Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032290 (aspiration pneumonia)
 2,291 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

40 patients presenting for vaginal termination of pregnancy, divided randomly into 4 groups, received either no medication, sodium citrate 30 ml orally, ranitidine 150 mg orally, or ranitidine 50 mg intravenously. During the procedure, gastric contents were removed by orogastric tube for volume and pH measurements. Ranitidine, both orally and intravenously, significantly increased gastric pH and reduced gastric volume. In the control group, only 1 pH was greater than 2.5. Sodium citrate increased the pH above 2.5 in 6 or 10 patients. Fasting patients in the 1st months of pregnancy may be at risk of developing Mendelson's syndrome. Ranitidine is very effective in increasing gastric pH and at the same time reducing gastric volume in such patients.
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PMID:Ranitidine prophylaxis before anaesthesia in early pregnancy. 397 64

Gastroesophageal reflux (GOR) is a major cause of morbidity and failure to thrive particularly in neurologically impaired children. Clinical manifestations of GOR in children range from regurgitation, food refusal, irritability, failure to thrive, hematemesis, wheezing and aspiration pneumonia, apnoea and apparent life threatening events in infants to clinically silent reflux. Although, no one test is always best to diagnose GOR, 24 hour esophageal pH monitoring remains the 'gold standard' for diagnosis. Barium radiography is useful for the diagnosis of associated anatomical abnormalities and endoscopy enables a histological diagnosis of esophagitis. Therapy for gastroesophageal reflux disease is now well established. Proper positioning of the baby and thickening of feeds is beneficial in uncomplicated GOR. Prokinetic agents like cisapride should be tried if dietary management and antacids are ineffective. Metoclopramide or domperidone may be tried in neurologically impaired children. H2-receptor antagonists are indicated in GOR complicated by esophagitis. Ranitidine is regarded to be more potent. Cimetidine has additional spectrum of adverse effects and sufficient information is not available on famotidine. Omeprazole has been shown to be effective in treating GOR-esophagitis resistant to H2 antagonist therapy even in high risk patients.
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PMID:Gastroesophageal reflux in children. 1113 70