Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six patients with end-stage emphysema (age 44 +/- 2 years) underwent double lung transplantation (Tx) from June 1988 through May 1990. All suffered from severe inanition and required oxygen therapy. The ischemic time was 193 +/- 28 minutes. Post-Tx immune suppression was OKT3 (14 days), cyclosporine (trough levels of 150 +/- 25 ng/ml), azathioprine to keep WBC at 3,000 to 5,000/cu mm (1 to 3.0 mg/kg/day) and following OKT3, a tapering prednisone regimen. Two rejection episodes that occurred in two patients on post-Tx day 5 and 10 were treated with bolus doses of methylprednisolone. The mean hospital stay was 32 +/- 7 days (range, 20 to 69 days). Four patients required treatment of cytomegalovirus (CMV) infection: gastritis (+donor, +recipient) in one and CMV pneumonia in two (+donor, -recipient). A fourth (+donor, -recipient) had right-sided Candida empyema six weeks post-Tx, developed CMV and staphylococcal sepsis, and died 64 days post-Tx. One patient required pyloroplasty eight weeks post-Tx and one patient underwent tracheal suture line repair at eight weeks. During a follow-up of 81 patients months (range, 8 to 24 months), one patient had developed Epstein-Barr viral (EBV) induced lymphoproliferative disease in the lung and one patient had developed EBV lymphoma. Three patients are at work, one is continuing rehabilitation, and one is at home. Double lung Tx offers a definitive benefit to patients with emphysema; however, a prolonged postoperative course can be expected. Viral infections remain serious but treatable problems.
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PMID:Treatment of end-stage chronic obstructive pulmonary disease with double lung transplantation. 184 23

Several deaths in patients with anorexia nervosa have been ascribed to 'inanition'. The proximate cause of death from inanition has not been established. There are few previous reports of life-threatening hypoglycemia in anorexia nervosa. We participated in the care of two severely cachectic women with anorexia nervosa who were in coma with serum glucose levels of 8 and 14 mg/dl, respectively. Both patients became alert after administration of intravenous glucose. Both were found to have pneumonia at the time of the hypoglycemic event. While the mechanism of the hypoglycemia is unknown, it may be related to the suppression of gluconeogenesis by infection in the setting of reduced substrate, depleted fat stores and decreased catecholamine release.
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PMID:Hypoglycemia and death in anorexia nervosa. 350 7

In the first year (1984) of a reintroduction study, 10 American river otters (Lutra canadensis) from Louisiana were transported to Oklahoma, held for 5 days for clinical evaluation, surgical implantation with intra-abdominal radiotelemetry devices, and then released in Oklahoma. Four of 10 otters released died within 32 days. Clinical evaluation indicated that respiratory tract disease, bacterial and parasitic infections, and inanition may have contributed to the death of these otters. In the second year (1985) of the study, an exotic feline diet was fed, and the holding period for 10 otters was increased to provide time for evaluation and treatment before surgery, postsurgical acclimation to Oklahoma, and reevaluation before release. Although the initial clinical findings on otters in the second year were similar to those found in the first year, otter body weights increased, and the prevalence and severity of clinical abnormalities decreased with treatment during the second-year holding period. Three of 10 second-year otters died during the holding period, and contributing causes of death were determined to be: trauma (hepatic hematoma), inanition, renal disease, pneumonia, salmonellosis (Salmonella anatum), and a retropharyngeal abscess (Klebsiella pneumoniae). Seven healthy otters were reintroduced into Oklahoma in 1985, and postrelease deaths were not experienced.
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PMID:Clinical evaluation and prerelease management of American river otters in the second year of a reintroduction study. 407 27

Eighteen patients with established malignant esophagorespiratory fistulas due to primary esophageal cancer were managed by substernal gastric bypass and isolation of the cancerous esophageal segment. Seven fistulas were esophagotracheal and 11 were esophagobronchial. Ten patients died in the hospital between two days and six weeks after operation. Eight patients left the hospital, surviving an average of 3 1/2 months, but 2 patients lived 5 and 7 months, respectively. Unrelenting respiratory infection and clinical inanition caused 7 hospital deaths in patients reestablished on oral alimentation with their fistulas disconnected. Anastomotic leaks occurred in 5 patients; three of these leaks closed. In the other 2 patients, cervicomediastinal sepsis and bilateral pneumonia with respiratory failure caused death. One patient died of anoxic cardiac arrest 48 hours postoperatively. Fifteen of the 18 patients resumed oral alimentation, but the overall results of palliative surgical therapy achieved in this series were not observably worthwhile for the majority.
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PMID:Pessimism concerning palliative bypass procedures for established malignant esophagorespiratory fistulas: a report of 18 patients. 619 80

Two cases of hypogammaglobulinemia (Bruton's syndrome) in brothers are described. Their sisters had no this disease. Pronounced changes in the lymph nodes, spleen and thymus typical for this condition were combined in both cases with lung and kidney malformations as well as with chronic pneumonia and inanition. The both boys have viral respiratory infections that followed by marked antibody formation and clear-cut structural alterations characteristic of different stages of these diseases. Besides this the older brother was found to have chronic viral hepatitis B with an unusual giant-cell reaction.
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PMID:[Features of the manifestations of bronchopulmonary pathology and hepatitis B in children with hypogammaglobulinemia]. 672 6

The carcass of a 15-year-old female Bottlenose dolphin (Tursiops aduncus) was retrieved from the Port River near Adelaide, South Australia, Australia. The animal was emaciated with five thick nylon fishing lines emerging from the oropharynx attached to a tangle of nylon and monofilament fishing line that also contained wire and eight fishing hooks. The mouth had been cut by the line and a circumferential curvilinear superficial abrasion/indentation from fishing line encircled the entire distal rostrum. Dissection of the upper aerodigestive tract revealed a large fish hook embedded in the lower blowhole associated with an adjacent abscess at the base of the epiglottis. The stomach contained two unattached fish hooks, parts of a plastic squid lure and two heavy duty work gloves. Further examination revealed a severe necrotising pneumonia with microabscesses in the kidneys and adrenal glands with scattered thromboemboli in keeping with terminal disseminated intravascular coagulation. Death had resulted from septic complications of fishing hook impalement and line entanglement with inanition. The case provides a graphic illustration of the effects of entanglement and fishing hook penetration, as well as ingestion of non-degradable plastic materials, in a free living Bottlenose dolphin.
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PMID:Lethal fishing hook penetration and line entanglement in an adult bottlenose dolphin (Tursiops aduncus). 3212 29