Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Atypical interstitial pneumonia is described as two clinical syndromes in young cattle. One syndrome occurs in animals which have clinical evidence of pneumonic pasteurellosis, responds initially to treatment for one to two days and then develops acute signs of atypical interstitial pneumonia. The second syndrome involves acute respiratory distress in young calves due to atypical interstitial pneumonia with antecedents of enzootic pneumonia. The postmortem lesions are described along with discussion of the possible pathogenesis of the condition and treatment.
 ...
PMID:Atypical interstitial pneumonia in cattle. 48 61

Lesions in sheep with ovine progressive pneumonia are described. Lungs were mottled grayish-pink, firm, and large (two to three times normal weight). There was chronic diffuse interstitial pneumonitis characterized by extensive hyperplasia of lymphoid cells around airways and blood vessels and by accumulation of mononuclear cells in the interstitium. In some lungs, this reaction was accompanied by excessive fibrous tissue and smooth muscle and less frequently by hyperplastic epithelium of terminal bronchioles and alveoli. Secondary bronchopneumonia was common. Lymphocytic meningitis, choroiditis, and leukoencephalitis were seen in a few sheep. Meninges and choroid plexuses were infiltrated with lymphoid cells, and subependymal blood vessels were cuffed with lymphoid cells. Much subependymal white matter was demyelinated and had foci of necrosis and gliosis.
 ...
PMID:Lesions of ovine progressive pneumonia: interstitial pneumonitis and encephalitis. 52 55

Thirty-eight immunocompromised patients underwent transbronchial lung biopsy via the fiberoptic bronchoscope as part of a diagnostic evaluation for fever and roentgenographic evidence of a new pulmonary infiltrate. Diagnostic information was obtained from lung biopsy in 29 patients (76%), with infection accounting for ten cases and a nonspecific interstitial pneumonitis in 13 patients. Concomitant bronchial brushings were diagnostic in only three patients (all with infections). Diffuse roentgenographic infiltrates were expecially amenable to bronchoscopic lung biopsy diagnosis (84%), while in localized infiltrates, there was only a 43% diagnostic yield. Although thrombocytopenia and hypoxemia were common in these patients, morbidty was low (four patients had pneumothoraces with no noteworthy bleeding) and there were no deaths resulting from this procedure. Prebiopsy platelet transfusions were used in five patients with severe thrombocytopenia (platelet cound, less than 50,000/cu mm). The diagnostic efficiency and low morbidity associated with transbronchial lung biopsy indicate that this procedure can safely play a role in the evaluation of pneumonia in the compromised host.
 ...
PMID:Transbronchial lung biopsy in the compromised host. 57 93

The lung lesions produced by multiple short-term intratracheal instillations of saline solutions of sodium zirconium lactate (NaZL), zirconium-aluminum-glycine hydroxychloride complex (ZAG), and aluminum chlorhydrate (ACH) in hamsters were studied by light and electron microscopy. These solutions produced lesions beginning with exudative pneumonia followed by pneumonitis (interstitial pneumonia) and foreign body granulomas. Electron microscopic microprobe analysis demonstrated the metallic component of the instilled compounds in membrane-bound cytoplasmic inclusions of macrophages. The lesions produced by NaZL and ZAG were similar to those produced by ACH. These lesions were also similar to those in previous reports of aerosol exposure of animals to zirconium or aluminum, or to other unrelated compounds.
 ...
PMID:Acute lung lesions due to zirconium and aluminum compounds in hamsters. 57 87

An aerosol model for the study of paraquat (PQ) toxicity was developed using a 134 litre chamber and an ultrasonic nebuliser. Three groups of New Zealand white rabbits weighing 2-3 kg were studied. Group I (n = 6) was exposed to 10 g PQ/100 ml double-distilled water (DDW), Group II (n = 24) was exposed to 200 mg PQ/100 Ml DDW and a control group (n = 6) was exposed to 100 ml DDW. In a second experiment ten animals (Group III) were exposed to 10 mg PQ/100 ML DDW over a three-month period together with a control group (n = 5). Group I animals died with extensive haemorrhagic pneumonitis 38 hours after the last challenge. Most animals in Group II surviving more than three exposures had a significant reduction (P less than 0.001) in arterial oxygen tension (PaO2) and an increase (P less than 0.001) in the alveolar-arterial O2 gradient. Specific compliance decreased (P less than 0.005) and functional residual capacity and breathing frequency increased (P less than 0.05). Tissue PQ values showed even pulmonary distribution, with evidence of PQ accumulation after repeated inhalation. The lungs showed focal interstitial fibrosis, interstitial thickening, proliferation of macrophages in the alveoli, epithelioid changes in the interstitium, Type II cell hyperplasia, and foci of acute inflammation with consolidation. Controls and Group III animals were normal. This indicates that repeated inhalation of paraquat aerosol induces dose-related interstitial pneumonitis and fibrosis in rabbits.
 ...
PMID:Paraquat lung injury in rabbits. 69 41

