Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0033036 (
APC
)
10,214
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Several items characterize the papular acrodermatitis: 1. the clinical picture and the localisation 2. inguinal and axillary
lymphadenitis
3. acute usually anicteric hepatitis 4. presence of hepatitis B antigen in all patients. Other members of the family are carriers of HB-Ag, too. One of them usually had icteric hepatitis weeks before or after
PAC
. At present we consider
PAC
as the clinical disease due to the primary infection of HB-Ag in childhood. The cycle of HB Ag is shown in a scheme. It suggests why the disease is rare, asymptomatic infections occurring in the majority of the cases. It appears in children without HB-antibodies and a particular reactive condition. After parenteral inoculation
PAC
and
lymphadenitis
do not develop. Some chronic HB Ag carriers may have become so after
PAC
in the childhood.
...
PMID:Akrodermatitis papulosa infantilis. An Australia antigen disease. 83 58
