Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032463 (polycythemia vera)
 3,374 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 56-year-old female nonsmoker presented with episodic hemoptysis, without any other associated respiratory symptoms. Her medical history was notable for polycythemia rubra vera with portal vein thrombosis, which was treated with warfarin, but was complicated by portal hypertension. Esophageal varices were controlled by endoscopic band ligation. Chest radiograph and 64-slice computed tomography scanning failed to identify a culprit lesion. Bronchoscopy identified a vascular structure in the proximal trachea. A contrast-enhanced 320-multidetector row computed tomography scan of the neck showed a tortuous vascular channel in the trachea, which changed in appearance over time, consistent with a tracheal varix. The patient was changed to aspirin therapy and was evaluated by a cardiothoracic surgeon. A conservative approach was adopted, and the patient has had no recurrence of symptoms.
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PMID:Tracheal varix in portal hypertension. 2135 42

Pulmonary vein thrombosis (PVT) is a rarely encountered disease entity with varied clinical presentations. It is usually associated with lung carcinoma, lung surgeries and as a complication of the radiofrequency catheter ablation procedure for atrial fibrillation. Its clinical manifestations can vary from mild hemoptysis to lung infarction with hemodynamic compromise. A 76-year-old male presented with a 2-d history of pleuritic left sided chest pain. His past medical history included polycythemia vera, atrial fibrillation, coronary artery disease, pulmonary embolism and pulmonary hypertension. Chest radiograph was normal, troponins were normal and the 12-lead electrocardiogram did not show any ischemic changes. A computerized tomography pulmonary angiogram revealed a filling defect in the left lower lobe pulmonary vein. He was treated with subcutaneous enoxaparin and his symptoms improved. This case highlights a rare etiology of chest pain and the first reported case of the association of polycythemia vera and pulmonary vein thrombosis. A high index of suspicion is required for appropriate diagnostic work up. PVT can mimic pulmonary embolism. The diagnostic work up and treatment strategies depend on acuity of presentation.
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PMID:Pulmonary vein thrombosis in a patient with polycythemia vera. 2795 55