Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033036 (APC)
 10,214 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Longitudinal Cohort Study: Electrocardiogram and blood pressure were taken biannually along with history taking, physical examination and other laboratory studies. 6,690 subjects were included in this study in whom at least 7 out of 9 biannual check up examinations were performed. At the end of the study period, their ages ranged from about 40 to 90 years. The incidence of atrial fibrillation was about 0.2% in the forties and early fifties and increased to 0.6% by the late fifties. The incidence of atrial fibrillation was then increased almost linearly up to 2.5% at the end of the eighties. Likewise, incidence of CRBBB and LBBB was also increased with age even after the age of sixty; 1.0% at the fifties to 7.5% at the eighties in CRBBB and 0.05% at the fifties to 1.4% at the eighties in LBBB, respectively. Holter ECG Study: Holter ECG was recorded in 164 healthy subjects aged 14 to 87 years in whom no arrhythmias were found in the routine 12 leads ECG at entry to the study. In 96.9% of the subjects APC was recorded in the 24-hour Holter ECG irrespective of their age. The total number of APCs in 24 hours significantly increased with age, especially after age sixty. The incidence of couplet or short run APCs was 21.4% under age sixty and 74.2% above age sixty. Electrophysiologic Studies in Patients with Paroxysmal Atrial Fibrillation (Paf): Repetitive atrial firing (RAF) elicited by premature atrial stimulation, and prolonged intra-atrial electrogram (PAE) with multiple (more than 7) spikes recorded during sinus rhythm were taken as indicators of atrial vulnerability. RAF and PAE was observed in more than 60% of Paf patients with or without sick sinus syndrome (SSS), but only approximately 25% in the control group (without SSS). It was also noted that in patients with SSS, who were generally of old age, RAF was observed in about 63% even without Paf. These results suggest that the atrial vulnerability might be an expression of the common electrophysiologic properties of the atrial muscle in the elderly with atrial arrhythmias and/or SSS. Syncopal Episodes due to Transient Severe Hyperkalemia in the Elderly: Two patients with mild to moderate chronic renal failure developed transient severe hyperkalemia (9.9, 7.3 mEq/L, respectively), severe sinus bradycardia with sinus arrest and syncopal episodes. These transient findings almost completely improved in a few days by kayexatete and bicarbonate, and temporary back-up atrial pacing. Hyperkalemia was disproportionately severe compared to BUN and serum creatinine.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Arrhythmias in the elderly]. 267 51

Normal electrocardiographic criteria in the elderly are not well defined. The prevalence of electrocardiographic abnormalities is three times higher in subjects over 85 years than in subjects 65-69 years old. With aging the heart rate does not vary during rest and sinus rhythm is prevalent, although sinus pauses, overall at night, are frequently seen. First degree atrio-ventricular block is present in 8.1%-19% of the elderly. 11% of subjects over 70 years suffer from left anterior hemiblock. 4.3% of subjects over 65 years and 7% of those over 85 present a right bundle branch block. 1.7% of subjects older than 65 years and 9% of those older than 85 are affected by a left bundle branch block. Atrial ectopic contractions are present in 8.8% of subjects over 60 years and in all older subjects. Atrial fibrillation is more common as age increases, being found in 2% of under 75s, in 5% of all subjects over this age, in 14% over 85 years and in 27% of patients hospitalized or institutionalized aged over 90 years. The prevalence of ventricular ectopic contractions varies from 76% in studies performed with baseline electrocardiogram to 96% in studies performed with portable monitoring electrocardiogram. Major ST-T wave alterations are present in 6.3%-13% of the elderly. In 340 patients over 80 years, hospitalized for diseases, other than cardiovascular, we found atrial fibrillation in 27.9% of subjects, ectopic beats in 26.2%, first degree atrioventricular block in 8.5%, right bundle branch block in 11.2%, left bundle branch block in 5.9%, left anterior hemiblock in 8.2%, ST-T wave alterations in 23.8% of the population.
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PMID:[Changes in the electrocardiogram in the elderly patient. The limits between normality and pathology]. 770 41