Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032290 (aspiration pneumonia)
 2,291 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report an autopsy case of a 73 year-old female with idiopathic parkinsonism, characterized pathologically by the wide spread appearance of Lewy bodies (LBs) not only in the pigmented neurons in the midbrain and brainstem but also in the cerebral cortex. Initial symptoms at the age of 62 were finger tremor and gait disturbance, which were followed mainly by mental deterioration, such as regression, dependency, auditory hallucination, depression, emotional incontinence, and a personality change. In the terminal stage, nuchal stiffness in extension, one of the hallmarks of progressive supranuclear palsy, and slow and generalized tremor in all 4 extremities were noted. She died of aspiration pneumonia. The brain was somewhat small and weighed 1100 g after the fixation by formalin. Macroscopical findings included mild cerebral atrophy with mild pial thickening both in the frontal and temporal lobes and slight expansion of the ventricular system. Histopathologically, severe loss of neuronal cells in both the pallidum and Luy's body and moderate loss of large cells in the putamen were noted in addition to the typical findings of Parkinson's disease in the substantia nigra and locus caeruleus including neuronal cell loss, depigmentation, and gliosis. These findings in the basal ganglia were more conspicuous than the two controls of classical Parkinson's disease. The distribution, stainability in the routine methods of staining, and shape of Lewy bodies in the cerebral cortex conformed to those of previous reports. The similar case reports in the literatures do not seem to have paid much attention to the findings of the basal ganglia observed in our case.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[An autopsy case of idiopathic parkinsonism with numerous Lewy bodies in the cerebral cortex--diffuse Lewy body disease]. 165 48

We report a 59-year-old woman with generalized amyotrophy and dementia. She showed personality change at 53 years of age. When she was 56 years old, she began to show abnormal and violent behaviors. At age 58, she developed dysphagia and amyotrophy of upper limbs. She was admitted to a hospital for the treatment of aspiration pneumonia. She was severely demented and showed pseudobulbar palsy, amyotrophy of tongues, weakness of upper limbs, and pyramidal signs. She was still able to walk by herself. Dementia, pseudobulbar palsy, and amyotrophy progressed rapidly. At age 59, she became bed ridden and required tube feeding. She died by aspiration pneumonia at age 59. The patient was discussed at a neurological CPC and the chief discussant arrived at the conclusion that the patient had ALS dementia. Other possibility discussed was Pick's disease with amyotrophy. Post-mortem examination revealed severe lower motor neuron degeneration. The upper motor neurons were unaffected. Neuronal loss was not observed in the cerebral cortex, but moderate gliosis was seen in the cerebral white matter. In addition, the substantia nigra was moderately degenerated. There were ubiquitin positive neuronal inclusions in the granular cells of the dentate gyrus. Also, Bunina bodies were seen in the neurons of spinal anterior horns. These findings were characteristic pathology for ALS with dementia.
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PMID:[A 59-year-old woman with personality change and abnormal behavior followed by amyotrophy and dementia]. 1624 71

We here report an autopsy case of meningovascular neurosyphilis associated with Fischer's plaques, a demyelinating lesion which is typical of the late stage general paresis. A Japanese male who was 59 years old at the time of death, developed personality change and dementia. He was clinically diagnosed as having neurosyphilis by serological tests of the blood and the cerebrospinal fluid. Despite the administration of Penicillin, psychiatric symptoms were unchanged and the patient died of aspiration pneumonia after the clinical course of 18 month. The weight of brain was 1485 g. Postmortem pathological examination of the brain revealed extensive leukocyte infiltration into the meninges, in particular, around the meningeal vessels. Perivascular leukocyte infiltration, though less severe, was also noted in the brain parenchyma in the temporal and frontal cortices. Brain atrophy and neuronal cell loss were absent. The primary pathology of this case was, thus, considered to be meningeal and vascular inflammation consistent with the stage III meningovascular neurosyphilis. However, we also found in the frontal and parietal cortices a few small demyelinating lesions, which were referred to as Fischer's plaques. Fischer's plaque is a hallmark of advanced stage of general paresis where the principal lesion exists in the brain parenchyma. We speculate that, in patients with chronic progressive neurosyphilis, meningovascular and parenchymal lesions coexist during the transitional stage. Attention has to be paid for the occurrence of atypical neurosyphilis in association with increased immuologically compromised hosts and frequent usage of antibiotics.
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PMID:[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. 1766 52