Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032463 (polycythemia vera)
 3,374 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
JAK2 719
erythroid 324
Jak2 309
erythropoietin 280
Sep 227
hemoglobin 203
interferon 162
MPL 152
Calreticulin 105
tyrosine kinase 104
cytokine 98
Janus kinase 2 93
STAT 90
BCR 80
megakaryocyte 78
ABL 73
Mol 73
JAK1 70
BCR-ABL1 60
Janus kinase 56
IFN 54
lymphoid 54
CD34 54
granulocyte 47
TET2 46
thrombopoietin 44
MPN 42
alkaline phosphatase 42
CML 40
interferon alpha 40
ASXL1 39
cell surface receptor 39
She 38
thrombopoietin receptor 38
STAT5 37
glycoprotein 37
calreticulin 36
collagen 34
p53 34
interferon-alpha 31
thrombin 28
BCR/ABL 26
erythropoietin receptor 24
bcr 22
Pol 22
PMS 21
mast cell 21
von Willebrand factor 20
Erythropoietin 20
EZH2 20
IDH1 20
MPD 19
AML 18
prothrombin 18
non-Hodgkin's lymphoma 17
histone deacetylase 17
MDS 17
HES 17
CBL 16
fibrinogen 16
KIT 16
EPO 16
IL-3 15
PDGFRA 15
IDH2 14
reserved 14
ferritin 14
thrombomodulin 13
lactate dehydrogenase 13
vascular endothelial growth factor 13
PDGFRB 13
EPOR 13
X-chromosome 13
glucose-6-phosphate dehydrogenase 13
B12 12
ATP 12
RUNX1 12
LDH 12
JAK3 12
STAT3 12
TEL 12
HLA 12
granulocyte colony-stimulating factor 12
DNMT3A 12
phosphatase 12
cytokine receptor 12
stem cell factor 12
beta-thromboglobulin 12
FGFR1 11
peroxidase 11
platelet factor 4 11
mTOR 11
CMPD 11
chronic renal failure 11
granulocyte-macrophage 11
factor V 10
antithrombin III 10
AKT 10
protein S 10
ABL1 10
ADP 10
myeloperoxidase 10
GM-CSF 10
tissue factor 10
bcr/abl 10
factor V Leiden 10
Cytokine 10
Lnk 10
kit 10
MRI 10
CD11b 9
FLT3 9
protein C 9
IgA 9
P32 9
transferrin receptor 8
white cell 8
axonal 8
SET 8
Hop 8
JAK-2 8
SF3B1 8
factor VIII 8
myelo 8
c-kit 8
PI3K 8
CD177 8
MDM2 8
U2AF1 8
janus kinase 2 8
hemochromatosis 8
CEL 8
PTH 7
ALL 7
cryptic 7
NF-E2 7
P-selectin 7
albumin 7
tumor necrosis factor 7
NF1 7
CD68 7
BCAM 7
insulin 7
MAPK 7
C-reactive protein 7
perlecan 7
FAB 7
PEG 7
thromboplastin 7
methemoglobin 7
IL-6 7
Epo receptor 7
plasminogen activator inhibitor-1 6
cyclooxygenase 6
leukocyte interferon 6
GPIIb 6
fibronectin 6
CD8 6
platelet-derived growth factor 6
GPIIIa 6
more...
