Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eight elderly undernourished patients with bronchopneumonia were admitted into the clinic for treatment as well as intentive, combined parenteral-peroral nutrition. The improved protein status achieved was evidenced by a significant increase in the serum concentration of total protein, prealbumin and retinol-binding protein. There was a significant decrease of haptoglobin in all patients, measured in the upper normal range, even though it was extremely high at the onset of therapy due to the inflammatory process. These findings emphasize the influence of consequent nutritional therapy in the treatment of pneumonia, especially for elderly patients.
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PMID:[The effect of combined parenteral-peroral nutrition on the protein status of undernourished elderly patients]. 11 Jun 77

Serum haptoglobin (Hp) concentrations were measured in swine that were naturally or experimentally infected with Actinobacillus pleuropneumoniae. In swine from a specific-pathogen-free herd, mean serum concentration of Hp (+/- SD) was 5.79 +/- 1.06 mg of cyanmethemoglobin-binding capacity (CHBC)/dl. Serum Hp concentrations in paired samples were measured at 7-day intervals in 40 swine randomly selected from a conventional herd that was experiencing an acute episode of pneumonia and deaths caused by A pleuropneumoniae serotype-5 infection. Day-0 and -7 serum Hp concentrations were 24.58 +/- 1.38 and 23.10 +/- 1.12 mg of CHBC/dl, respectively, with no significant difference between these measurements. In a second conventional herd with a history of chronic infection with A pleuropneumoniae serotype 5, serum concentrations of Hp measured in paired samples obtained 6 days apart were 12.36 +/- 0.81 and 18.63 +/- 0.76 mg of CHBC/dl, respectively, and were significantly (P < 0.05) different from each other. Twenty-nine 12-week-old conventional swine were challenged intranasally with A pleuropneumoniae serotype 1 (n = 19) and serotype 5 (n = 10). Serum Hp concentration increased from prechallenge concentrations of 7.49 +/- 1.38 and 15.10 +/- 1.22 mg of CHBC/dl, respectively, to 41.01 +/- 1.35 and 22.37 +/- 1.78 mg of CHBC/dl, respectively, 72 hours after challenge. For these 29 swine, serum Hp concentration was positively correlated with rectal temperature (r = 0.34; P < 0.001) during the immediate postchallenge period.
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PMID:Serum haptoglobin concentration in swine naturally or experimentally infected with Actinobacillus pleuropneumoniae. 129 15

We report herein a 61-year-old man with chronic cold agglutinin disease which occurred after a diagnosis of aplastic anemia. The patient's pancytopenia was recognized upon visiting a local doctor because of high fever and cough on December 21, 1985. He was subsequently admitted to our hospital because of anasarca on January 31, 1986, and was diagnosed as having aplastic anemia. He was treated with prednisolone, and was discharged after his anemia improved. He was readmitted on October 23, 1988, because of icterus. Laboratory data on the patients second admission revealed increased reticulocyte count, hyperplastic bone marrow with a predominance of erythroblasts, increased serum indirect bilirubin, increased serum LDH1 value and decreased serum haptoglobin. Moreover, cold agglutinin titer was increased, anti-IF antibody was positive, and anti-IgM antibody was recognized with direct anti-globulin test. There was no precedent infection such as mycoplasma pneumonia or infectious mononucleosis. Hence, this patient was diagnosed as having chronic cold agglutinin disease.
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PMID:[Chronic cold agglutinin disease occurring after a diagnosis of aplastic anemia]. 154 14

We determined serum levels of alpha 1-antitrypsin, alpha 1-acid glycoprotein, ceruloplasmin, haptoglobin, alpha 2-HS glycoprotein, C3 and fibronectin in 22 patients with acute pneumonia, 10 patients with mycoplasma pneumonia and 8 patients with exacerbation of chronic bronchitis at both acute and convalescent phases to clarify whether levels of these proteins change with inflammation. Serum levels of alpha 1-antitrypsin, alpha 1-acid glycoprotein, ceruloplasmin, haptoglobin and C3 in the patients in the acute phase were significantly higher than that in the patients in the convalescent phase. The serum level of fibronectin in the patients in the acute phase was significantly lower than that in the patients in convalescent phase. The serum level of alpha 2HS glycoprotein remained unchanged.
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PMID:[Changes in various serum protein levels between acute and convalescent phases in patients with respiratory infections]. 169 92

Humoral immunity, body reactivity, reparative function of connective tissue were investigated in 45 patients with poor-symptom acute pneumonia and in 29 lingering pneumonia cases. The patients were examined for the content of IgM, IgG and IgA, haptoglobin, seromucoid, collagen metabolism (by oxyproline) on treatment days 1-5 and 15-25. With prolongation of the inflammation resolution and transformation of the disease into a lingering form, there appeared an imbalance of immunoglobulins manifested by low values of IgG and IgA. The latter immunoglobulins being the most active in body defences, this reflects disturbances in the mechanism of humoral immunity responsible for antiinfectious activity. Haptoglobin concentrations were of certain diagnostic significance, its level being higher in lingering pneumonia. In addition, oxyproline (total and bound) level rose thus evidencing catabolism predominance over collagen synthesis. This may underline delayed repair of the connective tissue in the lungs. Seromucoid, on the contrary, proved an unreliable sign. It is concluded that the level of immunoglobulins (IgG and IgA, in particular) as well as high blood haptoglobin and oxyproline with its components can be considered risk factors for poor-symptom pneumonia progression into a lingering one.
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PMID:[Various indicators of early diagnosis of the protracted course of acute pneumonia]. 233 50

