Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0032285 (
pneumonia
)
54,520
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-11
(
IL-11
) is an interleukin-6 (IL-6) family cytokine shown to play a protective role in acute inflammatory settings including systemic infection. In this study we addressed the role of
IL-11
in acute bacterial pneumonia using a mouse model of E. coli
pneumonia
. Compared with other related cytokines,
IL-11
protein was maintained at high levels in the lung at baseline, with only mild alterations in whole lung and BALF levels during acute infection. The primary source of
IL-11
in the lung was the epithelium, but steady state production was not dependent on the inflammatory transcription factor nuclear factor kappa B in cells of either myeloid or epithelial lineage. Blockade of
IL-11
with neutralizing antibodies resulted in a mild but significant decrease in neutrophil recruitment and increase in pulmonary edema during
pneumonia
, without detectable alterations in bacterial clearance. Exogenous
IL-11
administration, however, had no effect at baseline or during infection. Overall, we conclude that maintenance of lung
IL-11
concentrations may influence acute pulmonary inflammation during infection, albeit modestly.
...
PMID:Roles of interleukin-11 during acute bacterial pneumonia. 3141 18