Disease
polycythemia vera 3374
essential thrombocythemia 1254
myeloproliferative disorders 825
primary myelofibrosis 742
myelofibrosis 638
cancer 463
chronic myeloid leukemia 417
thrombocytosis 337
leukemia 295
erythrocytosis 245
acute myeloid leukemia 214
polycythemia 177
myelodysplastic syndrome 175
anemia 159
acute leukemia 156
tumor 149
chronic myeloproliferative disorders 147
lymphoma 133
thrombocytopenia 94
multiple myeloma 92
Leukemia 78
pruritus 78
secondary polycythemia 77
ABL 73
Budd-Chiari syndrome 70
hypertension 54
HHT 50
chronic lymphocytic leukemia 50
Hodgkin's disease 47
chronic myelomonocytic leukemia 46
blast crisis 45
hematologic malignancies 41
mastocytosis 39
stroke 39
Mitchell 39
secondary myelofibrosis 37
erythroleukemia 36
chronic lymphocytic leukemia 36
myocardial infarction 34
acute lymphoblastic leukemia 34
chronic neutrophilic leukemia 34
Aujeszky's disease 32
myeloid leukemia 31
aplastic anemia 30
portal hypertension 29
myelosuppression 28
Thrombus 27
chronic eosinophilic leukemia 26
dysplasia 24
sickle cell disease 24
thalassemia 24
diabetes 23
iron deficiency 23
refractory anemia 22
ischemia 22
rheumatoid arthritis 21
Best 19
cirrhosis 19
non-Hodgkin's lymphoma 18
pancytopenia 18
MDS 17
lymphoblastic leukemia 17
eosinophilia 17
paroxysmal nocturnal hemoglobinuria 17
osteomyelofibrosis 16
telangiectasia 16
carcinoma 15
thrombocytopenic purpura 15
cerebral infarction 15
iron deficiency anemia 15
pulmonary embolism 15
HIV 15
trisomy 8 15
acute nonlymphocytic leukemia 15
renal failure 15
trisomy 14
minimal residual disease 14
hemolytic anemia 14
vascular disease 14
plaque 14
panmyelosis 14
depression 14
cold 14
proteinuria 13
psoriasis 13
liver disease 13
trisomy 9 13
systemic lupus erythematosus 13
infectious diseases 13
obesity 13
immunodeficiency 12
esophageal varices 12
tumorigenesis 12
graft-versus-host disease 12
deep vein thrombosis 12
osteosclerosis 12
virus infection 12
disseminated intravascular coagulation 11
lymphoproliferative disorders 11
pulmonary hypertension 11
spinal cord compression 11
leg ulcers 11
CMD1 11
chronic renal failure 11
renal disease 11
HES 10
rare disease 10
varices 10
secondary AML 10
pyoderma gangrenosum 10
herpes simplex 10
herpes 10
antiphospholipid syndrome 10
tuberculosis 10
heart disease 10
osteomyelosclerosis 9
chronic leukemia 9
abortion 9
breast cancer 9
atherosclerosis 9
hyperlipidemia 9
Hippel 9
nephrotic syndrome 9
B-cell lymphoma 9
juvenile myelomonocytic leukemia 9
hemochromatosis 9
ulcerative colitis 9
plasmacytosis 8
hyperthyroidism 8
atopic dermatitis 8
melanoma 8
hypercalcemia 8
chronic obstructive pulmonary disease 8
pneumonia 8
acute myocardial infarction 8
gammopathy 8
Infection 8
gangrene 8
hemoglobinopathies 8
sarcoidosis 8
neuropathy 7
glomerulonephritis 7
sideroblastic anemia 7
rash 7
sepsis 7
hyperviscosity syndrome 7
vasculitis 7
sepsis 7
dermatomyositis 7
idiopathic thrombocytopenic purpura 7
hepatocellular carcinoma 7
glomerulosclerosis 7
von Willebrand disease 7
influenza 7
prostate cancer 7
coronary thrombosis 7
essential thrombocytopenia 7
congestive heart failure 7
xerosis 6
RAEB 6
more...
Symptom
splenomegaly 270
pain 46
fatigue 44
headache 41
abdominal pain 31
hepatomegaly 21
hepatosplenomegaly 20
diarrhea 18
dizziness 17
chorea 17
nausea 12
dyspnea 11
anorexia 11
vomiting 10
anesthesia 10
night sweats 9
