Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although increasing attention is being given to Legionella pneumonia in Japan, reports of solitary onset of this disease are scant in Japan. The patient, from whom L. dumoffii was isolated, was a 59-year-old male with no underlying disease. He visited our hospital because of fever and cough, and was admitted to our department for X-ray findings consistent with pneumonia. After admission, pulmonary lesions spread rapidly, and based on the suspicion of Legionella pneumonia, drugs such as EM, RFP and MINO were used. However, the patient died on the 26th hospital day. L. dumoffii was isolated from specimens obtained by airway aspiration before death and specimens of lung abscess and airway discharge obtained during autopsy (7 specimens in total). In addition, the L. dumoffii antibody titer in the serum became elevated. This is the first case of L. dumoffii pneumonia reported in Japan. The other case was in an 81-year-old male with underlying disease. He was admitted urgently with suspected pneumonia but died on the following day. L. pneumophila serogroup 5 was isolated from autopsied lung tissue. Fatality is high for this disease, making early diagnosis and treatment with appropriate antibiotics essential. Physicians should bear in mind the possibility of this disease and request the necessary laboratory tests in suspected cases without delay.
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PMID:[Legionellosis]. 227 66

We treated three patients of chlamydial pneumonia with OFLX, two patients were diagnosed as psittacosis and one as pneumonia associated with TWAR strain by serologic test. Three hundred mg of OFLX was orally administered three times per day and the duration of treatment was from seven to fourteen days, and we compared the clinical effectiveness of OFLX in three cases (mild: 1, moderate: 2) with that of MINO in eleven cases (mild: 3, moderate: 8), who were administered two hundred mg of MINO two times per day orally or intravenously. We isolated C. psittaci from three pet birds including case 2 and the in vitro activity of OFLX and MINO against three strains of C. psittaci was determined. Clinical effectiveness were observed and obtained results were as follows. 1) In OFLX group, three patients judged as "Good", and in MINO, one patient as "Excellent", ten as "Good". 2) The duration of pneumonic shadow was 9.33 +/- 3.21 in OFLX group, 10.3 +/- 3.50 in MINO group, and there was no significant difference between both groups. 3) The in vitro activity of OFLX and MINO against 3 strains was 0.78-1.56 micrograms/ml and 0.025 microgram/ml, respectively. From these results, it was concluded that OFLX was considered to be a useful antichlamydial agent in the treatment of mild or moderate cases of chlamydial pneumonia.
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PMID:[The clinical effectiveness of OFLX in the treatment of chlamydial pneumonia]. 261 88

The current state of causative bacteria in infectious diseases and the trends in resistance to antimicrobial agents were mentioned. The commonest micro-organisms isolated from the blood and intravascular catheter tips were CNS, S. aureus and C. albicans. Significant urine culture isolates were E. coli and other enterobacteriaceae in uncomplicated UTI, and Enterococcus spp. and Pseudomonas spp. in complicated UTI with a urinary catheter. In respiratory tract infections (RTIs), H. influenzae, S. pneumoniae, B. catarrhalis, S. aureus and P. aeruginosa, were common causative organisms. Community-acquired pneumonia was mainly caused by H. influenzae, S. pneumoniae and B. catarrhalis. In common with hospital-acquired pneumonia, P. aeruginosa, S. aureus and enterobacteriaceae were the frequent microorganisms isolated. In anaerobic infections, the most common micro-organisms were B. fragilis and other B. fragilis group isolated from intra-abdominal focus of post operative patients. The trends in the antimicrobial susceptibility of isolates of common bacteria over a period of 5 years (1988-1992) have been monitored. The proportion of isolates of S. aureus resistant to CEZ, CMZ, FMOX, IPM or MINO has increased. There was no trend towards increased resistance among isolates of P. aeruginosa except for CBPC. The incidence of resistance to PCG, ABPC, EM and LMOX increased in isolates of S. pneumoniae and that of resistance to PIPC, CMZ, LMOX and IPM increased in those of B. fragilis group.
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PMID:[Current state of causative bacteria in infections diseases and trends in resistance to antimicrobial agents]. 812 76