Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0032463 (
polycythemia vera
)
3,374
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
JAK2
719
erythroid
324
Jak2
309
erythropoietin
280
Sep
227
hemoglobin
203
interferon
162
MPL
152
Calreticulin
105
tyrosine kinase
104
cytokine
98
Janus kinase 2
93
STAT
90
BCR
80
megakaryocyte
78
ABL
73
Mol
73
JAK1
70
BCR-ABL1
60
Janus kinase
56
lymphoid
54
CD34
54
IFN
54
granulocyte
47
TET2
46
thrombopoietin
44
alkaline phosphatase
42
MPN
42
interferon alpha
40
CML
40
cell surface receptor
39
ASXL1
39
She
38
thrombopoietin receptor
38
glycoprotein
37
STAT5
37
calreticulin
36
collagen
34
p53
34
interferon-alpha
31
thrombin
28
BCR/ABL
26
erythropoietin receptor
24
bcr
22
Pol
22
mast cell
21
PMS
21
Erythropoietin
20
IDH1
20
EZH2
20
von Willebrand factor
20
MPD
19
prothrombin
18
AML
18
histone deacetylase
17
MDS
17
non-Hodgkin's lymphoma
17
HES
17
KIT
16
fibrinogen
16
EPO
16
CBL
16
PDGFRA
15
IL-3
15
reserved
14
ferritin
14
IDH2
14
vascular endothelial growth factor
13
EPOR
13
X-chromosome
13
PDGFRB
13
thrombomodulin
13
lactate dehydrogenase
13
glucose-6-phosphate dehydrogenase
13
ATP
12
beta-thromboglobulin
12
TEL
12
DNMT3A
12
stem cell factor
12
HLA
12
more...
Disease
polycythemia vera
3374
essential thrombocythemia
1254
myeloproliferative disorders
825
primary myelofibrosis
742
myelofibrosis
638
cancer
463
chronic myeloid leukemia
417
thrombocytosis
337
leukemia
295
erythrocytosis
245
acute myeloid leukemia
214
polycythemia
177
myelodysplastic syndrome
175
anemia
159
acute leukemia
156
tumor
149
chronic myeloproliferative disorders
147
lymphoma
133
thrombocytopenia
94
multiple myeloma
92
Leukemia
78
pruritus
78
secondary polycythemia
77
ABL
73
Budd-Chiari syndrome
70
hypertension
54
HHT
50
chronic lymphocytic leukemia
50
Hodgkin's disease
47
chronic myelomonocytic leukemia
46
blast crisis
45
hematologic malignancies
41
mastocytosis
39
Mitchell
39
stroke
39
secondary myelofibrosis
37
chronic lymphocytic leukemia
36
erythroleukemia
36
chronic neutrophilic leukemia
34
myocardial infarction
34
acute lymphoblastic leukemia
34
Aujeszky's disease
32
myeloid leukemia
31
aplastic anemia
30
portal hypertension
29
myelosuppression
28
Thrombus
27
chronic eosinophilic leukemia
26
thalassemia
24
sickle cell disease
24
dysplasia
24
diabetes
23
iron deficiency
23
ischemia
22
refractory anemia
22
rheumatoid arthritis
21
Best
19
cirrhosis
19
non-Hodgkin's lymphoma
18
pancytopenia
18
paroxysmal nocturnal hemoglobinuria
17
lymphoblastic leukemia
17
eosinophilia
17
MDS
17
osteomyelofibrosis
16
telangiectasia
16
renal failure
15
cerebral infarction
15
trisomy 8
15
acute nonlymphocytic leukemia
15
iron deficiency anemia
15
pulmonary embolism
15
HIV
15
thrombocytopenic purpura
15
carcinoma
15
panmyelosis
14
trisomy
14
plaque
14
vascular disease
14
depression
14
more...
Symptom
splenomegaly
270
pain
46
fatigue
44
headache
41
abdominal pain
31
hepatomegaly
21
hepatosplenomegaly
20
diarrhea
18
dizziness
17
chorea
17
nausea
12
anorexia
11
dyspnea
11
anesthesia
10
vomiting
10
night sweats
9
weakness
7
discomfort
7
bone pain
7
paresthesia
6
erythema
6
discomfort
6
vertigo
6
paraparesis
6
numbness
5
seizures
5
chest pain
5
nausea and vomiting
4
cyanosis
4
intestinal bleeding
4
Ill
4
angina
4
cough
3
clubbing
3
asthenia
3
insomnia
3
back pain
3
acute abdomen
3
abdominal discomfort
3
cachexia
3
arthralgia
2
syncope
2
sleepiness
2
tremor
2
blurred vision
2
regurgitation
2
ataxia
2
dry skin
2
lightheadedness
2
decreased appetite
2
functional recovery
2
ophthalmoplegia
2
hemoptysis
2
hemiplegia
2
paresis
2
myalgia
2
analgesia
2
tingling
2
polyuria
1
chronic cough
1
tachypnea
1
Amaurosis fugax
1
acidity
1
right upper quadrant pain
1
memory loss
1
respiratory distress
1
disturbed balance
1
lumbar back pain
1
dry eye
1
shoulder pain
1
finger pain
1
livedo
1
Severe pain
1
atypical chest pain
1
sneezing
1
asynergy
1
shortness of breath
1
arm pain
1
wheezing
1
spasm
1
more...
