Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033036 (APC)
 10,214 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Laryngeal carcinoma (LC) is the most commonly diagnosed malignancy and recently the incidence of this disease has increased. By means of the mRNA differential display method we identified a cDNA, Laryngeal carcinoma related gene 1 (LCRG1) which has significantly reduced expression in 40% (12/30) of primary LCs and in 6 of 10 various cancer cell lines. Northern Blot analysis showed that LCRG1 was expressed more abundantly in human heart, pancreas, skeletal muscle, and in murine testis, liver, brain and heart than in other tissues. The cDNA sequence of this gene is identical to part of the sequence of PAC HCIT75G16 clone (GenBank accession No. AC003042) from the chromosome band 17q12-21.1 which is one of the most common loss of heterozygosity (LOH) regions involved in LC, prostate cancer, etc. This gene is composed of six exons and spans about 60 kb of genomic DNA with a 3.4 kb mature transcript. The alignment of this gene with STS markers localized the gene to the previously identified tumor-suppressor locus D17S800-D17S930. The putative protein encoded by this gene is 288 amino acid with one potential site for phosphorylation by casein kinase II and no significant homology to any known proteins in the public databases. The primary tumor suppressive functions (proliferation rate,soft agar growth and tumor formation) were observed in a LC cell line (Hep-2) by lipofectin transfection. Together these data strongly suggest a potential role of LCRG1 contributing to the development of LC.
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PMID:Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. 1514 23

beta-catenin and APC are key components of Wnt signaling pathway. Moreover beta-catenin protein is an adhesion molecule, which exists in complex with E-cadherin. Although clinical impact of beta-catenin in laryngeal cancer is still unclear. Our purpose was to investigate an expression of beta-catenin and its possible prognostic value in laryngeal cancer. The group of 41 patients with laryngeal cancer, surgically treated with minimum 5 years observation, was multi-variously analysed. Paraffin-embedded tissue sections from each case were immunohistochemically stained with a monoclonal antibody raised against beta-catenin antigen. By univariate analysis expression of beta-catenin analysed on the front of laryngeal tumour proved to be significantly related to overall and disease free survival, which were shorter in cases with cytoplasmatic expression. Although there were co correlation with overall and disease free survival in assessment of beta-catenin examined in the middle of tumours. Expression of beta-catenin in the primary tumours was not associated with its size, nodal status, local and nodal recurrences and histological stage (grading). Analysis of beta-catenin protein expression enables the assessment of biology of laryngeal cancer and it can be a prognostic factor of overall and disease free survival, while measures on front tumour in patients with laryngeal cancer.
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PMID:[Expression of beta-catenin protein in laryngeal squamous-cell carcinoma]. 1573 81