Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033036 (APC)
 10,214 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A few aluminophosphate (AlPO) molecular sieves are synthesized hydrothermally under microwave irradiation and conventional electric heating. Less stable AlPO molecular sieves especially with large pore can be obtained preferentially in a short crystallization time because the inter-conversion of less stable phase into a more stable one is prohibited in short reaction time. The VFI transforms into AFI, and finally into APC, with the increase of reaction time since the relative stability is VFI < AFI < APC under the chosen reaction conditions. The relative stability can be explained with the pore size or by the framework density of each structure. Due to the rapid crystallization involved in the microwave method and instability of porous materials with large pore, these porous materials can be selectively synthesized by microwave irradiation. The synthesis of extra-large-pore VPI-5 using triethylamine is also reported for the first time, and the synthesized VPI-5 is very stable that can be dried at 100 degrees C at atmospheric pressure without the phase-transformation into AIPO-8.
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PMID:Phase transformations and phase-selective syntheses of aluminophosphate molecular sieves. 1768 90

Clostridium difficile is a common cause of health-care acquired diarrhea, resulting in a spectrum of disease from mild diarrhea to life-threatening illness. Sixty Lactobacillus strains were screened for anti-C. difficile activity using a co-culture method. Based on their ability to inhibit C. difficile, L. gasseri APC 678 and L. rhamnosus DPC 6111 were selected for study in a murine model of C. difficile infection. L. gasseri ATCC 33323, was included as a control. It was established that, relative to control mice not fed Lactobacillus, feeding with L. gasseri APC 678 resulted in a significant reduction by day 7 (8-fold, p = 0.017) of viable C. difficile VPI 10463 in the feces of mice. In contrast, neither L. rhamnosus DPC 6111 nor L. gasseri ATCC 33323 significantly reduced fecal C. difficile shedding. Sequencing of the cecal microbiota showed that in mice fed L. gasseri APC 678 there was a significant increase in bacterial diversity across a number of indices when compared to the control or other Lactobacillus-fed groups. There was no significant change in the relative abundance of Firmicutes or Bacteroidetes in the group fed L. gasseri APC 678 relative to the control, while the groups fed L. rhamnosus DPC 6111 or L. gasseri ATCC 33323 showed a significant decrease in the relative abundance of Firmicutes (p = 0.002 and p = 0.019, respectively) and a significant increase in Bacteroidetes (p = 0.002 and p = 0.023, respectively). These results highlight the potential of L. gasseri APC 678 as a live therapeutic agent to target C. difficile infection.
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PMID:Lactobacillus gasseri APC 678 Reduces Shedding of the Pathogen Clostridium difficile in a Murine Model. 3084 60