Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032290 (aspiration pneumonia)
 2,291 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Drosophila melanogaster females were treated with 1% caffeine, mated with X-rayed males and the frequencies of induced sex-chromosome loss, translocations between the major autosomes and between the Y-chromosome and the major autosomes determined. In a reversal of the results obtained previously with 0.2% caffeine by Mendelson and Sobels, treatment of females with 1% caffeine led to a decrease in sex-chromosome loss, confirming preliminary data of Zimmering and Osgood and an increase in autosome--autosome translocations. It is suggested that the higher concentration of caffeine inhibits replication permitting more time available for chromosome-type restitutions by means of caffeine-insensitive repair mechanisms. In contrast with results for autosome--autosome translocation, the frequency of Y-autosome translocations was depressed below controls suggesting an isolation (by any one of several means) of Y-chromosome breaks from those in the autosomes.
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PMID:Effects of caffeine on maternal repair systems in Drosophila melanogaster. Concentration-dependent reversals of the effects of caffeine on chromosome loss and autosome-autosome translocations induced by x-rays in the paternal genome. 11 76

Theophylline and caffeine are two xanthine-derivated drugs frequently administered for their stimulating effects on the respiratory center in premature babies presenting with "idiopathic apnea". These drugs are known to increase the gastric acid secretion and to decrease the lower esophageal sphincter pressure, that in turn possibly increase gastroesophageal reflux. We studied 14 premature babies presenting with "idiopathic apnea", treated with caffeine at recommended dose (2.5 mg/kg/day). At 24 hour continuous esophageal pH monitoring was performed 3 to 5 days after starting the treatment. In 6 babies total reflux time (5.6% of the investigation time with ph less than 4) and the number of refluxes in 24 hours (15.3) were significantly increased compared to the other 8 babies (pH less than 4: 0.92%; number of refluxes 6.1). These results were also compared to the results obtained ina symptomatic full term neonates (5-10 days old) (pH less than 4: 0.87; number 5.3/24 hours). The results we obtained in the caffeine treated group were independent of the plasma xanthine levels (all within or below therapeutic ranges). A second pH monitoring 2 weeks after stopping caffeine administration was always within normal ranges. The increase of gastroesophageal reflux seems individual for each patient. Gastroesophageal reflux can lead to pulmonary aspiration, and, in this way, it can be the origin of obstructive apnea or aspiration pneumonia.
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PMID:[Xanthines in apnea of premature infants. Influence on gastroesophageal reflux]. 361 72