Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033036 (APC)
 10,214 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Because sympathetic stimulation has been implicated in the genesis of arrhythmias, we studied the effects on arrhythmias of electroconvulsive therapy (ECT). Fifteen psychiatric patients (male: 8, female: 7, age: 19-51, mean: 29.8) without known heart disease underwent 24-hout Holter recordings before, during, and after ECT (25 episodes). All patients were taking psychotropic drugs and received atropine (0.4-1.2 mg, mean: 1.1 mg IV), methohexital, and succinylcholine prior to ECT. Following ECT, mean maximum heart rate increased (106 +/- 3.2 to 142 +/- 6.0 beats/min, p less than .001), PR interval decreased (149 +/- 3.3 to 131 +/- 3.7 msec, p less than .001) and QTc interval increased (132 +/- 6.5 to 454 +/- 9.7 msec, p less than .001) compared to values obtained after atropine administration. Mean PVC or PAC frequently immediately after ECT or per 24 hours did not change significantly (PVC per 24 hours 6.8 +/- 3.2 to 10.4 +/- 6.4, NS; PAC per 24 hours 0.4 +/- 0.3 to 0.3 +/- 0.2, NS) and no complex arrhythmias were noted. Rate and PR changes suggest adrenergic effects of ECT and QTc increase may be due to imbalanced sympathetic discharge. Autonomic stimulation produced by ECT did not induce arrhythmias in these patients without heart disease. The possible antiarrhythmic role of psychotropic agents or premedication is unknown.
 ...
PMID:Effect of electroconvulsive therapy on cardiac rhythm, conduction and repolarization. 8 30


Health PAC Bull
PMID:Worker's compensation: preventive care for industry. 14 36

The present study was undertaken to investigate the effect of a continuous calcium infusion on the plasma levels of aldosterone, renin activity, and cortisol in six anephric and four nonnephrectomized patients on regular hemodialysis. In both groups, a significant increase in whole blood ionized calcium (b-Ca2+) was demonstrated. A significant increase in plasma aldosterone (PAC) was noted in the nonnephrectomized patients, in whom the rise in PAC correlated with the increase in b-Ca2+. However, in the anephric patients only a smaller and insignificant increase in PAC was found. No significant changes were demonstrated in plasma cortisol or renin activity, nor in potassium or sodium concentrations in either group. It is concluded that ionized calcium influences the plasma levels of aldosterone in uremic patients on regular hemodialysis.
 ...
PMID:Calcium-dependent aldosterone secretion in anephric and nonnephrectomized patients on regular hemodialysis. 23 32

Bigeminal rhythms may arise from ectopic firing or from failure of impulse generation or conduction. In atrial bigeminy a premature atrial beat beat follows each sinus beat. If the PAC is not conducted bradycardia may result; if it is symptomatic treatment with digitalis or quinidine is indicated. Junctional bigeminy may be coupled to sinus beats or may accompany atrial fibrillation. Ventricular bigeminy, the most common type of bigeminy involving ectopic firing, usually requires treatment with suppressive drugs. Concealed bigeminy manifested as PVCs separated by an odd number of sinus beats has the same clinical implications as ventricular bigeminy. Re-entrant premature beats may also be triggered by an artificial ventricular pacemaker. Bigeminy associated with delayed impulse conduction is most often caused by a 3:2 Wenckebach block at the A-V junction but the block may also be at the S-A node or around an ectopic pacemaker. Conduction or production delay may produce "escape-capture" bigeminy in which successive beats are produced by the dominant pacemaker and an alternate one. Implantation of an artificial pacemaker may be appropriate. It is important for the observer to be able to identify the mechanism of any bigeminal rhythm since crucial clinical decisions may attend such identification.
 ...
PMID:The differential diagnosis of bigeminal rhythms. 24 29

The circadian rhythm of plasma aldosterone (PAC) and cortisol concentration (PCC), and renin activity (PRA) was measured in five steroid and five non-steroid treated kidney transplanted patients--all with denervated kidney grafts--and compared with four normal controls and two steroid-treated patients with non-renal disease and thus normal renal innervation. The non-steroid treated patients had a normal circadian thythm of PAC and PCC, but without variation of PRA, suggesting that denervation of the kidneys has no influence on the circadian rhythm of PAC. In both steroid treated groups the PAC showed an inverse diurnal variation--now correlating to the diurnal variation in PRA. The inverse circadian rhythm of PAC in patients with suppressed ACTH secretion remains unexplained, but is in accordance with the nocturnal peak of sodium and water excretion in steroid treated patients.
 ...
PMID:Circadian rhythm of plasma aldosterone and plasma renin activity in steroid and non-steroid treated kidney transplanted patients. 33 62

The following hematological and biochemical reference values were determined in 150 hares: hematocrit, blood count and leucocytic formula, Na, K, Cl, P, Ca, Mg, Cu, Zn, glucose, urea, creatinine, uric acid, cholesterol, bilirubin, triglycerides, proteins and fractions, PAL, PAC, TGO, TGP, amylase, GGT, LDH. Once the effects of sex and age have been established, the references defined here will be used as a base for interpreting disturbances linked either to pathology or nutrition.
 ...
PMID:[Contribution to the definition of reference values in the hare: hematology -- blood biochemistry (author's transl)]. 57 73


Health PAC Bull
PMID:NYC public hospitals. 79 29


Health PAC Bull
PMID:Swine flu: play it again, Uncle Sam. 80 Apr 13


Health PAC Bull
PMID:The depression and the AMA. 82 3


Health PAC Bull
PMID:Profits in medicine: the business of health is business. 82 33


1 2 3 4 5 6 7 8 9 10 Next >>