discomfort 7
weakness 7
bone pain 7
paresthesia 6
erythema 6
discomfort 6
vertigo 6
paraparesis 6
seizures 5
numbness 5
chest pain 5
nausea and vomiting 4
cyanosis 4
intestinal bleeding 4
Ill 4
angina 4
cough 3
clubbing 3
asthenia 3
insomnia 3
back pain 3
acute abdomen 3
abdominal discomfort 3
cachexia 3
arthralgia 2
syncope 2
sleepiness 2
tremor 2
blurred vision 2
regurgitation 2
hemiplegia 2
hemoptysis 2
myalgia 2
functional recovery 2
tingling 2
analgesia 2
ataxia 2
ophthalmoplegia 2
decreased appetite 2
dry skin 2
paresis 2
lightheadedness 2
polyuria 1
chronic cough 1
tachypnea 1
Amaurosis fugax 1
acidity 1
right upper quadrant pain 1
memory loss 1
respiratory distress 1
disturbed balance 1
dry eye 1
flushing 1
Severe pain 1
collapse 1
shoulder pain 1
heartburn 1
finger pain 1
livedo 1
twitching 1
hypoproteinemia 1
lumbar back pain 1
hypothermia 1
asynergy 1
hot flushes 1
wheezing 1
shortness of breath 1
arm pain 1
physical symptom 1
lethargy 1
chills 1
prickling sensation 1
ENT 1
pallor 1
general problem 1
polydipsia 1
atypical chest pain 1
forgetfulness 1
sneezing 1
neck pain 1
exertional dyspnea 1
agitation 1
leg pain 1
spasm 1
hypotonia 1
stridor 1
chromosome marker 1
ankle pain 1
stomach pain 1
constipation 1
Drug
Dermatol 35
Cardiovasc 19
MDS 17
Anagrelide 16
CSF 11
Imatinib 10
PTH 7
G-CSF 6
TEL 6
Gleevec 5
IL-2 5
VCR 4
nitroglycerin 4
IFN-gamma 4
Nephron 4
Leaf 3
caffeine 3
IL-11 3
LCM 3
Nephron 3
LCM 3
Palmitoyl 2
Coumadin 2
MAP 2
ROC 2
Hypaque 2
Erlotinib 2
CTX 2
Hypaque 2
Lenalidomide 2
NADH 2
Vitamin B12 2
SMP 2
Pegasys 2
PPA 2
MRC 2
Monit 2
Portal 2
Digitalis 1
RFP 1
Vitamin K 1
ALA 1
AMC 1
Interferon alfa-2a 1
pyridoxal phosphate 1
Diamminedichloroplatinum 1
Norplant 1
Mutagen 1
Vorinostat 1
Asn 1
Prednisone 1
Paraffin 1
Check 1
HPMPC 1
PTC 1
Aprotinin 1
Orphan 1
FeCl3 1
Ranimustine 1
Fluorescein 1
ENT 1
Tipifarnib 1
Ringer's solution 1
Gelfoam 1
Fondaparinux 1
Glutathione 1
Clopidogrel 1
PCB 1
Gastro 1
Doxycycline 1
IHMS 1
DDAVP 1
Captopril 1
DDAVP 1
Adenosine deaminase 1
ETS 1
Rituximab 1
Tarceva 1
Fluorescein 1
Acitretin 1
Thioguanine 1
Glide 1
vitamin E 1
Madopar 1
Antithrombin III 1
PMEA 1
ROS 1
Argatroban 1
DOXY 1
Adriamycin 1
TAT 1
Alliance 1
NVP 1
Tocopherol 1
Bestatin 1
Lepirudin 1
Histamine 1
Enzyme
focal adhesion kinase 834
ERK 56
alkaline phosphatase 42
thrombin 27
peroxidase 20
APC 17
mitogen-activated protein kinase 17
lactate dehydrogenase 15
reverse transcriptase 14
glucose-6-phosphate dehydrogenase 14
protein kinase 10
thromboplastin 8
tissue plasminogen activator 7
alanine aminotransferase 6
RNase 6
aspartate aminotransferase 6
RNase 6
ribonucleotide reductase 5
tryptase 5
DNA polymerase 5
catalase 5
ribonucleotide reductase 4
acetylcholinesterase 4
plasmin 4
thymidine kinase 4
protein kinase C 4
thyroid peroxidase 3
beta-galactosidase 3
NOS 3
PRA 3
phosphoglycerate kinase 3
lysozyme 3
trypsin 3
transcriptase 3
farnesyltransferase 3
choline acetyltransferase 3
ribonuclease 3
glutathione reductase 3
RNA polymerase 3
farnesyltransferase 3
luciferase 3
ribonuclease 3
DNA methyltransferase 3
CD13 3
superoxide dismutase 3
methylenetetrahydrofolate reductase 2
MAP 2
MIP 2
ACS 2
CYP3A4 2
MEK 2
proteasome 2
glyceraldehyde-3-phosphate dehydrogenase 2
SMP 2
ATPase 2
acid phosphatase 2
caspase-3 2
urokinase-type plasminogen activator 2
endonuclease 2
phosphodiesterase 2
