Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0032285 (
pneumonia
)
54,520
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Jam-C(-/-) mice exhibit growth retardation and multilobular
pneumonia
concomitant with poor survival of the mice under conventional housing conditions. The deficient mice present a mega-oesophagus and have altered airway responsiveness. In addition, the number of circulating granulocytes is increased in Jam-C(-/-) mice as compared to control animals. These phenotypes probably reflect the different functions of
JAM-C
expressed by endothelial and mesenchymal cells. Indeed, the deregulation in the number of circulating granulocytes is caused by the lack of
JAM-C
expression on endothelial cells since rescuing endothelial expression of the protein in the Jam-C(-/-) mice is sufficient to restore homeostasis. More importantly, the rescue of vascular
JAM-C
expression is accompanied by better survival of deficient mice, suggesting that endothelial expression of
JAM-C
is mandatory for animal survival from opportunistic infections and fatal
pneumonia
.
...
PMID:Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice. 1745 69
