Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From 1972 to 1977, 162 patients were treated with definitive radiotherapy for the underlying unresectable non-small-cell bronchogenic carcinoma by a radiotherapeutic technique that had sequentially evolved from a low-dose (40-45 gray) small-volume approach (AP-PA POP) to a high-dose (60-64 gray) large-volume en-bloc approach (AP-PA POP plus AP-RPO-LPO) which included the primary tumor and the entire regional lymphatics including both supraclavicular areas. Median survival and short-term survival up to 1.5 years were independent of radiation doses (40-64 gray) and target volumes studies. However, long-term survival greater than or equal to 2 years was radiation-dose and target-volume dependent: actuarial survival 36% and 28% vs. 10% and 3% for the high-dose (60-64 gray) en-bloc approach vs. low-dose (40-45 gray) small-volume radiotherapy at 2 and 3 years, respectively, with a minimum follow-up of 2 years, P less than 0.05. Actuarial five-year survival rate 7.5% was obtained with radiation dose greater than or equal to 50 gray. However, there was no five-year survivor among patients who were treated with radiation dose less than 50 gray. Local tumor control is radiation-dose dependent: local tumor control rates at greater than or equal to 18 months were 76% vs. 29% by 56-64 gray vs. 40-49 gray, respectively, P less than 0.05. The patterns of failure appeared to be tumor-histology dependent; for squamous cell carcinoma, the primary and regional lymphatic areas are the most common sites of failure, and for adenocarcinoma, it is the brain or bone. The high-dose en-bloc radiotherapy has been very well tolerated; 5% (4/80) incidence of symptomatic pneumonitis has been observed.
 ...
PMID:Improved survival of patients with unresectable non-small-cell bronchogenic carcinoma by an innovated high-dose en-bloc radiotherapeutic approach. 626 49

The preventive and therapeutic effect of the traditional Chinese compound medicine Feixiankang (FXK) on the mice pulmonary fibrosis formation have been studied with the mice model. The level of LPO and the activity of SOD in the mice lung showed that LPO increased remarkably (P < 0.01), while the activity of SOD decreased significantly (P < 0.01) during the alveolar pneumonia period, although the LPO content had no significant change (P < 0.01) during experimental pulmonary fibrosis formation. In addition, the effect of FXK on the reducing of LPO was much stronger than that of the antioxidative agent Vitamin E. Also, FXK could improve the activity of SOD.
 ...
PMID:[Effect of promoting blood circulation to remove stasis and supplementing qi and nourishing yin on the lipid peroxide and superoxide dismutase during experimental pulmonary fibrosis]. 753 99

The changes in the levels of diene conjugates, Schiff bases and malonic dialdehyde were followed up in red blood cells and plasma of 178 acute pneumonia (AP), diabetes mellitus (DM) and AP+DM patients. The findings for AP and AP+DM were compared to acute-phase indices of the inflammation and clinical pattern. The blood of the patients was endovascularly exposed to low-energy He-Ne laser irradiation. The resultant trends in LPO were recorded. It is concluded that by changes in the concentrations of diene conjugates, Schiff bases and malonic dialdehyde one can judge on the course of the above diseases and evaluate efficacy of on-going treatments, eg. He-Ne laser, antioxidants.
 ...
PMID:[The characteristics of the regulation of blood lipid peroxidation in acute pneumonia and acute pneumonia combined with diabetes mellitus]. 805 77

Study involved 52 women (mean age 43+/-1,3) without any evidence of CHD, suffering from dull or acute prolonged non-anginal chest pain, with undergoing chronic bacterial-viral infection--Chlamydia pneumonia in combination with HSV-I, CMV and/or EBV. 30--patients serum-positive to plasma markers (IgG antibodies) of previous infection were enclosed in group I, 22--with plasma consumption of IgA+IgG antibody complex demonstrating re-infection/reactivation phase of disease--in group II and 20 healthy serum-negative females (median age 47+/-2,8 years)--controls (group III). The intergroup analysis revealed the complex of disturbances in some plasma parameters of II group patients, namely significant elevation of CRP, F and LPO activity vs. I and III group data, along with reduced parameters of immune status in both groups of infected persons. The patients with mixed infections showed the high frequency of specific re-polarization phase abnormalities, cardiac rhythm and conduction disturbances. These changes together with intimate-medial wall injuries of inflammatory origin disclosed by DS technique enables us to suggest that in women with previous chronic untreated or insufficiently treated infection, in cases of their overload activity, recurrent or super-infection may provide deep immunosuppressive conditions leading to farther cardio-vascular abnormalities.
 ...
PMID:Chronic bacterial-viral vasculitis as manifestation of systemic inflammatory response syndrome in females. 1623 91