Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032463 (polycythemia vera)
 3,374 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Red cell ferritin (rFt) values were measured in 18 patients with iron deficiency anemia (IDA), 7 patients with hereditary spherocytosis (HS), 8 patients with megaloblastic anemia (MA), and 6 patients with polycythemia vera (PV). Furthermore, rFt was analyzed by column isoelectric focusing (IEF). The rFt values (Mean +/- SD) for healthy males and females are 14.3 +/- 10.3 and 7.5 +/- 3.6 ag/cell (ag = 10(-18)g), respectively, and a significant difference was noted between them by Student's t-test (p < 0.01). The mean rFt values in IDA, HS, MA, and PV patients were 1.9, 115.5, 198.3, and 3.3 ag/cell, respectively. The rFt values in IDA and PV patients were significantly lower than normal. However, there was no significant difference between levels presented in the two disease states. The rFt levels in HS and MA were significantly higher than those in healthy subjects. The isoelectric point (pI) of rFt determined by IEF in healthy subjects ranged from 5.1 to 5.7. The pI ranges for IDA patients showed a slight basic shift compared with those of normal subjects, and so did the ranges for PV patients. Marked increase in acidic red cell ferritin was detected by IEF in patients with IDA after iron therapy. The pI ranges for HS patients were diverse, and were considered to depend on the severity or clinical stage of the disease. The rFt of MA patients showed pI ranges similar to healthy subjects and the ranges differed little after Vitamin B12 therapy, irrespective of a drastic decrease in rFt concentration.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Red cell ferritin in non-leukaemic various erythropoietic disorders]. 792 80

A 45-year-old male patient presented with gradual onset of headache, vomiting and blurring of vision of 28 days duration. Ophthalmological examination revealed normal anterior segment and pupillary reflex. No abnormality was detected in the vitreous. Optic disc showed features of advanced papilledema with normal macula and retinal periphery in both eyes. Visual acuity was 20/200 in the right eye and counting fingers close range in the left eye. Non-contrast computed tomography of brain was normal and magnetic resonance imaging showed sagittal sinus thrombosis without any evidence of venous infarction or intracranial mass. Routine hematological investigations revealed increased hemoglobin level, packed cell volume and leucocytosis. Further investigation revealed increased Vitamin B12 and decreased serum erythropoietin. A diagnosis of polycythemia vera was made from the above findings. This case is being presented for the rarity of association of polycythemia vera with bilateral advanced papilledema due to sagittal sinus thrombosis.
 ...
PMID:Polycythemia vera presenting with bilateral papilledema: a rare case report. 1957 11