Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032463 (polycythemia vera)
 3,374 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Studies of hemodynamics in 22 patients with Fallot's tetrade in the operative and early post-operative periods were analysed. The stroke and cardiac output were studied in all patients as well as the pressure in the cavities of the heart with subsequent calculation of coefficients PRV/PLV, PPA/PRV, and P.P-Q diagrams were constructed to characterize the pathophysiological processes in the heart ventricles. Correction of the anomaly was considered adequate in PRV/PLV less than or equal to 0.6. Coefficient PRV/PLV greater than 0.6 calls for additional analysis for the purpose of identifying residual stenosis or blood dumping at the level of the interventricular septum.
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PMID:[Cardio-hemodynamics in patients with Fallot's tetrad during operative and early postoperative period]. 281 Nov 68

The purpose of this investigation was to assess the effects of acute hypoxia on left (LV) and right ventricular (RV) contractility in clinically stable chronic obstructive pulmonary disease (COPD) patients. Eleven male patients (mean age 52.4 +/- 12.6 years) who were diagnosed to have COPD were included into the study. All of the patients underwent left and right heart catheterization. RV contractility was measured according to the method of Ferlinz and LV contractility according to the method of Kennedy and colleagues using indirect digital substraction angiography. Mean pulmonary artery pressures (Mean PPA) and oxygen saturation of the pulmonary artery (SaO2) were measured before and at each stage of graded hypoxic exposure 14%, 12%, and 10% of O2. Right atrial pressures (PRA,syst, PRA,diast, PRA,mean), RV pressures (PRV,syst, PRV,diast, PRV,mean, PRV,end-diast), RV and LV end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume index (SVI), cardiac index (CI), ejection fraction (EF), and heart rate (HR) were calculated before and after breathing a hypoxic mixture of 10% of O2 for 30 minutes. Acute hypoxia induced significant elevation of mean PPA, PRA,syst, PRA,diast, PRA,mean, PRV,syst, PRV,mean, PRV,end-diast, RV EDVI, RV ESVI, LV EDVI, LV ESVI, confidence interval, and HR (p < 0.05). Whereas SaO2 decreased significantly after acute hypoxia (p < 0.05). These findings suggest that the systolic performance of the right and left ventricles were well-maintained during acute hypoxia in patients with COPD.
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PMID:Effects of acute hypoxia on left and right ventricular contractility in chronic obstructive pulmonary disease. 1804 69