Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum interleukin-2 (IL-2) levels were examined in the serum of 17 lung transplant recipients who underwent transbronchial biopsies to diagnose reasons for allograft dysfunction. Over 60 transbronchial biopsies were performed in these 17 patients in a 22-month observation period. Mean serum IL-2 levels were significantly elevated in patients experiencing allograft rejection (p less than 0.01), cytomegalovirus pneumonia (p less than 0.0006), and bacterial/fungal pneumonia (p less than 0.01), when compared with those with normal or nondiagnostic findings on transbronchial biopsies. Serum IL-2 levels were not extraordinarily elevated as seen in other types of allograft rejection and did not differentiate between infection and rejection. In addition, overlapping values were seen in the patient groups tested. Despite these limitations, elevated serum IL-2 levels in lung allograft recipients may provide supplemental information helpful in deciding when to perform transbronchial biopsies.
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PMID:Serum interleukin-2 levels in lung transplant recipients: correlation with findings on transbronchial biopsy. 132 58

To determine cell-mediated immune mechanisms involved in the resolution of chlamydial genital infection of mice, we utilized an established murine model in which it has been demonstrated that resolution of infection occurs independently of the antibody response. Splenic T lymphocytes were obtained from mice that had previously been immunized with viable elementary bodies of the mouse pneumonitis agent (MoPn), a Chlamydia trachomatis biovar. Antigen-reactive T lymphocytes were maintained and expanded in vitro by frequent restimulation with UV light-inactivated MoPn in the presence of antigen-presenting cells and recombinant interleukin-2 (rIL-2). Flow cytometry indicated that this cell line was at least 92% positive for the pan-specific T-cell marker Thy1.2. Stimulation of the cells in the presence of syngeneic antigen-presenting cells plus MoPn antigen and in the absence of exogenous IL-2 induced the cells to produce IL-2 activity in culture supernatants. Following adoptive transfer, this T-lymphocyte line was effective in inducing resolution of an ongoing MoPn genital infection in congenitally athymic nude mice which otherwise maintain chronic unresolved infections. The line was less efficient in resolving the infection after longer periods in culture. An additional T-lymphocyte line was derived from the spleens of athymic mice that had received the first line and had resolved the infection. These T cells were also capable of inducing resolution of the infection. Lastly, this cell line was treated with specific antibody and complement to delete either CD4+ or CD8+ T lymphocytes in an attempt to enrich for T-cell subpopulations prior to transfer into infected athymic mice. The anti-CD4-treated line was essentially depleted of CD4 cells, while the anti-CD8-treated line was only partially enriched for CD4 cells, with a large proportion of CD8 cells still present. Nude mice that received either of the treated T-cell lines or the parental cell line were capable of resolving the infection, although the line with increased numbers of CD4 cells was more efficient than either the parental line or the CD8 line.
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PMID:Resolution of chlamydial genital infection with antigen-specific T-lymphocyte lines. 170 44

Recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) was administered to a patient with multiple myeloma (IgA, stage IIA) who had a chemotherapy-induced bone marrow aplasia with granulocytopenia complicated by severe pneumonia and septicemia. The rhGM-CSF was given as i.v. infusions, 300-400 micrograms daily, for three weeks. The patient responded both hematologically and clinically with improved granulocyte counts and clearance of massive pulmonary infiltrates. We also observed a partial remission of the myeloma with decreasing s-IgA levels and reduced plasma cell infiltration of the bone marrow during a period of up to four months after the rhGM-CSF treatment. Immunological studies performed during and after cytokine administration showed an increase in serum interleukin-2 (IL-2) levels and HLA-DR positive T-lymphocytes indicating an activation of the immune system. It is suggested that rhGM-CSF induced immunological changes which may have contributed to the partial regression of the myeloma.
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PMID:Increase of serum interleukin-2 and regression of myeloma after rhGM-CSF treatment of drug induced bone marrow aplasia. 193 5

The content of interleukins-1 and -2 in the peripheral blood was studied in 60 patients with different variants of acute pneumonia. The initial period of acute pneumonia was distinguished by an increased level of interleukin-1 and reduction of interleukin-2 level. The most characteristic prognostic sign of complicated course of acute pneumonia in this period was the high level of reduction of interleukin-2. It is recommended to use the obtained results for clinical prediction of unfavourable course of acute pneumonia and instituting differentiated pathogenetic treatment.
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PMID:[The dynamic interleukin-1 and -2 contents in different variants of the complicated course of acute pneumonia]. 206 65

The lung has an array of immunological defenses to protect itself against potentially invasive microorganisms, which include the immunoglobulin-rich alveolar lining fluid, alveolar macrophages, T lymphocytes, and polymorphonuclear neutrophils. Immunosenescence is a major predisposing factor to the increased incidence, morbidity, and mortality of pneumonia in the elderly. The progressive involution of the thymus gland in humans plays a pivotal role in the development of the immunodeficiency state characteristic of the older individual. Age takes its greatest toll on the cell-mediated arm of the immune system. Aged T cells are impaired in their ability to activate and proliferate in response to an antigen. This is partly due to age-associated structural and functional changes within the T cell. In addition, the ability of the T cell to secrete interleukin-2 (a cytokine necessary for the recruitment of other T cells) declines with age. The impaired antibody response of the elderly to foreign antigens, including the pneumococcal polysaccharide and the influenza vaccine, appears to be secondary to a deficiency of T helper cells. The macrophage functions well even in old age, but the recruitment of macrophages by senescent T cells is diminished. There also may be a blunted inflammatory response in the older individual secondary to impaired polymorphonuclear neutrophils chemotaxis and phagocytosis.
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PMID:Altered immune status in the elderly. 209 70

