Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0032285 (
pneumonia
)
54,520
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This is a report of the case of a patient with acute promyelocytic leukemia treated with all trans-retinoic acid (ATRA), who had suspected all-trans retinoic acid syndrome (
ATRA syndrome
). The nonspecific febrile leukopenia observed justified the association with antimicrobial and antifungal therapy. Signs and symptoms contributed to the suspicion of
ATRA syndrome
, and renal function was impaired by the combination with antifungal agents. The decrease in renal function observed initially contributed to the suspicion of
ATRA syndrome
and was aggravated by antifungals. Thus, the use of ATRA was discontinued. Eight days after the
pneumonia
characterization, the possibility of
ATRA syndrome
was dismissed. In this context, ATR's nephrotoxicity and the synergic adverse effect by the use of nephrotoxic antifungal agents were discussed, particularly amphotericin B, as well as the importance of differential diagnosis between
ATRA syndrome
and infectious diseases.
...
PMID:[Acute renal failure in patient treated with ATRA and amphotericin B: case report]. 2178 47
