Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Changing bacterial diseases in the general population of which HIV practitioners should be aware include: new staphylococcal syndromes caused by community-acquired methicillin-resistant Staphylococcus aureus USA300 strains (eg, necrotizing skin infections, pneumonia, fasciitis); continued high rates of community-acquired pneumonia in the potent antiretroviral therapy era; increase rates and severity of Clostridium difficile-associated disease due to the fluoroquinolone-resistant NAP1 strain, and the new scare from extensively drug-resistant tuberculosis, primarily as a potential threat to health care in Africa. This article summarizes a presentation on important bacterial infections made by John G. Bartlett, MD, at the International AIDS Society-USA course in New York in March 2007.
 ...
PMID:Changing trends in bacterial infections: Staphylococcus aureus, bacterial pneumonia, Clostridium difficile. 1759 28

Clostridium difficile (C. difficile) is a common causative agent of pseudomembranous colitis (PMC). C. difficile-associated diarrhea (CDAD) ranges from mild diarrhea to life threatening PMC. Recently, a highly virulent strain of C. difficile polymerase chain reaction ribotype 027 was found in North America, Europe, and Japan. A 52-yr-old woman with anti-tuberculosis medication and neurogenic bladder due to traffic accident experienced five episodes of C. difficile PMC after taking antibiotics for pneumonia along with septic shock and acute renal failure. She was readmitted to the intensive care unit and treated with oral vancomycin with refractory of oral metronidazole, inotropics and probiotics for over 60 days. C. difficile isolated both at the first and the last admission was identified as C. difficile ribotype 027 by ribotyping, toxinotyping, and tcdC gene sequencing, which turned out the same pathogen as the epidemic hypervirulent B1/NAP1 strain. This is the first case of C. difficile PCR ribotype 027 in Korea. After discharge, she was maintained on probiotics and rifaximin for 3 weeks. She had no relapse for 6 months.
 ...
PMID:The first case of antibiotic-associated colitis by Clostridium difficile PCR ribotype 027 in Korea. 1954 21