Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy and safety of cefadroxil in the treatment of paediatric patients with a wide variety of infections were evaluated in a multicentre clinical trial. This study included 395 infants and children with Group A streptococcal pharyngitis, sinusitis, otitis media, bronchitis, pneumonia or bronchopneumonia, urinary tract infections and acute gastroenteritis. Cefadroxil was given as a suspension in a daily dose of 30 to 50 mg/kg in 2 divided doses every 12 hours to all but 76 patients; 50 patients with acute otitis media were given 100 mg/kg/day in 2 doses and 26 patients with urinary tract infections received 25 mg/day once daily. Of 317 patients with respiratory tract infections and 78 with urinary or gastrointestinal infections, 95 and 100%, respectively, were clinically cured following treatment with cefadroxil.
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PMID:Cefadroxil in the treatment of susceptible infections in infants and children. 380 50

Laboratory and clinical investigations were performed on cefadroxil, and the results were obtained as follows. (1) Sensitivity distribution of cefadroxil. In S. aureus, two peaks were observed with inoculum size of 10(8)/ml: 1.56-3.13 microgram/ml and 12.5-25 microgram/ml, while with inoculum size of 10(8)/ml, the distribution was in the range of smaller than or equal to 0.1-25 microgram/ml, and the sensitivity peak was 0.78-1.56 microgram/ml. In S. pyogenes, with inoculum size of 10(8)/ml, sensitivity distribution was in the range of 0.05-1.56 microgram/ml, and the peak was 0.05 microgram/ml. On the other hand, with inoculum size of 10(6)/ml, distribution was 0.0006-1.56 microgram/ml, and the peak was 0.0006-0.012 microgram/ml, thus sensitivity of cefadroxil being 2 tubes higher. In E. coli, with inoculum size of 10(8)/ml, strains showed mostly high resistance as more than 100 microgram/ml, whereas with inoculum size of 10(6)/ml sensitivity was distributed between 3.13-50 microgram/ml, and the peak was 12.5-25 microgram/ml. (2) Absorption and excretion of cefadroxil: A dose of cefadroxil 5 mg/kg, 10 mg/kg or 20 mg/kg was administered to 9 cases of children aged from 4 years and 6 months to 11 years and 9 months, and serum levels of the drug were measured. As the results, in the group of 5 mg/kg dosing, the value was 0.94 microgram/ml at 30 minutes, 3.55 microgram/ml at 60 minutes, 7.65 microgram/ml at 2 hours, 2.55 microgram/ml at 4 hours, and 1.09 microgram/ml at 6 hours. In the group of 10 microgram/ml dosing, value of the drug was 4.18 microgram/ml at 30 minutes, 10.70 microgram/ml at 1 hour, 12.75 microgram/ml at 2 hours, 8.05 microgram/ml at 4 hours, and 2.33 microgram/ml at 6 hours. In the group of 20 mg/kg dosing, value was 9.93 microgram/ml at 30 minutes, 18.43 microgram/ml at 1 hour, 24.70 microgram/ml at 2 hours, 15.50 microgram/ml at 4 hours, and 6.45 microgram/ml at 6 hours. Dose response was observed thus distinctly among 3 groups. Recovery ratio of cefadroxil in urine was 76.14% within 6 hours. (3) Clinical trial with cefadroxil: Cefadroxil was applied clinically in 80 cases (76 patients). These included 22 cases of lacunar tonsillitis, 13 cases of pharyngitis, 24 cases of bronchitis, 6 cases of pneumonia, 8 cass of urinary tract infection, 5 cases of hemolytic streptococcal infection, 1 case of cellulitis, and 1 case of otitis media. Efficacy was obtained in 72 cases out of 80 cases ratio being thus 90%. Change of organisms was proven in 35 cases, among which disappearance and reduction of organism were observed in 32 cases (91.45). No adverse reaction was noticed throughout all cases. No abnormal value was recognized in laboratory findings.
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PMID:[Laboratory and clinical studies on cefadroxil in the field of pediatrics (author's transl)]. 724 7

Cefadroxil, a cephalosporin, had been prescribed to children with superinfected atopic dermatitis, and was shown to improve both the infection, the clinical status and induced a dramatic lowering of the serum total IgE levels. Further studies have confirmed the IgE immunomodulating properties of cefadroxil. We report the case of a 3 year old asthmatic child who was hospitalized for superimposed pneumonia and was included in a study evaluating cefadroxil. The child was also suffering of juvenile rheumatoid arthritis. After treatment with cefadroxil and oral salbutamol, the child fully recovered. The initially elevated serum IgE (day 1:556 IU/ml) dropped to normal values (day 21: 52 IU/ml), while the production of IgE in vitro by peripheral blood B cells was normalized. We suggest that one mechanism of action of cefadroxil is the stimulation of production of gamma interferon in patients with atopic disorders; this mechanism interferes with the IL-4 primary signal, as well as with other second signals recognized for the synthesis of IgE. Gamma interferon may also prove beneficial for the control of juvenile rheumatoid arthritis.
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PMID:Cefadroxil reduces the production of IgE in a 3 year old asthmatic with juvenile rheumatoid arthritis. 823 16