Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty-four patients with limited extent American Joint Committee on Cancer Stage II-III non-small cell carcinoma of the lung were randomly assigned to potentially curative radiation therapy plus one of two schedules of razoxane. The weekly schedule was 1 gram per square meter body surface area (BSA) every 8 hours for two doses per week, and the daily schedule was a fixed dose of 250 mg per day. The 50% Kaplan-Meier survival estimate for both groups combined was 9 months. There was no survival difference between the two dose-schedules. Toxicity was formidable with an 82% incidence of esophagitis, and a 20% incidence of grade III-IV esophagitis. Fifty-nine percent of patients developed hematologic toxicity. This was greater with the weekly dose-schedule (P = 0.01). Forty-one percent of patients developed radiographic or symptomatic pneumonitis. One patient developed a fatal myelitis. This program is no more effective than irradiation alone, and has substantial morbidity.
 ...
PMID:Radiotherapy plus razoxane for advanced limited extent carcinoma of the lung. 632 61

Results of examination of 143 patients with the lung infiltrative lesions of various etiology (tuberculosis, carcinoma, acute pneumonia) are analysed. Cytological examination of the sputum, bronchial smears and lavage liquid allowed one to diagnose cytologically lung carcinoma in 67% and tuberculosis in 36% cases. Certain combinations of nonspecific cell elements in the bronchial content also helped to make the differential diagnosis between the infiltrative tuberculosis, carcinoma and acute pneumonia. The most informative is the examination of the lavage liquid.
 ...
PMID:[Potentials of the cytological method in the differential diagnosis of infiltrative processes of various etiology in the lungs]. 652 65

In a retrospective study of thirty-one immunosuppressed patients with new pulmonary infiltrates transbronchial biopsy provided a specific diagnosis in 11 of the 31 (36%) patients. In a further five patients, whose biopsy showed non-specific interstitial pneumonitis, a specific diagnosis was established by other means. Overall a specific diagnosis was obtained in 52% of patients. Twelve patients were left with a diagnosis of non-specific interstitial pneumonitis. In three out of 31 (10%) patients insufficient tissue was obtained. The seven patients who had metastatic carcinoma of the lung did poorly. The nine with other specific diagnoses did better in that five of them were alive after more than 11 months of follow-up. Patients with non-specific pneumonitis did well; eight out of 12 (67%) were alive after an average follow-up of 13.4 months. In 27 of the 31 (87%) patients the procedure was felt to have influenced therapeutic decisions. This was true whether the biopsy yielded a specific or a non-specific diagnosis. In our series making a specific diagnosis did not improve the patients' survival. Those with non-specific pneumonitis who were treated empirically did well, as did patients with specific diagnoses other than metastatic carcinoma of the lung.
 ...
PMID:Usefulness of transbronchial biopsy in immunosuppressed patients with pulmonary infiltrates. 685 72

The difficulty in classifying pulmonary infection within areas of bullous emphysema may have contributed to the lack of appreciation of this entity. This process is important to recognize because: (1) the clinical picture is usually benign:; (2) it may be confused with tuberculosis, fungal disease, and carcinoma of the lung; and (3) radiographic resolution may be slow. For these reasons, pneumonitis which occurs within emphysematous lung may have been previously considered as slowly resolving pneumonias. The development of air-fluid levels within bullae has been called "infected emphysematous bullae." We believe that this phrase is misleading since there are no bacteriologic data to support the presence of infection within the bullae containing fluid. In fact, direct sampling of intrabullous fluid has been rarely reported and, if obtained, has been generally negative for bacteria. Furthermore, the clinical course in our patients is alos not consistent with infection within a space. Once fiberoptic bronchoscopy has excluded an obstructing endobronchial lesion, the physician may patiently follow the anticipated gradual resolution. We suggest that the phrase, "periemphysematous lung infection" best describes these related clinical-radiological conditions.
 ...
PMID:Peri-emphysematous lung infection. 691 23

The platelet aggregation test was used to detect circulating immune complexes (CIC) in 567 patients admitted to a general hospital. One hundred and fourteen or 20.1% had positive tests compared to seven or 5.4% of 129 normal controls. When the hospitalized population was analyzed by disease group, significantly elevated CIC levels were found in 27 disease categories, including several common conditions not generally considered to be immunologically mediated, such as angina pectoris, myocardial infarction, congestive heart failure, pneumonia, pulmonary emboli, diabetes mellitus, infarction of the bowel, and carcinoma of the lung. These results indicated that an important problem in the interpretation of CIC levels in a particular condition may be the presence of complexes caused by common diseases coexisting with the condition being studied.
 ...
PMID:Circulating immune complexes in unselected patients admitted to the medical service of a general hospital. 706 76

