK-3beta, CK1, Dkk2 and WISE, play dual roles different from what they have been thought previously. Here we reviewed some recent discoveries on the canonical Wnt/beta-catenin signaling pathway to provide some new ideas and principles for signaling transduction studies.
Beijing Da Xue Xue Bao Yi Xue Ban 2010 Apr 18
PMID:[Dual-role regulations of canonical Wnt/beta-catenin signaling pathway]. 2039 73

Ubiquitin ligases are an important component in ubiquitination system, which can recognize substrate proteins specially to promote their degradation. Closely related to the generation and development of many tumors, ubiquitin ligases can regulate the growth, differentiation and apoptosis of cells by influencing protein stability, which makes them a potential new target for tumor molecular therapy. There are many kinds of ubiquitin ligases, mainly including APC/C and SCF complex. This article will introduce the structures and functions of these two kinds of ubiquitin ligases and their roles in the tumor generation and development.
Beijing Da Xue Xue Bao Yi Xue Ban 2010 Apr 18
PMID:[Relationship of ubiquitin-ligases APC/C and SCF complex to cancer]. 2039 74

Organ transplant has become one of the strategies for treatment of malignant disease. The transplant-related complications restricted the further development of organ transplantation; graft rejection is most prominent among these complications, which remains a major cause of morbidity and mortality after organ transplant. Toll like receptors 4 (TLR-4) has been shown as a key molecule in innate immunity and immune tolerance. The role of TLR4 in graft rejection after organ transplant is still unknown. This article will review the role and the mechanism of TLR4 to control APC mature, activate T cells, trigger immune attack to organ graft; therefore bring new insights into the pathophysiology of graft rejection and foster the development of new therapies to control graft rejection after organ transplant.
Zhejiang Da Xue Xue Bao Yi Xue Ban 2011 Sep
PMID:[TLR4 and organ transplant rejection]. 2198 51