CD10 2
endoglycosidase H 2
glutathione peroxidase 2
MMP-3 2
cholinesterase 2
gamma-glutamyl transpeptidase 2
neutrophil elastase 2
ACE 2
lipoxygenase 2
neuraminidase 2
PGM 2
phosphofructokinase 2
NQO1 2
PARP 2
methylenetetrahydrofolate reductase 2
calcineurin 2
renin 2
hypoxanthine-guanine phosphoribosyltransferase 1
kallikrein 1
TdT 1
phosphoinositide 3-kinase 1
elastase 1
sialyltransferase 1
adenylate cyclase 1
sialyltransferase 1
sialyltransferase 1
DTA 1
chymase 1
glyceraldehyde-3-phosphate dehydrogenase 1
alpha-amylase 1
glutathione S-transferase 1
TSA 1
lactic acid dehydrogenase 1
MDP 1
enolase 1
cathepsin S 1
phosphoglucomutase 1
chloramphenicol acetyltransferase 1
12-lipoxygenase 1
protein phosphatase 2A 1
pyruvate kinase 1
PTA 1
carboxylesterase 1
isocitrate dehydrogenase 1
phosphatidylinositol 4-kinase 1
TAT 1
RNase H 1
AST 1
creatine kinase 1
tyrosine hydroxylase 1
isocitrate dehydrogenase 1
NADPH-diaphorase 1
histone demethylase 1
S1 nuclease 1
lipoprotein lipase 1
topoisomerase 1
NO synthase 1
diaphorase 1
topoisomerase 1
glutamine synthetase 1
phosphoglyceromutase 1
phospholipase A2 1
ceruloplasmin 1
hexokinase 1
p-nitrophenylphosphatase 1
enzyme X 1
PDE 1
nicotinamide phosphoribosyltransferase 1
nucleotidase 1
phospholipase C 1
SPC 1
diaphorase 1
beta-lactamase 1
6-phosphogluconate dehydrogenase 1
glyceraldehyde-3-phosphate dehydrogenase 1
adenylate kinase 1
Hageman factor 1
PHT 1
cdc2 1
phospholipase D 1
apyrase 1
cathepsin G 1
arginase 1
5'-nucleotidase 1
glyceraldehyde-3-phosphate dehydrogenase 1
ornithine decarboxylase 1
tyrosinase 1
6-phosphogluconate dehydrogenase 1
BAT 1
collagenase 1
histidine decarboxylase 1
lactic acid dehydrogenase 1
phosphatidylinositol 3-kinase 1
glyceraldehyde-3-phosphate dehydrogenase 1
PAH 1
arachidonate 5-lipoxygenase 1
dihydropyrimidine dehydrogenase 1
aldolase 1
lactic acid dehydrogenase 1
poly(A) polymerase 1
more...
Compound
Clin 268
Dec 200
DNA 164
BCR 80
oxygen 75
ABL 73
iron 66
tyrosine 49
Hydroxyurea 47
phosphorus 39
ASA 23
Phe 18
His 17
calcium 17
ADP 16
Hemoglobin 14
water 13
Busulfan 13
urea 13
Cardiol 13
sodium 13
ATP 12
valine 11
nitric oxide 11
ADP 10
ADP 10
creatinine 10
glucose 10
acetate 9
threonine 9
phosphate 9
serine 9
SET 8
MCNU 8
leucine 7
PEG 7
PEG 7
arginine 7
cysteine 6
zinc 6
CO2 6
SDS 6
TEL 6
PAS 5
Thrombin 5
glutamate 4
sulfate 4
methionine 4
Pipobroman 4
DPG 4
GABA 4
LCR 4
nitrogen 4
GABA 4
TNF 4
EDTA 4
T10 4
EDTA 4
DPG 4
Histone 3
cobalt 3
MEP 3
Ile 3
glycerol 3
Ara-C 3
aspartic acid 3
TXA2 3
galactose 3
A 42 3
Neuronal 3
aspartic acid 3
potassium 3
aspartic acid 3
lysine 3
hydroxide 3
Ara-C 3
proline 3
T11 3
retinoic acid 3
GSH 3
MDA 3
NH2 3
Reticulin 3
alanine 3
aspartic acid 3
Asp 3
TEM 3
caffeine 3
NADPH 3
GSH 3
PGE2 3
boron 3
ethanol 3
5-HT 3
NADPH 3
copper 3
Warfarin 3
2,3-diphosphoglycerate 3
nitrate 3
Tyrosine 3
MEP 3
AMP 3
Chlorambucil 3
dUTP 2
CMP 2
iodine 2
Optimal 2
N-acetylcysteine 2
NADH 2
Bordeaux 2
Azathioprine 2
pentose 2
glucose-6-phosphate 2
Dexamethasone 2
pentose 2
selenium 2
pentose 2
PPA 2
salt 2
prostacyclin 2
MAP 2
CMK 2
CTX 2
COS 2
ACTH 2
Fibrin 2
TTP 2
TOF 2
ACS 2
TCA 2
Pac 2
PMA 2
SSD 2
PGD2 2
Prone 2
GTP 2
TET 2
Glutamate 2
Hypaque 2
MCA 2
pentose 2
Cereb 2
MEK 2
TET 2
chromium 2
CMP 2
PMA 2
PPA 2
ACS 2
Neo 2
Nodular 2
GSSG 2
Mg2+ 2
bromide 2
MCA 2
GPT 2
Pyrazofurin 1
DIC 1
dCTP 1
CCNU 1
more...