Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The chlamydiae are a genetically diverse group of bacteria with a unique intracellular development cycle. The spectrum of clinical manifestations of Chlamydia trachomatis infections in the female includes cervicitis, acute urethral syndrome, pelvic inflammatory disease, salpingitis and the risk of exposure of infants born through an infected birth canal who may develop inclusion conjunctivitis and/or pneumonia. In order to determine the prevalence of cervicovaginal infections caused by C. trachomatis in female population in Cuernavaca, Morelos, we studied 2,407 sexually active women from a suburban area. Genital specimens were collected from each woman and cultured in McCoy cell monolayers. Detection of the bacteria was done by staining with fluorescein-conjugated monoclonal antibodies (Syva Microtrak, Palo Alto CA). 97 of them were culture-positive for C. trachomatis, with and overall prevalence of 4.02 per cent. The most important clinical symptom observed in 47 of the infected patients was an increased or altered vaginal discharge.
 ...
PMID:[Prevalence of cervicovaginal infections caused by Chlamydia trachomatis among female population of the city of Cuernavaca, Morelos]. 161 48

Chlamydia trachomatis, considered the most common sexually transmitted organism, is responsible for a variety of infections in women, including urethral syndrome, cervicitis, endometritis, and salpingitis. It may colonize the lower genital tract and result in asymptomatic infection, ultimately resulting in sterility. An estimated 20-40% of sexually active women have been exposed to Chlamydia, and 4-5% of sexually active US women are estimated to carry Chlamydia in the cervix. Infection may involve the lower genital tract (bartholinitis, cervicitis, acute urethral syndrome), the upper genital tract (endometritis, salpingitis, Fitz-Hugh-Curtis syndrome), or both. However, the principal focus of infection appears to be the cervix. The maternal carriage rate of C. trachomatis ranges between 2-30%. Infection of the female genital tract during pregnancy may result in spontaneous abortion, premature labor, postpartum endometritis, neonatal conjunctivitis, or pneumonia. All women suspected of being colonized by or exposed to C. trachomatis should be evaluated throughly, and treatment should be administered to both the patient and her sexual partner. Since patients with 1 sexually transmitted disease are likely to have another, these women should be screened for Trichomonas, gonorrhea, syphilis, and herpes as well. The recommended treatment for nonpregnant women with C. trachomatis is 500 mg tetracycline 4 times/day, 50 mg minocycline 2 times/day, or 100 mg doxycycline 2 times/day.
 ...
PMID:Chlamydia trachomatis infection in women. 402 Jul 84

Although Chlamydia trachomatis causes important diseases in both men and women, this review focuses on the genital tract disease associated with chlamydial infection in women and on neonatal chlamydial infection. 8 of the 15 serotypes of C. trachomatis are sexually transmitted agents. The unique growth cycle which distinguishes the chlamydiae from all other organisms is described and they are compared to bacteria and viruses. The prevalence and risk factors for chlamydial infections are then discussed. The symptoms, complications, prevalence, diagnosis, and treatment of male genital tract infections are outlined. Experimental and clinical evidence of the role of chlamydiae in lower genital tract diseases of women including Bartholinitis, cervicitis, endometritis, and acute urethral syndrome; in acute salpingitis; and in the Fitz-Hugh-Curtis syndrome is presented and discussed, followed by a discussion of the incidence and prevalence, diagnosis, prognosis, and treatment of neonatal inclusion conjunctivitis and pneumonia due to C. trachomatis. Some possible control measures for neonatal chlamydial infections are recommended and the relative costs and benefits for populations with different incidences are evaluated. Other possible neonatal clinical manifestations and a possible role in preterm labor and delivery, low birth weight, and perinatal mortality are noted. The diagnosis of chlamydial infections by cytology, serology, and culture are discussed, and recommended therapy is outlined.
 ...
PMID:Chlamydial infections in obstetrics and gynecology. 634 Aug 91