Drug
Dermatol
35
Cardiovasc
19
MDS
17
Anagrelide
16
CSF
11
Imatinib
10
PTH
7
TEL
6
G-CSF
6
IL-2
5
Gleevec
5
VCR
4
IFN-gamma
4
nitroglycerin
4
Nephron
4
IL-11
3
caffeine
3
LCM
3
Leaf
3
Nephron
3
LCM
3
Coumadin
2
MAP
2
SMP
2
Vitamin B12
2
ROC
2
Erlotinib
2
CTX
2
Lenalidomide
2
Hypaque
2
NADH
2
MRC
2
Hypaque
2
Pegasys
2
PPA
2
Monit
2
Palmitoyl
2
Portal
2
Digitalis
1
RFP
1
Vitamin K
1
ALA
1
AMC
1
Interferon alfa-2a
1
pyridoxal phosphate
1
Diamminedichloroplatinum
1
Norplant
1
Mutagen
1
Vorinostat
1
Asn
1
Prednisone
1
Paraffin
1
Adenosine deaminase
1
Check
1
Aprotinin
1
Glide
1
Orphan
1
Ranimustine
1
Fluorescein
1
ENT
1
Madopar
1
Ringer's solution
1
Argatroban
1
Clopidogrel
1
Gastro
1
Doxycycline
1
Fondaparinux
1
Glutathione
1
DDAVP
1
DDAVP
1
ETS
1
Rituximab
1
Tarceva
1
Fluorescein
1
Acitretin
1
vitamin E
1
Antithrombin III
1
PMEA
1
DOXY
1
Adriamycin
1
more...
Enzyme
focal adhesion kinase
834
ERK
56
alkaline phosphatase
42
thrombin
27
peroxidase
20
APC
17
mitogen-activated protein kinase
17
lactate dehydrogenase
15
reverse transcriptase
14
glucose-6-phosphate dehydrogenase
14
protein kinase
10
thromboplastin
8
tissue plasminogen activator
7
RNase
6
alanine aminotransferase
6
aspartate aminotransferase
6
RNase
6
ribonucleotide reductase
5
DNA polymerase
5
tryptase
5
catalase
5
protein kinase C
4
thymidine kinase
4
acetylcholinesterase
4
ribonucleotide reductase
4
plasmin
4
farnesyltransferase
3
farnesyltransferase
3
lysozyme
3
superoxide dismutase
3
RNA polymerase
3
beta-galactosidase
3
luciferase
3
NOS
3
thyroid peroxidase
3
transcriptase
3
trypsin
3
choline acetyltransferase
3
PRA
3
ribonuclease
3
glutathione reductase
3
phosphoglycerate kinase
3
CD13
3
ribonuclease
3
DNA methyltransferase
3
neutrophil elastase
2
gamma-glutamyl transpeptidase
2
CYP3A4
2
PGM
2
caspase-3
2
ACS
2
lipoxygenase
2
NQO1
2
methylenetetrahydrofolate reductase
2
calcineurin
2
MEK
2
glyceraldehyde-3-phosphate dehydrogenase
2
methylenetetrahydrofolate reductase
2
cholinesterase
2
ATPase
2
MAP
2
acid phosphatase
2
MIP
2
glutathione peroxidase
2
MMP-3
2
phosphofructokinase
2
endoglycosidase H
2
neuraminidase
2
PARP
2
CD10
2
proteasome
2
endonuclease
2
urokinase-type plasminogen activator
2
phosphodiesterase
2
ACE
2
SMP
2
renin
2
p-nitrophenylphosphatase
1
kallikrein
1
elastase
1
more...
Compound
Clin
268
Dec
200
DNA
164
BCR
80
oxygen
75
ABL
73
iron
66
tyrosine
49
Hydroxyurea
47
phosphorus
39
ASA
23
Phe
18
calcium
17
His
17
ADP
16
Hemoglobin
14
sodium
13
Cardiol
13
urea
13
water
13
Busulfan
13
ATP
12
nitric oxide
11
valine
11
glucose
10
ADP
10
ADP
10
creatinine
10
acetate
9
phosphate
9
serine
9
threonine
9
SET
8
MCNU
8
arginine
7
PEG
7
leucine
7
PEG
7
TEL
6
zinc
6
CO2
6
cysteine
6
SDS
6
PAS
5
Thrombin
5
methionine
4
glutamate
4
nitrogen
4
TNF
4
DPG
4
LCR
4
EDTA
4
GABA
4
DPG
4
GABA
4
Pipobroman
4
sulfate
4
EDTA
4
T10
4
MEP
3
A 42
3
T11
3
Ara-C
3
GSH
3
glycerol
3
NADPH
3
Ile
3
AMP
3
TEM
3
Asp
3
aspartic acid
3
MDA
3
lysine
3
hydroxide
3
retinoic acid
3
Warfarin
3
alanine
3
ethanol
3
boron
3
PGE2
3
more...