Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The availability of techniques such as surgical reperfusion, angioplasty, and thrombolysis for the treatment of acute myocardial infarction (AMI) has revived interest in seeking an early detectable biochemical marker diagnostic for AMI. Therefore, we investigated whether an unidentified oxidase that is released by activated neutrophils at the onset of AMI could be used as an early diagnostic assay. The conversion by plasma oxidase of 1 microM of adrenaline to 1 microM of adrenochrome represents the plasma oxidase activity (POA) of 1 U/L. Fifty patients suspected of having AMI, 40% of whose electrocardiograms were nondiagnostic for AMI, were admitted to the coronary care unit, and venous blood samples were obtained for determination of the POA and creatine phosphokinase-MB levels. Healthy volunteers (n = 12) served as control subjects, and 8 patients with pneumonia whose leukocyte counts were greater than 15,000 microL were included in the study. In those with AMI (n = 22), as determined by serial creatine phosphokinase-MB, the mean POA (+/- standard error of the mean) was 233 +/- 13 U/L, and in those with angina and no AMI (n = 28) was 127 +/- 5 U/L (P < 0.0001). In the control group, mean POA (+/- standard error of the mean) was 84 +/- 5 U/L (control versus angina; P < 0.01) and for those with infection was 214 +/- 10 U/L. At admission, the creatine phosphokinase-MB was diagnostic for only 12 of the 22 patients with AMI (sensitivity rate of 54%), whereas in 21 of those patients, the POA values were diagnostic for AMI (sensitivity rate of 95%).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Plasma oxidase assay for screening of myocardial infarction. 807 31

The studies aimed at assessing the kind and the incidence of the complications of monocytic angina in childhood. In 7 out of 343 hospitalized children neurological disorders were found, thrombocytopenia was seen in 5 cases, pneumonia in 3 cases, bronchitis in 12 cases, and AV block in 3 cases. The most frequent complication of monocytic angina was respiratory tract obturation (6.4% of cases).
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PMID:[Complications of monocytic angina in children]. 823 52

There is controversy whether the short-term and long-term results of coronary artery bypass surgery in elderly patients justify the commencement of the procedure. Between February 1988 and July 1992, 113 patients underwent CABG in our hospital, of whom 15 (13.3%) patients were 75 years old or older (mean 76 years). They consisted of 5 men and 10 women, and all were in New York Heart Association class III or IV. Unstable angina was observed in 13, left main trunk stenosis was in 4, and left ventricular dysfunction, ejection fraction of less than 0.30 was in 2 of 15 patients. The mean number of bypass grafts was 2.7 per a patient, and only autologous greater saphenous vein was used. In seven (47%) cases, CABG was performed urgently or emergently. There was neither operative nor hospital death, although some complications occurred in 11 (73%) patients. Post-operatively, 13 patients were in NYHA class I and 2 in class II. Only one patient died of pneumonia one year after operation. Although high risks of operative mortality and morbidity with coronary artery bypass surgery for elderly patients, particularly in urgent or emergent cases, had been reported, the long-term survival rate and freedom from angina were excellent, justifying continuous commencement of coronary bypass surgery in the selected patients over 75 years of age.
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PMID:[Coronary artery bypass surgery in patients older than 75 years of age]. 828 87

Medical records of 876 servicemen of a young age who have suffered various forms of clinical diphtheria were analysed. (Lethal cases were marked in 52 cases--5.9%). A true clinical symptom complex for the diagnosis of diphtheria at pre-hospital period is as following: fever, intoxication and febrinous tonsillitis. The main cause of unfavourable outcome of the disease depends on the affection of cardiovascular, central and peripheral nerve systems by diphtheritic exotoxin. The most frequent limitations during medical care were the following: error diagnosis of angina (41%), late hospitalization and late specific treatment, insufficient doses of antidiphtheric serum, inopportune diagnosis of severe aggravations (infectious toxic shock, pneumonia).
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PMID:[The diagnostic and treatment characteristics of diphtheria in troop units and military medical institutions]. 830 51

Anderson Area Medical Center physicians have been provided disease and procedure specific profiles of their practice experience for more than five years. For four years, physicians were provided reporting, in a variety of formats, detailing their clinical outcomes and consumption of hospital resources in treating patients with acute myocardial infarction (AMI), pneumonia, cholecystectomy, stroke, congestive heart failure (CHF), and total hip replacement. For the past eighteen months physicians have been provided a uniform format of monthly physician-specific reporting for stroke, AMI, pneumonia, diabetes, CHF, cholecystectomy, total hip replacement, newborn delivery, angina, and hernia repair. Using only a modest PC platform with database, word processing, and graphics programs operating in a DOS environment, an effective disease/procedure reporting program is provided to medical staff with 3 person-days of effort per month.
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PMID:Lowering physician hospital resource consumption using low-cost low-technology computing. 856 69

For three years we studied the mortality and functional situation of all patients admitted in 1991 to the Neurology Service suffering from acute stroke with the exception of subarachnoid haemorrhage cases. We analyzed the cause of death whether directly related to the initial illness or not. Out of 134 patients admitted for acute stroke, 48 (41.02% of the 117 patients examined after excluding 17 whom we did not obtain complete information from) had died after three years. The main causes of death were directly related to acute stroke (37.5%) and pneumonia (37.5%). Death occurred mainly in the first month (79.16% of deaths). Predictive variables for mortality directly related to acute stroke during the first month include severe weakness, brain haemorrhage, dysphasia and earlier incidence of acute stroke. Variables related to higher mortality rate due to other causes in the first month were dysphasia, age and angina antecedents, whereas earlier incidence of acute stroke was associated with a lesser mortality rate for these causes, as distinct from acute stroke itself. Greater levels of weakness and sphincteral incontinence are the best predictive signs of dependency functional situation at the end of the first month and, along with diabetes, after one and three years.
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PMID:[3 year survival in patients hospitalized for acute cerebrovascular disorders]. 871 89