In 1976, 220 patients over 15 years of age were admitted to the adult medical services of Aurora Hospital, Helsinki, with a provisional diagnosis of pneumonia. All patients had an infiltrate on the chest X-ray. Acute pneumonia was found in 193 patients (87.7%). Other diseases in this series were pulmonary tuberculosis in 14 cases (6.4%), carcinoma of the lung in 6 cases (2.7%), and carcinoma of the lung with acute pneumonia in 5 cases (2.3%), aspergilloma in one case (0.5%) and an eosinophilic infiltrate in one case (0.5%). Previous or associated illnesses in the pneumonia patients were previous pneumonia (40.4%), chronic alcoholism (26.8%) and congestive heart failure (25.8%). The probable infectious aetiology of pneumonia was found in 45 cases (22.7%). The commonest agents were influenza A, 17 cases (8.6%); Pneumococcus, 9 cases (4.6%); and Mycoplasma pneumoniae 8 cases (4.0%). Bacteria were accepted causal if grown from blood cultures; tests for detecting antibodies against Pneumococcus were not used. Sputum cultures were not helpful in the study of bacterial pneumonia. Alcoholism seemed to predispose to pneumococcal pneumonia, but in the alcoholic patients leukocyte counts on admission were not lower than in the other patients. The overall mortality of pneumonia was 5.5%, only 3.5% of patients died during the first 3 weeks.
 ...
PMID:Outcome of patients admitted to the hospital with suspected pneumonia. 744 65

A phase I trial of paclitaxel therapy, administered as a weekly 3-h infusion for 6 weeks with concurrent daily thoracic radiation to patients with advanced or medically inoperable non-small cell lung cancer, was performed. Paclitaxel was escalated in increments of 10 mg/m2/week in successive cohorts of three new patients as tolerated, starting at 10 mg/m2/week. Radiation was administered to the primary tumor and regional lymph nodes (40 Gy over 4 weeks), followed by a boost to the primary tumor (20 Gy in 2 weeks). Twenty-seven patients entered this study through seven dose levels of paclitaxel ranging from 10-70 mg/m2/week for the primary purpose of evaluating the toxicity of concurrent chemoradiation treatment. Esophagitis was the principal and dose-limiting toxicity. Radiation pneumonitis occurred in two patients. Other toxicities were mild. Although not designed as an efficacy study, 23 patients were available for response, and an overall response rate of 74% (confidence interval, 65-83%) was observed.
Lung Cancer 1995 Jun
PMID:Concurrent paclitaxel and thoracic radiation for advanced non-small cell lung cancer. 755 42

We reviewed CT scans in 38 cases with pathologically proved bronchioloalveolar carcinoma. CT revealed three CT patterns: solitary, pneumonic and diffuse forms. The solitary pattern (22 patients) had a high percentage of air bronchograms (95%), pleural indentation (77%) and spiculation (68%). The pneumonia-like pattern (16 lesions in 10 patients) had air bronchograms in all cases (100%), low attenuation (88%) and protrusion of interlobar fissures (63%). The diffuse form (six patients) had 2 or 3 mm diffuse small nodules scattered throughout the entire lung. CT of bronchioloalveolar carcinoma revealed many findings and was useful in recognizing the tumor distribution and extent. We conclude that CT is helpful for the diagnosis and evaluation of bronchioloalveolar carcinoma.
Lung Cancer 1995 Jun
PMID:CT scanning of bronchioloalveolar carcinoma: specific appearances. 765 31

A 48-year-old man was admitted for the evaluation of a massive left pleural effusion. Thoracenthesis yielded a bloody excudate with a high percentage of eosinophils (27%) and high values of pancreatic enzymes (amylase 16,000 Somogyi, Elastase 35,000 ng/dl, Lipase 12,800 U/l, Trypsin 77,000 ng/ml). The amylase isozyme of the exudate was 100% pancreatic-type fraction. The blood showed no eosinophilia (4%). A computed tomographic scan and magnetic resonance image of the abdomen revealed a pancreatic pseudocyst in contact with the diaphragm, and thrombi in the inferior vena cava and the splenic vein. After pancreatic cystectomy and splenectomy, the pleural effusion resolved rapidly. Eosinophilic pleural effusion has been reported as a complication of several disorders: pneumonia, lung carcinoma, pulmonary tuberculosis, and pulmonary infarction. However, we know of no previous report of eosinophilic pleural effusion with pancreatitis. In this case, it is interesting that the massive eosinophilic pleural effusion associated with chronic pancreatitis resolved immediately after the operation, and the patient was discharged.
 ...
PMID:[A case of chronic pancreatitis with eosinophilic pleural effusion]. 766 23

To evaluate the effectiveness of vinorelbine (NVB) in patients with non-small cell lung cancer (NSCLC), a late Phase II study was conducted. A total of 80 patients with Stage III or IV NSCLC who had no previous therapy were entered into the study. Seventy-nine patients were eligible for response and toxicity. NVB was administered weekly by intravenous injection at a dose of 25 mg/m2 in 20 ml of saline and was generally administered in four cycles or more, unless patients had disease progression. Of the 79 eligible patients, 23 (29.1%) showed a partial response (95% confidence interval, 19.1-40.4%). The median duration of partial responses was 14.7+ weeks. The median survival time for all patients was 40.1+ weeks. The major toxicity was leukopenia. Grade 3 and 4 leukopenia occurred in 48 patients (60.8%). Other toxicities of grade 3 or more included anemia (6.3%), local cutaneous reaction (3.8%), pneumonitis (1.3%), nausea and vomiting (1.3%), mucositis (1.3%) and constipation (1.3%). The absolute dose-intensity of NVB was 22.33 mg/m2/week. A weekly schedule of intravenous administration of 25 mg/m2/week of NVB was reasonable for maintenance of activity, and acceptable for toxicity in the chemotherapy of advanced NSCLC.
Lung Cancer 1994 Dec
PMID:A phase II study of vinorelbine, a new derivative of vinca alkaloid, for previously untreated advanced non-small cell lung cancer. Japan Vinorelbine Lung Cancer Study Group. 770 95


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>