Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
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In Addis Ababa, Ethiopia, purified chlamydial antigens were used in a micro-immunofluorescence (micro-I) test to detect type-specific antibodies against various chlamydial species in blood samples from 1846 women attending family planning, prenatal, and postnatal clinics. The antigens were for Chlamydia trachomatis A-C (CTA-C), Chlamydia trachomatis D-K (CTD-K), Lymphogranuloma venereum (LGV 1-3), and C. pneumonia (CPn). The researchers considered sera with antibodies to CTA-C, CTD-K, LGV 1-3, and CPn independently or in combination as evidence of overall exposure to chlamydial species (OEC) and those to CTD-K and LGV 1-3 as evidence of exposure to genital chlamydial pathogens (GENCI). They considered sera with IgM titre of 1/8 or more, or IgG titre of 1/64 or more to CTD-K and LGV 1-3 alone or at a similar level with antibodies to CTA-C and CPn as evidence of active genital chlamydial infection (AGCI). 84% were categorized as OEC. 60% were categorized as GENCI. 42% were categorized as AGCI. The prevalence of chlamydial infection was greatest in family planning clients and lowest in pregnant women (OECD: 88% vs. 78%, p = 0.004; GENCI: 63% vs. 54%, p 0.02; and AGCI: 46% vs. 31%) (p 0.01). The geometric mean of the titre was also highest in family planning clients and lowest in pregnant women (85% vs. 58%). The most significant factor for chlamydial infection was being married and having first coitus before age 13 (OEC: 88% vs. 75% for first coitus at 18 years; p 0.001). Other risk factors included low income (p 0.005), more than 5 sexual partners (p 0.01), bar-girl occupation (p 0.001), and Amhara and Oromo ethnic groups (p 0.001). 50% of all women had clinical evidence of past or present infection in the urethra, fallopian tubes, and/or bartholin glands. Women with pelvic inflammatory disease (PID) were more likely to have chlamydial infection than those with no infection in the urethra, fallopian tubes, or bartholin glands (OEC: 95% vs.83%; GENCI: 86% vs. 58%; AGCI: 72% vs. 38%) (p 0.001). PID was also associated with gonorrhea.
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PMID:Chlamydial infection in a population of Ethiopian women attending obstetric, gynaecological and mother and child health clinics. 886 79

Rationale. Hemoptysis is a rare but often life-threatening condition in pediatric patients. Massive hemoptysis can easily lead to asphyxia, respiratory failure, shock, and even death. The most common causes of severe hemoptysis are lower respiratory tract infection, vascular malformation, and bronchial foreign body. We present an unusual case of massive hemoptysis caused by malformation of the bronchial artery, which includes bronchial artery hypertrophy, bronchial-pulmonary artery fistula, and ectopic bronchial artery. Patient. An 11-year-old boy was admitted to the hospital with mild hemoptysis lasting for the two preceding days. He did not report any discomfort, such as fever or chest pain. His complete blood count and coagulation function were normal. Chest X-ray documented lower right pneumonia. Massive hemoptysis occurred on the night of the admission. Diagnosis. Bronchial arteriography revealed that the right lower bronchial artery and the ectopic bronchial artery from the renal artery were the responsible vessels for hemoptysis. Interventions. The boy underwent a successful bronchial artery embolization and bronchoscopy to remove the blood clot from the airway. Outcomes. After bronchial artery embolization and bronchoscopy, the boy recovered without complications. Hemoptysis and chest pain disappeared, and chest radiographs returned to normal. Lessons. Bronchial arterial bleeding often presents as life-threatening massive hemoptysis. Patients should immediately receive hemostatic treatment and undergo chest CTA, bronchial arteriography, BAE, and bronchoscopy according to their condition. Rapid identification of the etiology and symptomatic treatment are critical to saving the lives of children.
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PMID:Massive Hemoptysis in Children. 3258 44