Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Complex treatment with ceftriaxone (or ceftazidime) and intravenous immunoglobulin G (Biaven V. I.) was performed at 21 patients with severe pneumonia and tracheobronchitis complicated by immunedeficient status (myasthenia, diabetes mellitus etc). The results of the treatment proves strong tendency to normalization of the immune system (ceruloplasmin level, CIC, catalase, immunoglobulins) along with clinical signs regression.
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PMID:[Current possibilities and perspectives of the combined treatment of patients with severe bronchopulmonary diseases]. 1251 92

To determine the significance of results of dynamic study of C-reactive protein (C-RP) and ceruloplasmin (CP) concentrations in plasma for evaluation of adequacy of community-acquired pneumonia (CAP) launching antibacterial chemotherapy we investigated 97 patients (servicemen on draft). C-RP and CP were determined by immunoturbidimetric method. The blood samples were obtained on admission, on the 3rd-4th day of treatment and on the 7th-8th day of stay in the hospital. The transformations of pulmonary infiltrates were evaluated at the same periods with the use of digital chest fluorography. The strong correlation between transformations of pulmonary infiltrates for serum C-RP level (r=0.79) and CP level (r=0.71) was observed. The dynamic assessment of C-RP and CP levels is a simple and reliable test that permits to use it as an adjunctive procedure in C-RP diagnosis and evaluation of treatment effectiveness. The serum CRP level more than 110 mg/l and CP level higher than 6.3 mg/l should be considered as diagnostic and prognostic markers of severe CAP.
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PMID:[The role of humoral markers of inflammation activity in the evaluation of adequacy of antibacterial chemotherapy for community-acquired pneumonia]. 1575 66

In this article, oxidative stress and enzymic-non-enzymic antioxidants status were investigated in children with acute pneumonia. Our study included 28 children with acute pneumonia and 29 control subjects. The age ranged from 2 to 11 years (4.57+/-2.13 years) and 2 to 12 years (4.89+/-2.22 years) in the study and control groups, respectively. Whole blood malondialdehyde (MDA) and reduced glutathione (GSH), serum beta-carotene, retinol, vitamin C, vitamin E, catalase (CAT), ceruloplasmin (CLP), total bilirubin, erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels were studied in all subjects. There was a statistically significant difference between the groups for all parameters except for serum CAT. Whole blood MDA, serum CLP and total bilirubin levels were higher in the study group than those of the control group. However, SOD, GPx, beta-carotene, retinol, vitamin C, vitamin E and GSH levels were lower in the study group compared with the control group. All antioxidant vitamin activities were decreased in children with acute pneumonia. Our study demonstrated that oxidative stress was increased whereas enzymic and non-enzymic antioxidant activities were significantly decreased in children with acute pneumonia.
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PMID:Oxidative stress and enzymic-non-enzymic antioxidant responses in children with acute pneumonia. 1663 91

The blood prooxidant and antioxidant systems were studied in 165 patients with pneumonia of bacterial and viral etiologies over time. There was a regular and significant increase in the levels of malondialdehyde, spontaneous nitroblue tetrasolium test, and catalase in the red blood cells; in parallel to this, there was ceruloplasmin activity suppression that depended on etiology, stage, and severity. Much pronounced and long-term impairments of the activity and level of prooxidant and antioxidant indices were suggestive of a severer clinical course and the presence of complications and concomitant diseases of infectious and inflammatory nature.
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PMID:[Lipid peroxidation in pneumonia of bacterial and viral etiologies]. 2003 Feb 64

A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease (AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease (WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests.
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PMID:Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report. 2937 14


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