Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Virological, serological and immunofluorescence studies revealed circulation of rhinoviruses of the strains 1A, 1B, 2, 3, 7, 9, 10, 12, 13, 14, 16-23, 27, 29-33, 42, 48, 53, 56, 60 and 69 on the territory of Czechoslovakia and the Soviet Union. According to virological results, type 48 predominated and was followed in frequency of occurrence by types 27, 14 and 16 in the USSR and 30, 1A and 31 in the CSSR. RV infection in adults with ARD diseases was the aetiology in 28.5% of cases. Among the causative agents of acute rhinitis, rhinosinusitis and otitis, rhinovirus infection makes up a large proportion. Interrelation has been found between rhinovirus infection and chronic inflammation of the mucosa of the nose, the accessory sinuses and the ears. Prolonged course of rhinovirus infection and isolation of the virus in the late stages of disease (1-4 months after its onset) support the presumption that rhinoviruses promote chronicity of inflammation. RV was isolated from patients with chronic pneumonia from the lower respiratory passages (bronchial secretion). Rhinoviraemia was found in a child who died of ARD.
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PMID:The spread of rhinoviruses in the Soviet Union (USSR) and in Czechoslovakia (CSSR) and the role of their pathology. 23 23

The human herpesvirus-6 (HHV-6) causes exanthema subitum ("e.s."). "E.s." is characterized by fever, exanthem (rash), in many cases gastroenteritis, occasionally cerebral convulsions (but more frequently general cerebral irritability) and enlargement of all lymph nodes; usually there are mild catarrhal respiratory symptoms of the upper airways (ARD). So-called "complications" of an ARD (pneumonia, acute purulent otitis media, acute sinusitis) due to bacterial infections are very unusual as sequelae of a HHV-6 infection. Here we report the case of 2 small children (toddlers) suffering from bronchopneumonia or pneumonia and acute sinusitis maxillaris associated with an acute HHV-6 infection. It seems that HHV-6 (like other respiratory tract viral pathogens) also can lead to secondary bacterial infections of the lower respiratory tract. So far it is not known, why such complications are so rare, although the extreme granulocytopenia accompanying "e.s." suggests a transient disturbance of the antibacterial defence mechanisms.
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PMID:[Complications of acute respiratory tract infection (pneumonia, sinusitis) in young children associated with acute HHV 6 infection]. 132 58

The human herpes virus 6 (HHV 6) may induce not only the wellknown condition of exanthem subitum, but also a number of more common (cf. Part 1) or rare, even previously unknown, clinical manifestations. Part 2 of this paper deals with the more rarely observed manifestations. These include complications of ARD (sinusitis, otitis media, bronchial pneumonia) hepatitis, encephalitis or Pfeiffer's disease (mononucleosis-like syndrome). In individuals with a relevant disposition (genetic HLA/DR type?) initiation or (re-)activation of rheumatoid arthritis (JCA = juvenile chronic arthritis) or chronic iridocyclitis may occur. Although, on account of the high prevalence of vaccination in our population (approximately 95%), prenatal infections are extremely rare, they may manifest in a severe "septic" form (fatalities have occurred) or may lead to neurological deficits (comparable with cytomegalovirus infection). To date, no specific therapy (e.g. gammaglobulin, virostatics) or reliable preventive measures (e.g. vaccination) are available.
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PMID:[Infections with herpesvirus 6--really only "exanthema subitum"? Part 2: Rare or unknown disease pictures]. 133 53

The rates of mortality due to influenza, acute respiratory disease and acute pneumonia were studied in relation to the patients' age, sex, epidemic etiology. Quantitative characteristics of excess mortality might be used in the assessment of the influenza epidemic intensity. The most vulnerable groups of the population were identified in whom a comprehensive complex of measures should be made to reduce ARD mortality rates.
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PMID:[Mortality rate of influenza, acute respiratory diseases and acute pneumonia as a health status factor]. 753 95

The existence of catharreal respiratory symptoms (such as pharyngitis, tracheitis, bronchitis etc.) is established as the usual manifestation of "exanthema subitum" due to acute human herpesvirus-6 (HHV-6) infection. But so far pneumonia, purulent sinusitis, purulent otitis media and/or acute obstructive bronchitis (bronchiolitis) in infants and children have not been described. Here we report the results of observations of 2 children with bronchopneumonia/sinusitis maxillaris and severe bronchiolitis associated with an acute HHV-6 infection. Other respiratory viruses were excluded as agents causing the ARD.
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PMID:Acute obstructive respiratory diseases (ARD) and bacterial complications of ARD (pneumonia, sinusitis) in infants and children associated with human herpesvirus-6 infection. 825 11

The article presents the analysis of causes and outcomes of ARD and pneumonia incidence among the servicemen in one of the military units during the period 2002-2003. 95 forensic medical examinations were analyzed. The terms of disease occurrence, complications, unfavorable outcomes are presented. The defects in medical care rendering are shown. The recommendations on prophylaxis of such cases are shown.
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PMID:[Medicolegal analysis of ARD mass cases occurred in servicemen]. 1586 60

Acute diseases of respiratory organs occupy leading position among all diseases in army. In 2009 a part of total morbidity of ARD, flu, pneumonia and acute bronchitis was 45.7% from all diseases. With the start of the usage of pneumococcal vaccine in the army continuous increase of morbidity of pneumonia gave way to reduction. In postvaccinal period in patients with pneumonia, frequency of pneumococcus's effuse reduced under the increase of frequency of detection of viruses, staphylococcus and streptococcus. Considering polyaetiology of pneumonia and ARD, significancy of immune inefficiency in its developments, it is necessary to use specific prophylactic drugs with antiviral products in period of reinforce.
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PMID:[Epidemiology and development of prophylaxis of acute respiratory diseases and pneumonias in servicemen in modern conditions]. 2125 84