Twenty children with ALL that died in 1959-1960 and 59 children with ALL that died in 1969-1970 were analyzed according to the infections at both their terminal illness and their initial presentations. Despite the availability of more effective agents for pseudomonas and staphylococcus, the pattern of infecting organisms at the terminal illness did not change appreciably in this decade. E. coli, pseudomonas, staphylococcus, and candida were the principal organisms involved as a cause of death. Thirty-five of these 79 patients were febrile when they initially presented, prior to the institution of chemotherapy. Seven of the 35 patients (20%) had proved infections. It appears that the fever in the majority of patients at their initial presentations was noninfectious in origin. In 1969-1970, 13 pulmonary aspirates were performed to aid in the etiological diagnosis of diffuse interstitial pneumonia. Only a single case (8%) of pneumonia due to pneumocystis carinii was detected, and it is our suspicion that the majority of these interstitial pneumonias were viral in origin.
 ...
PMID:Infections in children with acute leukemia. 77 73

Chronic pulmonary histoplasmosis is best regarded as an opportunist or saprophytic infection of abnormal pulmonary spaces by a fungus of very low human pathogenicity. Tissue disease results from host immune response to dispersions of soluble antigen from these focal sources. There are two distinct types of clinical and radiological response. One is an acute or subacute illness manifested by often large segmental pneumonic lesions which tend to heal and are designated as early lesions. The other, usually developing as a complication of the first, is a chronic disease marked by persistent cavitation, low gard chronic illness, and a tendency to promote pulmonary fibrosis and often progressive pulmonary insufficiency. The early lesion is a segmental interstitial pneumonitis with central areas of infarct-like necrosis often adjacent to bullous disease and often outlining prominent emphysematous spaces which appear as radiolucencies. These radiological findings are further characterized by early clearing of the interstitial components, infarct-like contraction of the necrotic zones, obliteration of much of the contained emphysematous and bullous spaces, and healing attended by considerable loss of lung volume. Symptoms are variable but tend to be mild. Malaise, fatigability, low-grade fever, aching chest pain and mild cough lasting a few days to a few weeks are usual. Symptoms are ameliorated by rest. Rest and diminished activity are recommended as treatment. Under these circumstances, 80% of early lesions heal completely and probably most of these would heal spontaneously. Any subsequent course of the disease depends on whether or nor large air spaces, adjacent to or contained within the area of pneumonitis, become infected and persist as cavities. This occurs in 20% of early lesions. Once established, an infected cavity tends to persist and to be attended by symptoms of chronic bronchitis with chronic cough and sputum, fatigability, anorexia, and weight loss. Persisting thickwalled cavities often induce gradual development of pulmonary fibrosis, particulary in the lung bases, apparently from aspiration of antigenic material. This and the accelerated obstructive bronchopulmonary disease often lead to progressive pulmonary insufficiency. The use of amphotericin B is recommended for all persistent thick-walled cavities and in some circumstances surgical resection may be indicated.
 ...
PMID:Chronic pulmonary histoplasmosis. 79 26

Interstitial pneumonia due to Pneumocystis carinii was diagnosed in 2 splenectomized owl monkeys. Pneumonia was considered an important lesion in 1 monkey, but only an incidental finding in the 2nd monkey. Nephritis was considered to be the primary lesion in both monkeys.
 ...
PMID:Pneumocystis carinii infection in splenectomized owl monkeys. 80 95

Experimentally induced and naturally acquired lungworm infections (Didelphostrongylus and Capillaria) were studied in opossums, Didelphis marsupialis. Each of 4 helminth-free opossums were experimentally infected with 250 3rd-stage Didelphostrongylus hayesi larvae. At 2 and 8.5 months after infection, 2 animals were necropsied. Hypertrophy of pulmonary smooth muscle characterized D hayesi infections, with lesions pronounced in the vicinity of helminths. There was mucous bronchitis characterized by peribronchial gland hyperplasia, lymphoid nodule formation, and exudation of mucus and eosinophils into bronchioles. Lung from 4 opossums harboring natural infections of D hayesi or Capillaria or both was examined. Concomitant infections produced multifocal, indurated lesions often resulting in generalized consolidation. Microscopic examination revealed pulmonic damage consisting of hypertrophy of smooth muscle, extensive peribronchiolar adenomatoid hyperplasia of alveolar epithelium, and diffuse areas of granulomatous interstitial pneumonia. Capillaria provoked well-defined granulomas, and frequently only eggs and cuticular debris were contained within the lesions. Loss of pouch young by 1 naturally infected feamle was associated with extensive verminous pneumonia.
 ...
PMID:Pathologic manifestations of experimentally and naturally acquired lungworm infections in opossums. 85 Dec 87

Pulmonary disorders occur in 25 to 47 per cent of the patients with Sjogren's Syndrome. These are of two types: 1. related to the major connective tissue disorders which commonly accompany this syndrome, and 2. secondary to the peculiar underlying pathology of Sjogren's Syndrome i.e. sicca disorders of the lung. The latter is the more frequent type, occurring mainly in patients with protected sicca complex unaccompanied by a systemic connective tissue disorder, and consists of chronic bronchitis, subsegmental atelectasis, pneumonia, bronchiectasis, lymphoproliferative pulmonary infiltrates and chronic interstitial pneumonitis which may lead to pulmonary fibrosis. 21 cases of Sjogren's Syndrome, 9 of whom had evidence of pulmonary abnormality, are presented, including a case of interstitial pneumonitis leading to diffuse interstitial pulmonary fibrosis. A review of the literature is included.
 ...
PMID:Pulmonary disorders associated with Sjogren's syndrome. 86 98


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>