Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032617 (polyuria)
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Human Gene/Protein
Aquaporin-2 mutant 12.3
AVP-NPII 12.1
AQP2 protein 11.1
AVPR2 10.9
bumetanide-sensitive Na-K-2Cl cotransporter 10.8
claudin 16 10.7
CLDN19 10.7
KCNJ1 10.6
vacuolar protein sorting 33B 10.5
arginine vasopressin V2 receptor 10.5
SLC12A1 10.5
aquaporin 2 10.5
arginine vasopressin-neurophysin II 10.3
CLCNKB 10.2
AQP2 10.0
ARHGAP4 10.0
glutamate decarboxylase GAD65 9.9
barttin 9.8
Claudin-16 9.8
MAGE-D 9.6
more...
Disease
Renal adenoma and carcinoma 13.3
Pancreatic islet cell adenoma 13.3
metastatic squamous cell carcinoma of the nasopharynx 13.3
Congenital Mesoblastic Nephroma 13.3
Acute toxic nephropathy 12.3
Acquired nephrogenic diabetes insipidus 12.3
Hypokalemic hypochloremic metabolic alkalosis 12.3
Prepyloric ulcer 12.3
Congenital nephrogenic diabetes insipidus 12.0
Central diabetes insipidus 11.9
Primary polydipsia 11.9
Gallbladder mucocele 11.8
Salmonella paratyphi infection 11.8
Acute nephropathy 11.8
Familial nephropathy 11.8
Secondary diabetes mellitus 11.8
Sudden acquired retinal degeneration 11.8
nephrogenic diabetes insipidus 11.5
Congenital rubella infection 11.3
adult craniopharyngioma 11.3
more...
Symptom
polyuria 13.3
polydipsia 12.6
generalised tiredness 11.8
nocturnal polyuria 11.0
CVA tenderness 10.5
Chronic vomiting 10.3
excessive urination 10.3
Pituitary enlargement 9.4
ketonuria 9.3
GI pain 9.1
dysorexia 9.0
intestinal pain 8.8
oliguria 8.3
renal pain 8.3
hyperosmia 8.2
lassitude 8.0
enuresis 7.9
carpopedal spasm 7.8
epigastric distress 7.8
stomach cramps 7.8
more...
Drug
Nivazol 11.3
Pitressin tannate 10.2
Demeclocycline 9.5
Lixivaptan 9.3
Bendazac 9.1
Amikacin sulfate 9.1
DDAVP 9.0
DDAVP 9.0
Tolvaptan 8.9
Carmofur 8.7
Pitressin 8.6
Conivaptan 8.0
Desmopressin acetate 7.9
Potassium citrate 7.6
Lantus 7.6
Trilostane 7.6
Parecoxib 7.5
Velban 7.1
Gallium nitrate 7.0
Rasburicase 6.9
more...
Enzyme
proprotein convertase 1 7.8
ADH 7.6
D-amino-acid oxidase 7.1
CDP-diacylglycerol synthase 6.7
alanine aminopeptidase 5.8
alcohol dehydrogenase 5.7
uridyltransferase 5.6
oxytocinase 5.5
renin 5.3
PRA 5.2
glycerophosphate acyltransferase 5.1
methylmalonyl-CoA mutase 4.7
N-acetylglucosaminyltransferase 4.4
angiotensin-converting enzyme 2 4.3
thyroid peroxidase 4.3
aromatic L-amino acid decarboxylase 4.3
thromboxane synthase 4.2
prostaglandin synthetase 4.1
glucose-6-phosphatase 4.1
galactokinase 4.1
more...
Compound
2-Bromoethylamine hydrobromide 10.8
2-Bromoethylamine hydrobromide 10.8
N-isopropylacetamide 10.5
Cortivazol 10.2
Lys-vasopressin 9.4
Dihydrotachysterol 9.1
TMTU 9.0
difluoroacetic acid 8.8
DTMA 8.5
Fludrocortisone 8.5
Phosphate ion 8.5
Desmopressin 8.4
Swertiamarin 8.3
Merbarone 8.3
Niguldipine 8.1
Hydroxylysine 7.6
Lithium 7.5
Benzamil 7.5
Fructosamine 7.5
Sodium saccharin 7.4
more...