Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033036 (APC)
 10,214 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The localization of alpha 2-receptors was determined by quantitative autoradiography using [125I]para-iodoclonidine ([125I]PIC) and [3H]para-aminoclonidine ([3H]PAC). In cortical tissue, [125I]PIC and [3H]PAC were equipotent in their capacity to bind sites recognized by oxymetazoline (preferentially binds to the alpha 2A receptor subtype). The iodinated ligand was about 10 times more potent than [3H]PAC for binding to the heterogenous receptor population labeled by ARC-239 (alpha 2B and alpha 2C). The density of [125I]PIC binding was found to be two-fold higher than that of [3H]PAC in many brain areas and the disparity was even greater in regions such as the dentate gyrus, stria terminalis, and granular layer of the cerebellum. By contrast, other regions of the brain such as the laterodorsal thalamic nucleus, the locus coeruleus, and several amygdaloid areas had equivalent levels of binding. These observations indicate that [3H]PAC has selectivity for the alpha 2A receptor subtype and thus offer a restricted view of alpha 2-adrenergic receptor distribution. The iodinated ligand provides a more complete picture of the overall alpha 2 receptor population.
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PMID:Alpha 2-agonist binding sites in brain: [125I]para-iodoclonidine versus [3H]para-aminoclonidine. 810 17

The aim of this study was to determine the effect of different ceramic thickness on heat generation during resin cement photo-activation by QTH (quartz-tungsten-halogen), LED (light emitting diode), and PAC (plasma arc-curing) LCUs (light curing units). The resin cement used was Rely X ARC (3M-ESPE), and the ceramic was IPS Empress Esthetic (Ivoclar-Vivadent), of which 0.7-, 1.4- and 2.0-mm thick disks, 0.8 mm in diameter were made. Temperature increase was recorded with a type-K thermocouple connected to a digital thermometer (Iopetherm 46). An acrylic resin base was built to guide the thermocouple and support the 1.0-mm thick dentin disk. A 0.1-mm thick black adhesive paper matrix with a perforation 6 mm in diameter was placed on the dentin to contain the resin cement and support the ceramic disks of different thicknesses. Three LCUs were used: QTH, LED and PAC. Nine groups were formed (n=10) according to the interaction: 3 ceramic thicknesses, 1 resin cement and 3 photo-activation methods. Temperature increase data were submitted to Tukey's test (5%). For all ceramic thicknesses, a statistically significant difference in temperature increase was observed among the LCUs, with the highest mean value for the QTH LCU (p<0.05). For all the LCUs, a thickness of 0.7 mm produced the highest temperatures (1.4 and 2.0mm, p<0.05). There was no difference in temperature values between the latter two thicknesses (p>0.05). The interaction of higher energy density with smaller ceramic thickness showed higher temperature increase values.
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PMID:Influence of light curing unit and ceramic thickness on temperature rise during resin cement photo-activation. 1942 Aug 77

This study evaluated the Knoop hardness of a dual-cured resin cement (Rely-X ARC) activated solely by chemical reaction (control group) or by chemical / physical mode, light-cured through a 1.5 mm thick ceramic (HeraCeram) or composite (Artglass) disc. Light curing was carried out using conventional halogen light (XL2500) for 40 s (QTH); light emitting diodes (Ultrablue Is) for 40 s (LED); and Xenon plasma arc (Apollo 95E) for 3 s (PAC). Bovine incisors had their buccal face flattened and hybridized. On this surface a rubber mold (5 mm in diameter and 1 mm in height) was bulk filled with the resin cement. A polyester strip was seated for direct light curing or through the discs of veneering materials. After dry storage in the dark (24 h 37 degrees C), the samples (n = 5) were sectioned for hardness (KHN) measurements, taken in a microhardness tester (50 gF load 15 s). The data were statistically analyzed by ANOVA and Tukey's test (alpha = 0.05). The cement presented higher Knoop hardness values with Artglass for QTH and LED, compared to HeraCeram. The control group and the PAC/Artglass group showed lower hardness values compared to the groups light-cured with QTH and LED. PAC/HeraCeram resulted in the worst combination for cement hardness values.
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PMID:Effect of light-curing method and indirect veneering materials on the Knoop hardness of a resin cement. 1968 42

This study investigated the effect of coinitiator solutions and self-adhesive resin cement on the early retention of glass-fiber posts. Cylindrical glass-fiber posts were luted into 40 incisor roots with different adhesion strategies (n = 10): SB2, Single Bond 2 + conventional resin cement (RelyX ARC); AP, Scotchbond Multipurpose Plus (SBMP) activator + primer + ARC; APC, SBMP activator + primer + catalyst + ARC; and UNI, self-adhesive cement (RelyX Unicem). Pull-out bond strength results at 10 min after cementation showed APC > UNI > SB2 = AP (P < 0.05). The adhesion strategy significantly affected early bonding to root canals.
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PMID:Adhesion strategy and early bond strengths of glass-fiber posts luted into root canals. 2289 80