Eighteen recipients of allogeneic T cell-depleted bone marrow who developed 22 episodes of interstitial pneumonitis were investigated by bronchoalveolar lavage for the cause of pneumonitis. The cells obtained were examined using a panel of monoclonal antibodies with immunocytochemical techniques to identify lymphocyte subsets and the presence of surface molecules indicative of lymphocyte activation. The majority of patients had an excess of lymphocytes in lavage and most of these cells were positively stained with the McAb recognizing the CD8 antigen (suppressor/cytotoxic type T cells). Although the proportions of CD4+ (helper type) T cells were below normal, the absolute numbers were within normal limits, thus the CD4:CD8 ratio was consistently 1:1 or less. A large proportion of the CD8+ cells displayed HLA-DR molecules (RFDR1+), interleukin-2 (IL-2) receptors (CD25+) and high concentration of CD7 antigen (RFT2+). Further analysis revealed that most CD8+ cells were CD5+ (RFT1+) yet a large proportion (20-40%) were CD5-. A majority of CD8+ cells was also CD38+ (RFT10+) and Leu7+. No clear correlation between the emergence of a raised proportion of activated CD8+ cells and diagnosed cytomegalovirus infection was found. These results demonstrate, however, that cells with the phenotype of the resident T cells of the bronchial epithelium (CD8+CD5-) emerge to the air spaces and express activation markers. This raises the intriguing paradox of an aggressive local immune response occurring in an otherwise immunosuppressed group of patients.
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PMID:Pneumonitis in bone marrow transplant recipients results from a local immune response. 220 68

We constructed transgenic mice that carry the cDNA of human interleukin-2 (IL-2) under the control of the H-2Kd promoter. The IL-2 transgenic mice expressed human IL-2 mRNA in the thymus, spleen, bone marrow, lung, muscle and skin. Human IL-2 protein was also detected in their sera. The IL-2 transgenic mice suffered from alopecia and pneumonia, but no typical autoimmune reactions seemed to be involved in these lesions. In the epidermis of the IL-2 transgenic mice there was an increase in Thy-1+ dendritic epidermal cells (DEC), which might be involved in the skin lesion. Immune responses of their spleen cells against antigens were significantly impaired whereas their spleen cells responded well to polyclonal lymphocyte activators.
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PMID:Effects of the deregulated expression of human interleukin-2 in transgenic mice. 248 82

The temporal relation between a lung infection with bovine herpesvirus-1, suppression of some immune functions, and susceptibility to secondary bacterial infection resulting in fibrinous pneumonia prompted a study to determine the mechanism(s) involved in the apparent immunosuppression. In six independent experiments employing from five to 40 calves, we studied the immunologic parameters of migration of and superoxide anion production by polymorphonuclear neutrophils, lectin-induced lymphocyte proliferation, interleukin-2 production, natural cytotoxicity, interferon and antibody formation, as well as complement activation and hematologic parameters. Chemotaxis of polymorphonuclear neutrophils, natural cytotoxicity, and mitogen response of peripheral blood leukocytes were depressed, whereas superoxide anion generation by polymorphonuclear neutrophils was transiently increased and interleukin-2 production was only marginally affected. The assumption that virus-induced interferon might be a common cause for the various changes could not be substantiated. However, the results did suggest that mechanisms other than lack of T helper cell activity, accessory cell activity of macrophages, or development of suppressor T cells were the cause of suppressed mitogen responses. None of the immunologic parameters appeared to have consistent prognostic value with respect to outcome of the infection.
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PMID:Viral-bacterial pneumonia in calves: effect of bovine herpesvirus-1 on immunologic functions. 258 Sep 16

We constructed two strains of transgenic mice that carry the cDNA of either human interleukin-2 (IL-2) or the L chain of its receptor under the control of the H-2Kd promoter. The IL-2 transgenic mice expressed human IL-2 mRNA in the thymus, spleen, bone marrow, lung, muscle, and skin. Human IL-2 protein was also detected in their sera. The IL-2 transgenic mice suffered from dermatitis and pneumonia. Immune responses of their spleen cells against antigens were significantly impaired whereas their spleen cells responded well to polyclonal lymphocyte activators, suggesting that constitutive expression of IL-2 might have affected the repertoire formation of T cells in the mice. The IL-2 receptor (IL-2R) transgenic mice were healthy. We crossed the IL-2 and IL-2R transgenic mice to yield hybrid mice expressing both the ligand and the receptor constitutively. The life span of the hybrid mice was remarkably shortened. In addition to several abnormalities found in the IL-2 transgenic mice, spleen cells of the hybrid mice showed the strong natural killer activity which was ascribed to a large number (18%) of Thy-1+/CD3-cells unique to their spleen.
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PMID:Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice. 298 Oct 23

Increased levels of soluble interleukin-2 (IL-2) receptor were found in plasma of six patients after the heart transplantation. The levels peaked the first week after transplantation and then gradually decreased to normal levels. The moderate episodes of heart transplant rejection did not affect the IL-2 receptor levels in comparison to transplant recipients without the rejection episodes. However, the transplant patients with pneumonia had the IL-2 receptor levels ten times higher than healthy controls. Hence, the IL-2 receptor levels in plasma might be a valuable indicator of the dynamics of the acute infection in heart transplant recipients.
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PMID:Interleukin-2 receptor levels are increased in blood of heart transplant patients during infections. 312 88


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