Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two common porpoises (Phocoena phocoena), one found stranded on the Isle of Sheppey, Kent, and the other in the Moray Firth, Scotland, in late 1990, were examined post mortem. Lesions of diffuse bronchointerstitial pneumonia were present in both animals; they were characterised by the infiltration of alveoli with leucocytes, macrophages and multinucleate syncytia, the necrosis of bronchial and bronchiolar epithelium, focal proliferation of type II pneumocytes and occasional acidophilic cytoplasmic inclusions in alveolar macrophages and syncytia. Lymphoid depletion was apparent in the spleen, thymus and lymph nodes of both porpoises. Other changes in the Isle of Sheppey porpoise included severe dacryoadenitis. Marked pharyngitis, oesophagitis and balanoposthitis were present in the Moray Firth porpoise. Immunoperoxidase staining revealed the presence of morbillivirus antigen in a range of epithelia from both porpoises. This is the first report of morbillivirus infection in cetaceans from the coast of Great Britain.
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PMID:Morbillivirus infection in two common porpoises (Phocoena phocoena) from the coasts of England and Scotland. 144 Nov 26

Three patients developed dacryoadenitis (DA) or lymphocytic pneumonitis before the diagnosis of lymphocytic hypophysitis (LyH). There were two previous reports of concurrence of DA and LyH. Our patients add support to the idea that DA and LyH are manifestations of a systemic autoimmune disease. We suggest that the discovery of DA should prompt imaging and endocrine investigation of LyH.
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PMID:Bilateral dacryoadenitis complicated by lymphocytic hypophysitis. 1972 44

IgG4-related systemic disease is a recently described entity that can elude even the most astute diagnostician. Patients with the disease, characterized by the infiltration of polyclonal IgG4-positive plasmacytes, can present with single or multi-organ involvement. Manifestations include dacryoadenitis, sialadenitis, thyroiditis, pneumonitis, retroperitoneal fibrosis, pancreatitis, sclerosing cholangitis, tubulointerstitial nephritis, prostatitis, and hypophysitis. We describe a biopsy-confirmed case with extensive multi-organ involvement, including hypophysitis, dacryoadenitis, retroperitoneal fibrosis and tubulointerstitial nephritis. By reporting this case, we hope to bring IgG4-related systemic disease to the attention of the broader medical community as it is an elusive disease that commonly responds to systemic corticosteroids.
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PMID:IgG4-related systemic disease in a Native American man. 2149 45

We report a case of a woman with lymphoproliferative multiorganic immunoglobulin G4 (IgG4) related disease with extensive involvement showing dacryoadenitis, sialoadenitis, parotiditis, pancreatitis, pneumonitis, lymphadenopathy and immune thrombocytopenic purpura. Serum elevation of acute phase reactant, polyclonal hypergammaglobulinemia, positivity for antinuclear antibodies and rheumatoid factor was found. Hystologically plasma cell infiltration was demonstrated on glandular and lymphatic tissue and immunochemistry was positive for IgG4 in > 30%. Immunosuppressive treatment with steroids and azathioprine was given with an excellent clinical response, the marked radiologic evidence of improvement and the decrease in inflammatory makers that conducted to symptom remission are shown in the text.
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PMID:[Immunoglobulin G4-associated to multiorganic lymphoproliferative disease]. 2211 88

This research evaluated the anatomic pathology of rats fed diets containing ground beef which had been treated with aqueous chlorine. The anatomic pathology of 240 rats fed 92 d with diets containing ground beef treated with 0, 50, 200 or 600 ppm chlorine was carried out according to National Institutes of Health bioassay pathology procedures. The major rat tissues were evaluated and the incidence of histopathological conditions was recorded. The inclusion of chlorine-treated meat in the diet was not associated with any increase in incidence of neoplastic lesions, inflammatory lesions or degenerative changes. However, all male rats fed the meat diet both with or without chlorine exhibited mild to moderate hepatic fatty metamorphosis. In all likelihood, the fatty livers were due to the high fat content of the diet (about 35%). The adrenal glands of the control and treated males exhibited fatty metamorphosis. This effect is not explained by diet because even the male rats on the commercial rat feed had fatty adrenal glands. Other histopathologic conditions such as focal hepatitis, triaditis, focal myocarditis, focal lymphocytic infiltration, chronic murine pneumonia, chronic tracheitis, focal acute gastritis, dacryoadenitis, cataract, hyperplastic hepatic nodule or ultimobranchial cysts, when found were not associated with any treatment or sex group. The treatment of ground beef with aqueous chlorine before incorporation into a diet fed rats for 92 d exhibited no apparent effect on the anatomic pathology of rats.
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PMID:Subacute Study of Rats Fed Ground Beef Treated with Aqueous Chlorine - Anatomic Pathology. 3096 86