The concentrations of plasma ceruloplasmin, plasma fibrinogen, serum haptoglobin and the major cell types in blood together with liveweight changes were monitored during the acute phase response in sheep. Five control sheep, five sheep that underwent sham bronchial obstruction, and five sheep that developed pneumonia after bronchial obstruction were examined. Blood samples were taken and liveweights were recorded from four to six days before until 14 days after the surgical operations (sham and bronchial obstruction). The operations led to an acute phase response in the sheep and the development of pneumonia increased and sustained the response or led to a secondary response. Statistically significant changes observed in the blood of the sheep during the acute phase response included increased concentrations of plasma ceruloplasmin and plasma fibrinogen, depression of erythrocyte numbers and elevation of neutrophil numbers (means on day of maximum change as percentage of pretreatment values; 250 per cent, 400 per cent, 80 per cent and 200 per cent, respectively). Serum haptoglobin showed a pronounced and significant increase in concentration (over 6000 per cent of pretreatment values in some sheep). All three groups of sheep showed significant depression of liveweight after overnight confinement in the surgery but this was sustained for the period of the experiment only in the bronchial obstruction group. The results indicated that measurement of the concentrations of the three plasma proteins may be more useful in the diagnosis of tissue injury and infectious disease than the number of circulating neutrophils in sheep.
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PMID:Acute phase response of sheep: changes in the concentrations of ceruloplasmin, fibrinogen, haptoglobin and the major blood cell types associated with pulmonary damage. 246 10

Certain derivatives of the 8-aminoquinolines have been shown to affect some blood constituents and haemopoiesis, to induce functional changes in the central nervous system, and to cause other organ lesions. The 8-aminoquinolines vary widely in their toxicity and ability to induce tissue damage in different laboratory animals. In the present study, the subacute toxicity of primaquine was studied in beagle dogs, rhesus monkeys, and albino rats. Based on body weight, the dog was more sensitive to primaquine than the monkey, while the rat was the least sensitive. In all three species, primaquine elevated the levels of serum transaminases, decreased the level of fasting blood glucose, and caused inflammatory and degenerative changes in the liver and kidneys. In addition, primaquine caused pneumonia and elevation of serum haptoglobin in the dog; erythrocytopenia in the monkey; reticulocytosis and the presence of nucleated erythrocytes in the rat; methaemoglobinaemia, thrombocytopenia, and inflammatory and degenerative changes of striated muscle (including the myocardium, diaphragm, tongue, and skeletal muscle) in the dog and rat; oedema and gliosis of the cerebral cortex in some monkeys; lymphoid depletion in the dog and monkey; and bile duct hyperplasia in some rats.
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PMID:Subacute toxicity of primaquine in dogs, monkeys, and rats. 697 51

In search of reliable genetic markers of protracted and complicated pneumonia, the authors studied blood groups, haptoglobin phenotype, sulfadimisine acetylation. These markers proved essential for predicting pneumonia course and prognosis.
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PMID:[The role of clinico-pharmacogenetic associations in the prognosis of the outcomes in pneumonias]. 820 55

Relationship was studied between the polymorphism of alpha 1-antitrypsin (Pi), haptoglobin (Hp) and transferrin and the development of chronic unspecific impairment of children lungs. Combination of protein isoforms PiM3M3 and Hp 1-1 was found to increase the risk of the lungs unspecific impairments in persons with lingering pneumonia and caused more severe development of the disease. Relatively low activity of the isoform PiM3M3, as compared with other forms of the PiMM system, and more intensive and nonadequate rate of lipid peroxidation in patients containing HP 1-1 appear to be responsible for aggravation of these impairments.
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PMID:[Isoprotein composition of alpha 1-antitrypsin, haptoglobin, transferrin, and lipid peroxidation in the blood in inflammatory lung diseases in children]. 830 77

Thirty-nine patients with non-Hodgkin's lymphoma were treated with weekly alternating non-cross-resistant chemotherapy (CAMBO-VIP). We obtained a high response rate, and prolonged disease-free survival with side effects and complications of various severity were observed. Three patients were withdrawn from the study due to aggravation of liver cirrhosis, cerebral infarction, and poor tolerance. Thirty-six patients completed this 12-week intensive chemotherapy. The median treatment delay in all patients was 3 days (-4 to 29 days), and a delay of over 15 days was seen in 5 patients. The nadir of the neutrophil count was 0 to 2,100/microliters (median 140/microliters), and 15 patients were below 100/microliters. Two patients had pneumonia and 4 had herpes zoster infection. The platelet count nadir was 20,000 to 240,000/microliters (median 90,000/microliters). Ten patients were below 50,000/microliters, but none required platelet transfusion. Red cell transfusion was given in 6 patients. Elevation of transaminases was seen in 25 patients, but it was not serious except for a patient with liver cirrhosis. The elevation of serum LDH level and decrease of serum haptoglobin level seen shortly after completion of treatment seemed due to the increased blood cell destruction. Stomatitis was observed in 32 patients, 17 of whom showed more than grade 3 toxicity. Blister formation on palms and/or soles was noted in 6 patients. There was no treatment-related death observed.
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PMID:[A study of toxicities and complications observed in alternating non-cross-resistant chemotherapy (CAMBO-VIP) for non-Hodgkin's lymphoma]. 833 48


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