This review is based on longitudinal studies on our seven patients with congenital generalized lipodystrophy, our patient with acquired generalized lipodystrophy, and published papers on these subjects. An inability to store energy in adipose tissue is of pathogenetic importance. In congenital lipodystrophy, insulin resistance is present from birth, resulting in hyperinsulinaemia, dyslipidaemia. and insulin-resistant diabetes with an anabolic syndrome worsened by a voracious appetite. Clinically, we observed increased height velocity in pre-school age children, and organomegaly with hypertrophic cardiomyopathy, which seems to be lethal in early adulthood: three of our patients died at the ages of 24, 32 and 37 years. The oldest alive, 39 years, suffers from stenocardia. Regarding treatment, it is most important to reduce energy consumption. The congenital form is recessively inherited. The aetiology may be related to insulin receptor or postreceptor mechanisms. Acquired generalized lipodystrophy seems to be an autoimmune disorder with secondary destruction of the adipose organ: the anabolic syndrome with insulin-resistant diabetes is secondary. Our patient died when 24 years old from pneumonia.
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PMID:Generalized lipodystrophy, congenital and acquired (lipoatrophy). 878 69

Clinical data and outcomes of 18 patients, aged 80 or older, on continuous ambulatory peritoneal dialysis (CAPD) during the last five years were reviewed. There were 12 males and 6 females, with a mean age of 85 (range 82-91 years) and median duration on CAPD of 31.5 months (range 2-58 months). End-stage renal disease was caused by nephrosclerosis in 9, diabetes mellitus and light chain disease in 2 each, and chronic glomerulonephritis, membranous nephropathy, and IgA nephropathy in 1 each, with the cause unknown in yet another 2 patients. Hypertension and angina were the commonest comorbid conditions observed. Peritonitis episodes occurred one per 10.8 patient-months, and necessitated catheter removal in 7 patients and reinsertion in 6 of them. Fourteen episodes of exit-site infections were seen in 8 patients, 2 developed pericatheter leak, and 1 had tunnel infection. Nine patients are continuing CAPD successfully, with a median duration of 29 months (range 11-57 months). One patient was transferred to hemodialysis, and 8 died. The causes of death were peritonitis (3/8), cerebrovascular accident (2/8), pneumonia (1/8), and septicemia (1/8), with the cause not known in 1 patient. Our survival rate of 80% at three years is encouraging, and we advocate CAPD as a successful alternative treatment modality in octogenarians.
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PMID:Successful use of continuous ambulatory peritoneal dialysis in octogenarians. 886 86

Invasive group A streptococcus (GAS) infections are emerging diseases; however, person-to-person transmission of invasive GAS producing life-threatening infection has been observed rarely. We report a small intrafamilial cluster of life-threatening GAS infections. A previously healthy 47-year-old father developed necrotizing fasciitis of the neck. Two days later, his 16-year-old daughter developed streptococcal angina, pneumonia, and pleural empyema. Both patients had signs of streptococcal toxic shock syndrome. Pulsed field gel electrophoresis revealed that the M6 strains of GAS isolated from the father and daughter had identical patterns. Cases of person-to-person transmission of invasive GAS infection reported in the literature are also reviewed.
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PMID:Familial transmission of a serious disease--producing group A streptococcus clone: case reports and review. 919 67

The most common diagnoses of elderly patients in the emergency department (ED) were compared among three age subgroups: 65 to 74, 75 to 84, and 85 and older. The computerized billing records for patient visits to 10 northern New Jersey hospital EDs for the years 1985 to 1991 were retrospectively analyzed. The most frequently occurring ICD-9-CM codes for elderly patients were compared among the three age subgroups. Elderly persons comprised 174, 146 (14% of the total) patient visits. The 176,146 patient visits were assigned 259,440 ICD-9-CM codes. The most common ICD-9-CM codes for medical diagnoses included chest pain, cardiac dysrhythmias, congestive heart failure, syncope, abdominal pain, and dyspnea. Fractures, particularly of the lower limb and upper limb; contusions; open wounds, particularly of the head, neck, and trunk; and falls were among the most common trauma diagnoses. The proportions in the three age subgroups of each diagnosis were statistically significantly different, except for cardiac arrest and contusions of the trunk and of multiple sites. The diagnoses with clinically significant higher relative risks in older age subgroups were atrial fibrillation, congestive heart failure, syncope, hypovolemia/dehydration, gastrointestinal hemorrhage, dyspnea, pneumonia, pulmonary edema, cerebrovascular accident, septicemia, urinary tract infection, fractures, and open wounds of the head, neck, trunk, particularly the scalp, and falls. Clinically significant lower relative risks were found in older age subgroups for chest pain, acute myocardial infarction, hypertension, angina, chronic airway obstruction not elsewhere classified, epistaxis, contusions of the upper limb, and open wounds of the finger.
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PMID:Age-related differences in diagnoses within the elderly population. 945 12


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