Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033036 (APC)
 10,214 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 44-year-old man was admitted to our hospital because of brain metastasis and intrapulmonary exacerbation of lung adenocarcinoma. Systemic chemotherapy (PAC + CBDCA) was administered, but neurological symptoms (muscle weakness of limbs and disorientation) appeared. Lumbar puncture and enhanced MRI of lumber vertebrae revealed meningeal carcinomatosis. MTX 20 mg/week (+ Ara-C 40 mg/week) was injected into the meningeal space. There was a clear improvement in the neurological symptoms, but it did not last long. Meningeal injection was performed 7 times. Whole-brain and whole-marrow radiation along with systemic chemotherapy gave a marked improvement in the symptoms and in the metastatic shadow on the chest CT scan.
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PMID:[A case of meningeal carcinomatosis from lung cancer successfully treated with aggressive multimodal therapy]. 1741 41

A 69-year-old man was admitted complaining of bloody sputum. A chest X-ray and CT revealed no abnormal findings, but bronchoscopy revealed a squamous cell carcinoma nodular lesion in the bifurcation between the left B(1+2)a and B(1+2)b. After two courses of chemotherapy (CBDCA + PAC), the nodular lesion disappeared. Another nodular squamous cell carcinoma grew in the orifice of the left B(1+2) nine months later, but this time chemotherapy was ineffective. The nodular tumor was cauterized twice with argon plasma coagulation, and no recurrence appeared for twenty-six months.
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PMID:[A case of bronchogenic carcinoma which obtained long-term relapse free survival by argon plasma coagulation]. 2005 85